Results 71 to 80 of about 689,556 (183)

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Synergistic Enhancement of Antioxidant Activity in Arbutus unedo Leaf Extract by Biological Fluids: Implications for Functional and Nutraceutical Applications

Biotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2189-2201, October 2026.
ABSTRACT This study examined the effect of biological fluids (saliva, blood plasma, and urine) on the antioxidant capacity of an aqueous extract derived from Arbutus unedo leaves. The extract displayed a concentration‐dependent reducing activity in the ferric reducing power assay (IC50 = 292 ± 7.54 µg/mL) and phosphomolybdenum assays (IC50 = 461.67 ± 4.
Idir Moualek, Hamdi Bendif, Karima Benarab, Giulio Lupidi, Fehmi Boufahja, Stefania Garzoli, Karim Houali   +6 more
wiley   +1 more source

Mutations Associated with Functional Disorder of Xanthine Oxidoreductase and Hereditary Xanthinuria in Humans

, 2012
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and xanthine to uric acid with concomitant reduction of either NAD+ or O2.
Ken Okamoto, Yoshihiro Amaya, Takeshi Nishino, Kimiyoshi Ichida   +3 more
core   +1 more source

The Thermodynamics of Xanthine Oxidoreductase Catalysis [PDF]

, 1999
Xanthine oxidoreductase is a complex enzyme found in a wide range of organisms. Recent interest in this enzyme stems from its ability to produce reactive oxygen species under a range of conditions.
Sanders, Stephen A., Massey, Vincent
core   +1 more source

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Unveiling the anti-gout potential of terpenes isolated from Penicillium sp. supported by in silico studies

Future Journal of Pharmaceutical Sciences
Background Genus Penicillium represents one of the most prolific fungi in terms of biosynthesis of bioactive secondary metabolites. This review aims to survey the reported terpenoids isolated from different species of genus Penicillium and virtually ...
Abdelrhman M. Mohamed, Shaza H. Aly, Ahmed M. Elissawy, Mohamed A. Elanany, Rakesh K. Bachheti, Abdel Nasser B. Singab   +5 more
doaj   +1 more source

Crystal Structures of Urate Bound Form of Xanthine Oxidoreductase: Substrate Orientation and Structure of the Key Reaction Intermediate

, 2016
Two contradictory models have been proposed for the binding mode of the substrate xanthine to and its activation mechanism by xanthine oxidoreductase. In an effort to distinguish between the two models, we determined the crystal structures of the urate ...
Ken Okamoto (778187), Yuko Kawaguchi (2245831), Emil F. Pai (411935), Takeshi Nishino (2122573), Bryan T. Eger (2122570)   +4 more
core   +1 more source

Crystallographic, Kinetic and Computational Studies on the Reaction Mechanism of Xanthine Oxidoreductase [PDF]

, 2011
Xanthine oxidoreductase is a molybdenum-containing enzyme which catalyzes the hydroxylation on sp2 hybridized carbon centers of a broad family of substrates including purines, aldehydes and various other heterocycles.
Cao, Hongnan
core  

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications

, 2004
There is substantial evidence that oxidative stress participates in the pathophysiology of cardiovascular disease. Biochemical, molecular and pharmacological studies further implicate xanthine oxidoreductase (XOR) as a source of reactive oxygen species ...
Berry, Cristine E, Hare, Joshua M
core   +1 more source

Enzyme@Silicone: A Versatile Combo for Robust Synthetic Biocatalysis?

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
Silicone‐based polymers are versatile materials for enzyme immobilization, offering unique advantages such as chemical inertness, thermal stability, and tunable morphology. This review highlights their applications in synthetic biocatalysis, from batch to continuous processes, and addresses key challenges such as mass transport limitations and ...
Marion B. Ansorge‐Schumacher
wiley   +1 more source