Results 41 to 50 of about 689,556 (183)

A flow cytometric analysis of the inhibition of platelet reactivity due to nitrite reduction by deoxygenated erythrocytes. [PDF]

PLoS ONE, 2014
Nitric oxide (NO), a small gas molecule, has long been known to be a potent inhibitor of platelet function but the physiological and pathological implications of platelet inhibition by NO have not been well clarified. We recently showed that the addition
Krittapoom Akrawinthawong, Ji Won Park, Barbora Piknova, Nathawut Sibmooh, Suthat Fucharoen, Alan N Schechter   +5 more
doaj   +1 more source

Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase [PDF]

, 2023
Xanthine oxidoreductase is a metalloenzyme that catalyzes the final steps in purine metabolism by converting hypoxanthine to xanthine and then uric acid.
Ken Okamoto, Sekine, Mai, Russ Hille, Takeshi Nishino, Okamoto, Ken, Koji Nagata, Nishino, Takeshi, Ichida, Kimiyoshi, Nagata, Koji, Pai, Emil F, Mai Sekine, Emil F. Pai, Kimiyoshi Ichida, Hille, Russ   +13 more
core   +1 more source

Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis [PDF]

, 2001
Experimental bacterial meningitis due to Streptococcus pneumoniae in infant rats was associated with a time-dependent increase in CSF and cortical urate that was approximately 30-fold elevated at 22 h after infection compared to baseline.
Christen, Stephan, Täuber, Martin G., Leib, Stephen L., Bifrare, Yeong-Delphine, Siegenthaler, Corinne, Christen S, Leib SL, Bifrare YD, Täuber MG, Siegenthaler C   +9 more
core   +1 more source

Xanthine Oxidoreductase Activities

, 2020
Xanthine oxidoreductase (XOR) is the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid. XOR is widely distributed throughout living organisms and is highly conserved in prokaryotic, plant, and animal species.
Letizia Polito, Andrea Bolognesi, Massimo Bortolotti, Maria Giulia Battelli   +3 more
core   +1 more source

Inhibition Mechanisms of Xanthine Oxidoreductase Inhibitors

Nihon Ika Daigaku Igakkai Zasshi, 2007
Xanthine oxidoreductase (XOR) catalyzes the conversion of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR block conversion of the oxypurines (hypoxanthine and xanthine) to uric acid, thus decreasing serum concentration of uric acid.
openaire   +2 more sources

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Xanthine oxidoreductase inhibitor topiroxostat ameliorates podocyte injury by inhibiting the reduction of nephrin and podoplanin

Nefrología, 2021
Topiroxostat, an inhibitor of xanthine oxidoreductase (XOR) was shown to reduce urinary albumin excretion of hyperuricemic patients with chronic kidney disease. However, its pharmacological mechanism is not well understood. In this study, we examined the effects of topiroxostat on glomerular podocytes.
Ying Zhang, Yoshiyasu Fukusumi, Mutsumi Kayaba, Takashi Nakamura, Ryusuke Sakamoto, Naoki Ashizawa, Hiroshi Kawachi   +6 more
openaire   +4 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Xanthine oxidoreductase and xanthine oxidase in human cornea [PDF]

, 2002
Xanthine oxidoreductase (xanthine dehydrogenase + xanthine oxidase) is a complex enzyme that catalyzes the oxidation of hypoxanthine to xanthine, subsequently producing uric acid.
Ardan, T., Midelfart, A., Cejkova, J., Filipec, M.   +3 more
core  

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source