Results 91 to 100 of about 300,913 (307)

The fate of thiopurine metabolites after switching to low‐dose thiopurine with allopurinol or thioguanine in IBD patients: A retrospective analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Shunting (hypermethylating) thiopurine metabolism, characterized by excessive 6‐MMPR production and (sub)therapeutic 6‐TGN levels, poses a significant challenge in the treatment of inflammatory bowel disease (IBD). This study evaluates the metabolic outcomes of switching to low‐dose thiopurine with allopurinol (LDTA) or thioguanine (TG) in IBD ...
Ahmed B. Bayoumy, Hedwig M. A. D'Agnolo, Nanne K. H. de Boer, Chris J. J. Mulder, Luc J. J. Derijks   +4 more
wiley   +1 more source

Optimization of Ultrasonic-assisted Two-aqueous Extraction of Flavonoids from Rosa roxburghii Tratt and Its Inhibitory Effect on Xanthine Oxidase Activity

Shipin gongye ke-ji, 2023
In this study, ultrasound-assisted aqueous two-phase extraction (UA-ATPE) was adopted to extract flavonoids from Rosa roxburghii Tratt and investigated its inhibitory effect of this flavonoid on xanthine oxidase activity in vitro.
Qianfei ZHUANG, Dandan LIU, Zeyu CHEN, Zufei SHANG, Xiaoyan LIU, Lizhi MA   +5 more
doaj   +1 more source

Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol

Pharmacological Reviews, 2006
The prototypical xanthine oxidase (XO) inhibitor allopurinol, has been the cornerstone of the clinical management of gout and conditions associated with hyperuricemia for several decades.
P. Pacher, A. Nivorozhkin, C. Szabó
semanticscholar   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, EarlyView.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell [PDF]

, 1990
The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the ...
Abouna, Adkison, Eiseman, Granger, Green, Hanks, Hoffee, James T. Snyder, Kamada, Kamiike, Kamiike, Kizaki, Lanir, Lee, Lee, LeMasters, LeMasters, Leonard Makowka, Marotto, Marubayashi, Marubayashi, McCord, Nishida, Parks, Prakash N. Rao, Randy S. Rubin, Rubio, Teperman, Thomas E. Starzl, Thomas R. Walsh, Thomas Weber, Turner, Van Thiel   +32 more
core   +1 more source

Study the effect of kidney stones on serum xanthine oxidase, ecto-5ʹ-nucleotidase activity and E3 SUMO-protein ligase NSE2 (NSMCE2) in Malaysian individuals

Asian Pacific Journal of Tropical Biomedicine, 2015
Objective: To verify possible relations between 5ʹ-nucleotidase, xanthine oxidase to E3 small ubiquitin-like modifier-protein ligase non structural maintenance of chromosomes elements 2 in sera patients with kidney stones and to evaluate the possibility ...
Faridah Yusof, Atheer Awad Mehde, Wesen Adel Mehdi, Hamid Ghazali, Azlina Abd Rahman   +4 more
doaj   +1 more source

Identification of a new mutation in the human xanthine dehydrogenase responsible for xanthinuria type I

Advances in Laboratory Medicine, 2021
Hereditary xanthinuria is a rare, autosomal and recessive disorder characterized by severe hypouricemia and increased xanthine excretion, caused by a deficiency of xanthine dehydrogenase/oxidase (XDH/XO, EC: 1.17.1.4/1.17.3.2) in type I, or by a ...
Collazo Abal Cristina, Romero Santos Susana, González Mao Carmen, Pazos Lago Emilio C., Barros Angueira Francisco, Castiñeiras Ramos Daisy   +5 more
doaj   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Literature-based discovery of diabetes- and ROS-related targets [PDF]

, 2010
Background Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS.
A Erol, A Fontayne, A Iaccio, Adam D Schuyler, AG Reaume, AM Vincent, AM Vincent, AM Vincent, AM Vincent, American-Diabetes-Association, BJ Turner, C Figueroa-Romero, C Plake, D Rebholz-Schuhmann, David J States, E Schwedhelm, EH Sarsour, EL Feldman, EM Olofsson, Eva L Feldman, F Folli, FA Hakim, FR DeRubertis, H Ilieva, H V Jagadish, HB Lee, I Vastrik, J Hur, JL Edwards, JM Jimenez-Andrade, JS Pan, Junguk Hur, JW Russell, KA Sullivan, Kelli A Sullivan, KK Ohlemiller, L Hirschman, M Ashburner, M Brownlee, M Fukuda, M Fukuda, M Kanehisa, M Kawase, Manjusha Pande, N Kameyama, PJ Shaw, RA Fisher, S Cetinkalp, S Ghosh, T Matsunami, VI Perez, Y Aliciguzel, Y Benjamini, Yu Hong, Z Bagi   +54 more
core   +5 more sources

In Vitro α-Amylase, α-Glucosidase, Pancreatic Lipase, Xanthine Oxidase Inhibiting Activity of Agaricus bisporus Extracts

Mycobiology, 2023
In this study, the α-amylase inhibitory activity, α-glucosidase inhibitory activity, pancreatic lipase inhibitory activity, and Xanthine Oxidase inhibitory activity of the fruiting body extracts of 5 varieties of Agaricus bisporus (AB) were confirmed ...
Jung Han Kim, Myoung Jun Jang, Youn Jin Park   +2 more
doaj   +1 more source