Results 11 to 20 of about 689,556 (183)
Pro-Aging Effects of Xanthine Oxidoreductase Products [PDF]
Antioxidants, 2020 The senescence process is the result of a series of factors that start from the genetic constitution interacting with epigenetic modifications induced by endogenous and environmental causes and that lead to a progressive deterioration at the cellular and
Maria Giulia Battelli +3 more
doaj +3 more sources
Inhibition of Xanthine Oxidoreductase Enhances the Potential of Tyrosine Kinase Inhibitors against Chronic Myeloid Leukemia [PDF]
Antioxidants, 2020 Chronic myeloid leukemia (CML) is characterized by the expression of the oncogenic kinase BCR-ABL. Although tyrosine kinase inhibitors (TKIs) against BCR-ABL represent the standard therapeutic option for CML, resistances to TKIs can be a serious problem.
Marta Romo-González +4 more
doaj +4 more sources
BIOCHEMICAL ROLE OF XANTHINE OXIDOREDUCTASE AND ITS NATURAL INHIBITORS: AN OVERVIEW [PDF]
International Journal of Pharmacy and Pharmaceutical Sciences, 2016 Xanthine oxidoreductase (XOR) is a widely distributed housekeeping enzyme in mammals that catalyzes the last two steps in human purine catabolism to produce uric acid.
Mandava, Kiranmai, Batchu, Uma Rajeswari
core +4 more sources
The Role of Oxidative Stress in Hyperuricemia and Xanthine Oxidoreductase (XOR) Inhibitors [PDF]
Oxidative Medicine and Cellular Longevity, 2021 Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA). Alterations in SUA homeostasis have been linked to a number of diseases, and hyperuricemia is the major etiologic factor of gout and has been correlated with metabolic ...
Ning Liu +8 more
openaire +3 more sources
Evaluation of the Effectiveness of Xanthine Oxidoreductase Inhibitors on Haemodialysis Patients using a Marginal Structural Model. [PDF]
Sci Rep, 2017 AbstractA lower serum uric acid (UA) level has been associated with a higher mortality rate in haemodialysis patients. We investigated the long-term confounding factors of UA and mortality, and fitted a marginal structural model (MSM) based on the causal effect of xanthine oxidoreductase inhibitors (XORi).
Ishii T, Taguri M, Tamura K, Oyama K.
europepmc +4 more sources
An Extremely Potent Inhibitor of Xanthine Oxidoreductase [PDF]
Journal of Biological Chemistry, 2003 TEI-6720 (2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid) is an extremely potent inhibitor of xanthine oxidoreductase. Steady state kinetics measurements exhibit mixed type inhibition with K(i) and K(i)' values of 1.2 +/- 0.05 x 10(-10) m and 9 +/- 0.05 x 10(-10) m, respectively.
Ken Okamoto +5 more
openaire +2 more sources
, 2023 Xanthine oxidoreductase (XOR) is an enzyme found in various organisms. It converts hypoxanthine to xanthine and urate, which are crucial steps in purine elimination in humans.
Yazdan Maghsoud (6560168) +2 more
core +5 more sources
Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol [PDF]
, 2023 Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans.
G. Andrés, Cisneros +2 more
core +2 more sources
Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice [PDF]
Nutrition & Diabetes, 2021 AbstractPlasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed standard diets with or without topiroxostat for 4 weeks. Body weight and food intake were constantly
Takashi Nakamura +6 more
openaire +3 more sources
The Journal of Clinical Hypertension, 2021 Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects ...
Kazuomi Kario +15 more
doaj +1 more source