Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants
Global Challenges, EarlyView.This review has systematically evaluated the oxidative damage of cornea, tear film, lacrimal gland, conjunctiva and meibomian gland for dry eye, and concluded the antioxidants that are either commercially available or in the research phase. GQDs: Graphene quantum dots; LF: lactoferrin; ROS: Reactive oxygen species; SOD: Superoxide dismutase; tFNA ...
Rong Hu +3 more
wiley +1 more source
Ipomea aquatica EXTRACT INHIBITS LIPOXYGENASE, HYALURONIDASE AND XANTHINE OXIDASE ACTIVITIES
Journal of Academia, 2020 Ipomea aquatica, locally known as water spinach, is one of the most common vegetable consumed by Malaysian. I. aquatica exhibited several biological activities including free radical scavenging, anti-microbial and anti-proliferative.
Muhammad Helmi Nadri
doaj
Antioxidant potential and xanthine oxidase inhibition of flavonol glycosides from Phyllanthus emblica L. leaves [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Hyperuricemia is the cause of gout in the inflammatory joint condition. The xanthine oxidase enzyme is a therapeutic target for gout treatment because it plays a role in the generation of uric acid. Allopurinol is used to treat gout. It prevents
Husnunnisa +3 more
doaj +1 more source
Assessment of Oxidative Stress in Peste Des Petits Ruminants (Ovine Rinderpest) Affected Goats [PDF]
, 2012 The aim of the present investigation was to evaluate oxidative stress in goats affected with peste des petits ruminants (PPR). The experiment was designed to collect blood samples from PPR affected as well as healthy goats during a series of PPR ...
Kataria, A. K. (A), Kataria, N. (N)
core
Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF [PDF]
, 2017 Aims: Elevated serum uric acid concentration (SUA) has been associated with an increased risk of cardiovascular disease, but this may be due to unmeasured confounders.
Chen, Chen-Huan +16 more
core +3 more sources
Antioxidant activity, xanthine oxidase inhibition and acute oral toxicity of Dillenia philippinensis Rolfe (Dilleniaceae) leaf extract. [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2021 Context: Hyperuricemia is a metabolic syndrome characterized by a high serum uric acid level with an increased risk of gout, diabetes, cardiovascular and renal disease.
Sarah S. Ansari +3 more
doaj
Effects of Single-Dose Ultraviolet Radiation on Skin Superoxide Dismutase, Catalase, and Xanthine Oxidase in Hairless Mice [PDF]
, 1990 The effects of a single exposure to UVB radiation on skin antioxidant enzymes and superoxide-generating xanthine oxidase were examined in Skh:HR-1 hairless mice. Significant decreases in superoxide dismutase (SOD) and catalase (CAT) were observed by 12 h
Naylor, Mark F, Pence, Barbara C
core +1 more source
In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors
BMC Chemistry, 2019 Background Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome.
Neelam Malik +2 more
doaj +1 more source
Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout. [PDF]
, 2019 ObjectiveLesinurad (LESU) is a selective urate reabsorption inhibitor approved at 200 mg daily for use with a xanthine oxidase inhibitor (XOI) to treat hyperuricaemia in gout patients failing to achieve target serum urate on XOI. The aim of the study was
Baumgartner, Scott +8 more
core +1 more source
Literature-based discovery of diabetes- and ROS-related targets [PDF]
, 2010 Background Reactive oxygen species (ROS) are known mediators of cellular damage in multiple diseases including diabetic complications. Despite its importance, no comprehensive database is currently available for the genes associated with ROS.
A Erol +54 more
core +5 more sources