Results 31 to 40 of about 689,556 (183)

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP

Frontiers in Pharmacology, 2019
Germline mutations in cellular-energy associated genes have been shown to lead to various monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain, liver, heart, and kidneys, which are the body’s top energy-consuming ...
Todd A. Johnson, H. A. Jinnah, Naoyuki Kamatani   +2 more
doaj   +1 more source

A Post-NGP Mitsuokella jalaludinii as a Therapeutic Candidate for Gout. [PDF]

Microbiologyopen
Schematic summary of the therapeutic mechanisms and evaluation of the post–NGP strain M. jalaludinii PMC73 for gout. PMC73 demonstrated uric acid–lowering efficacy through purine catabolism and hypoxanthine utilization, along with intracellular uric acid reduction in macrophages.
Hossain MS, Kim S, Aziz MT, Ahmed I, Shuvo MSH, Yang H, Jang Y, Kim M, Jang S, Kim Y, Oh S, Nam Y, Seo H, Song HY.   +13 more
europepmc   +2 more sources

Some opportunities of using xanthine oxidase inhibitors

Современная ревматология, 2019
The review presents modern concepts of the role of xanthine oxidase (XO) in the pathogenesis of a number of diseases. It has been shown that XO activity can be associated with the development and progression not only of gout, but, possibly, diabetes ...
O. V. Zhelyabina, M. S. Eliseev
doaj   +1 more source

U-shaped association of uric acid to overall-cause mortality and its impact on clinical management of hyperuricemia

Redox Biology, 2022
Serum uric acid (SUA) is significantly elevated in obesity, gout, type 2 diabetes mellitus, and the metabolic syndrome and appears to contribute to the renal, cardiovascular and pulmonary comorbidities that are associated with these disorders.
William T. Crawley, Cyprien G. Jungels, Kurt R. Stenmark, Mehdi A. Fini   +3 more
doaj   +1 more source

Neuroprotective Effects of <i>Carica papaya</i> in Experimental Models of Neurodegeneration: A Comprehensive Review. [PDF]

Food Sci Nutr
Carica papaya preparations have produced changes in antioxidant, Nrf2‐related, cholinergic, amyloid‐associated, inflammatory, apoptotic, neuronal, and behavioral endpoints in preclinical models. The evidence is model‐ and preparation‐specific, and clinical efficacy has not been established. ABSTRACT Carica papaya (C.
Hossan R, Selim S, Rakib IH, Sayeed MA, Chakrabarty A, Hossain MA, Mia E, Debnath D, Bristy AH, Al Hasan MS.   +9 more
europepmc   +2 more sources

New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds

Frontiers in Pharmacology, 2022
Hyperuricemia is the result of increased production and/or underexcretion of uric acid. Hyperuricemia has been epidemiologically associated with multiple comorbidities, including metabolic syndrome, gout with long-term systemic inflammation, chronic ...
Bendong Yang, Meiling Xin, Shufei Liang, Xiaoxue Xu, Tianqi Cai, Ling Dong, Chao Wang, Meng Wang, Yuting Cui, Xinhua Song, Xinhua Song, Jinyue Sun, Wenlong Sun, Wenlong Sun   +13 more
doaj   +1 more source

The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]

, 2009
Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
Allan Struthers, Jacob George, George, Jacob, Struthers, Allan   +3 more
core   +1 more source

Xanthine oxidoreductase inhibition – A review of computational aspect

, 2020
Xanthine Oxidoreductase (XOR) exists in a variety of organisms from bacteria to humans and catalyzes the oxidation of hypoxanthine to xanthine and from xanthine to uric acid. Excessive uric acid could lead to gout and hyperuricemia.
Montes, Milka O., Dong, Chao, Al-Sawai, Wael M.   +2 more
core   +1 more source

Effect of uric acid-lowering therapy on renal function in patients with chronic kidney disease: a systematic review and meta-analysis

Renal Replacement Therapy, 2021
Background Whether uric acid (UA)-lowering therapy (ULT) is effective in reducing the progression of renal dysfunction in patients with chronic kidney disease (CKD) remains controversial.
Yukio Maruyama, Takanori Kumagai, Naoki Sugano, Shigetaka Yoshida, Kimiyoshi Ichida, Shunya Uchida   +5 more
doaj   +1 more source

Raising Awareness Towards Underdiagnosed Renal Hypouricemia: A Case Report

Revista Portuguesa de Nefrologia e Hipertensão, 2023
Renal hypouricemia (RHUC) is an autosomal recessive disease caused by the dysfunction of uric acid (UA) transporters in the proximal tubule causing increased fractional excretion of uric acid (FEUA).
Pedro Lisboa-Gonçalves, Filipa Ferreira, Isabel Tavares, João Paulo Oliveira   +3 more
doaj   +1 more source