Results 91 to 100 of about 689,556 (183)

Crystal Structures of Mammalian Xanthine Oxidoreductase Bound with Various Inhibitors: Allopurinol, Febuxostat, and FYX-051

Journal of Nippon Medical School, 2008
Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR can thus decrease the concentration of uric acid in serum. Crystal structures of XOR bound with various inhibitors reveal that inhibitors can be categorized into three types, i.e.
Okamoto, Ken, Nishino, Takeshi
openaire   +3 more sources

Investigation of aldehyde oxidase and xanthine oxidoreductase in rainbow trout (Oncorhynchus mykiss) [PDF]

Molybdo-flavoenzymes (MFEs), aldehyde oxidase (AOX) and xanthine oxidoreductase (XOR) are involved in the oxidation of N-heterocyclic compounds and aldehydes, many of which are environmental pollutants, drugs and vitamins.
Aburas, Omaro A Emhmed
core   +2 more sources

Localization of xanthine oxidoreductase activity using the tissue protectant polyvinyl alcohol and final electron acceptor Tetranitro BT.

, 1991
We have detected xanthine oxidoreductase activity in unfixed cryostat sections of rat and chicken liver, rat duodenum, and bovine mammary gland using the tissue protectant polyvinyl alcohol, the electron carrier 1-methoxyphenazine methosulfate, the ...
R Gossrau, W M Frederiks, A Kooij, C J Van Noorden   +3 more
core   +1 more source

ANTHOCYANIDINES AS INHIBITORS OF XANTHINE-OXIDASE

, 1995
Anthocyanidines as inhibitors of xanthine ...
RASTELLI, Giulio, A. ALBASINI, COSTANTINO, Luca   +2 more
core  

Research Article Xanthine Oxidoreductase Reference Values in Platelet-Poor Plasma and Platelets in Healthy Volunteers [PDF]

, 2016
Copyright © 2015 Elżbieta Cecerska-Heryc ́ et al.This is an open access article distributed under theCreative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalwork is properly ...
Urbanska Marta, Elhbieta Cecerska-heryt, Anna Jesionowska, Pawlak Dominika, Szupiluk Klaudyna, Mdczka Dominika, Barbara Dobwgowska, Siewierska Katarzyna   +7 more
core  

Computational Investigation of the Inhibition Mechanism of Xanthine Oxidase by Oxadiazole Derivatives

Xanthine oxidoreductase (XOR) is a key enzyme in uric acid production and an important therapeutic target for the treatment of hyperuricemia and gout. Among clinically available XOR inhibitors, Topiroxostat (FYX-051) is unique because it combines both ...
Mozhdeh Ghafari, G. Andrés Cisneros, Chao Dong   +2 more
core   +2 more sources

Tissue- and cell-specific expression of mouse xanthine oxidoreductase gene in vivo: regulation by bacterial lipopolysaccharide

, 1995
The expression of the xanthine oxidoreductase gene was studied in various mouse organs and tissues, under basal conditions and on treatment with bacterial lipopolysaccharide.
M. Li Calzi, M. Terao, M. Kurosaki, E. Garattini, E. Scanziani   +4 more
core   +1 more source

Differences in Activities of Antioxidant Superoxide Dismutase, Glutathione Peroxidase and Prooxidant Xanthine Oxidoreductase/Xanthine Oxidase in the Normal Corneal Epithelium of Various Mammals [PDF]

, 2007
Summary Under normal conditions, antioxidants at the corneal surface are balanced with the production of reactive oxygen species without any toxic effects.
J Pláteník, Č Čejka, M Vejražka, A Midelfart, S Štípek, J Kovačeva, T Ardan, J Čejková   +7 more
core  

Inhibition mechanism of xanthine oxidoreductase inhibitors and their effect on purine metabolism

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022
openaire   +1 more source

Cardiovascular Events During Treatment With Xanthine Oxidoreductase Inhibitors in Patients With Gout and Hyperuricemia in Japan　- A JMDC Claims Database Study. [PDF]

Circ Rep
Kario K, Akari S, Kanegae H.
europepmc   +1 more source