Results 21 to 30 of about 689,556 (183)
Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme
Antioxidants, 2023 Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species.
Rosario Rullo +6 more
doaj +1 more source
Nitro-oleic Acid, a Novel and Irreversible Inhibitor of Xanthine Oxidoreductase [PDF]
Journal of Biological Chemistry, 2008 Xanthine oxidoreductase (XOR) generates proinflammatory oxidants and secondary nitrating species, with inhibition of XOR proving beneficial in a variety of disorders. Electrophilic nitrated fatty acid derivatives, such as nitro-oleic acid (OA-NO2), display anti-inflammatory effects with pleiotropic properties.
Eric E, Kelley +9 more
openaire +2 more sources
Biomedicines, 2021 To unravel associations between plasma xanthine oxidoreductase (XOR) and diabetic vascular complications, especially distal symmetric polyneuropathy (DSP), we investigated plasma XOR activities using a novel assay. Patients with type 2 diabetes mellitus (
Midori Fujishiro +11 more
doaj +1 more source
Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview [PDF]
Medical Science Monitor, 2016 Uric acid is the final oxidation product of purine metabolism in humans. Xanthine oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric acid, accompanying the production of reactive oxygen species (ROS). Uric acid usually forms ions and salts known as urates and acid urates in serum.
Chen, Changyi +2 more
openaire +2 more sources
Inhibition of Nodule Functioning in Cowpea by a Xanthine Oxidoreductase Inhibitor, Allopurinol [PDF]
Plant Physiology, 1988 Allopurinol (1H-pyrazolo-[3,4-d]pyrimidine-4-ol), an inhibitor of xanthine oxidation in ureide-producing nodulated legumes, was taken up from the rooting medium, translocated in xylem, and transferred to nodules of both the ureide-forming cowpea (Vigna unguiculata L. Walp.) and the amide-forming white lupin (Lupinus albus L.).
C A, Atkins +3 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Pathologic calcification of cartilage consists of the formation of basic calcium phosphate (BCP) and/or calcium pyrophosphate dihydrate (CPPD) containing calcium crystals in mature hyaline or articular cartilage and is associated with aging, cartilage ...
Sonia Nasi +9 more
doaj +1 more source
Indian Journal of Rheumatology, 2022 The current study conducted a critical review on available clinical evidence for topiroxostat, indicated for managing hyperuricemia in patients with or without gout.
S Chandrashekara, Binoy J Paul
doaj +1 more source
Xanthine oxidoreductase: A leading actor in cardiovascular disease drama
Redox Biology, 2021 Cardiovascular diseases (CVD) are the leading cause of global mortality and their pathogenesis lies mainly in the atherosclerotic process. There are close connections linking oxidative stress and inflammation to endothelial dysfunction, atherosclerosis ...
Letizia Polito +3 more
doaj +1 more source
Neurol Med Chir (Tokyo), 2015 Global cerebral ischemia and reperfusion (I/R) often result in high mortality. Free radicals play an important role in global cerebral I/R. Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol, have been reported to protect tissues from damage caused by reactive oxygen species (ROS) by inhibiting its production through XOR inhibition.
Suzuki G +5 more
europepmc +4 more sources
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress [PDF]
, 2009 Oxidative stress plays an important role in the progression of vascular endothelial dysfunction. The two major systems generating vascular oxidative stress are the NADPH oxidase and the xanthine oxidase pathways. Allopurinol, a xanthine oxidase inhibitor,
Struthers, Allan D. +2 more
core +1 more source