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Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure [PDF]
Scientific Reports, 2023 Xanthines such as caffeine and theobromine are among the most consumed psychoactive stimulants in the world, either as natural components of coffee, tea and chocolate, or as added ingredients.
Hong Mao +12 more
exaly +7 more sources
Experimental and Theoretical Studies on Acid Corrosion Inhibition of API 5L X70 Steel with Novel 1-N-α-d-Glucopyranosyl-1H-1,2,3-Triazole Xanthines [PDF]
Molecules, 2023 A series of novel 1-N-α-d-glucopyranosyl-1H-1,2,3-triazole xanthines was synthesized from azido sugars (glucose, galactose, and lactose) and propargyl xanthines (theophylline and theobromine) using a typical copper (I)-catalyzed azide–alkyne 1,3-dipolar ...
Alma Sánchez-Eleuterio +9 more
doaj +3 more sources
Chemistry Central Journal, 2017 Background Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum activities including anticancer ...
Samar El-kalyoubi +2 more
exaly +4 more sources
Efficacy and safety profile of xanthines in COPD: a network meta-analysis
European Respiratory Review, 2018 Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and
Victor K Kornev +2 more
exaly +4 more sources
The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines. [PDF]
ACS Pharmacol Transl Sci, 2021 The orphan nuclear receptor tailless homologue (TLX) is expressed almost exclusively in neural stem cells acting as an essential factor for their survival and is hence considered as a promising drug target in neurodegeneration.
Faudone G +10 more
europepmc +2 more sources
Xanthines Studied via Femtosecond Fluorescence Spectroscopy
Molecules, 2016 Xanthines represent a wide class of compounds closely related to the DNA bases adenine and guanine. Ubiquitous in the human body, they are capable of replacing natural bases in double helices and give rise to four-stranded structures. Although the use of
Pascale Changenet-Barret +3 more
doaj +2 more sources
Recent Advances in the Synthesis of Xanthines: A Short Review [PDF]
Scientifica, 2022 Xanthine and its derivatives are considered a pharmacologically potential moiety that manifests immense biological activities. Owing to this much diversity in the biological field, this scaffold has fascinated the attention of many researchers around the
Anandi Kapri, Nitin Gupta, Sumitra Nain
doaj +2 more sources
Frontiers in Chemistry, 2019 Substituted xanthine derivatives are important bioactive molecules. Herein we report on a new, practical synthesis of 6-amino-5-carboxamidouracils, the main building blocks for the preparation of 8-substituted xanthines, by condensation of 5,6 ...
Daniel Marx +4 more
doaj +2 more sources
Green Processing and Synthesis, 2021 A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.
Ramadan Ahmed Mekheimer +2 more
exaly +2 more sources
Journal of Analytical Methods in Chemistry, 2013 Raw material, different formulations of foods, and dietary supplements of mate demands control of the content of bioactive substances for which high performance thin layer chromatography (TLC), described here, presents simple and rapid approach for ...
Mirza Bojić +3 more
doaj +2 more sources