Results 11 to 20 of about 6,368 (267)

Facile N9-Alkylation of Xanthine Derivatives and Their Use as Precursors for N-Heterocyclic Carbene Complexes

Molecules, 2021
The xanthine-derivatives 1,3,7-trimethylxanthine, 1,3-dimethyl-7-benzylxanthine and 1,3-dimethyl-7-(4-chlorobenzyl)xanthine are readily ethylated at N9 using the cheap alkylating agents ethyl tosylate or diethyl sulfate. The resulting xanthinium tosylate
Moloud Mokfi, Jörg Rust, Christian W. Lehmann, Fabian Mohr   +3 more
doaj   +1 more source

Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]

AGE, 1997
Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung, B S, Baek, S H, Song, M S, Kim, J I, Huh, K H, Shim, K W, Kim, K H, Lee   +7 more
openaire   +2 more sources

Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety with in vitro neuroprotective and MAO-B inhibitory activities

Biotechnology & Biotechnological Equipment, 2022
This study is focused on determination of the most appropriate synthetic approach for obtaining series of theophylline-7-acetyl semi- and thiosemicarbazide hybrids by using the molecular hybridization strategy with and without a catalyst.
Javor Mitkov, Magdalena Kondeva-Burdina, Lily Peikova, Maya Georgieva, Alexander Zlatkov   +4 more
doaj   +1 more source

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Green Processing and Synthesis, 2021
A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.
Mekheimer Ramadan Ahmed, Hayallah Alaa M., Moustafa Moustafa Sherief, Al-Mousawi Saleh Mohammed, Abd-Elmonem Mohamed, Mostafa Sara M., Abo Elsoud Fatma A., Sadek Kamal Usef   +7 more
doaj   +1 more source

Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary ...
K. V. Aleksandrova, Ye. S. Pruhlo, Ye. K. Mykhalchenko, O. S. Shkoda, O. Yu. Cherchesova   +4 more
doaj   +1 more source

Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

Zaporožskij Medicinskij Žurnal, 2021
Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai, M. I. Romanenko, D. H. Ivanchenko   +2 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source

Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]

, 2012
Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose, George G. Dougherty, Jeffrey K. Yao, Joseph McEvoy, Kenji Hashimoto, Matcheri S. Keshavan, Ravinder D. Reddy, Rima Kaddurah-Daouk, Ruth Condray, Wayne R. Matson   +9 more
core   +10 more sources

Towards Splicing Therapy for Lysosomal Storage Disorders: Methylxanthines and Luteolin Ameliorate Splicing Defects in Aspartylglucosaminuria and Classic Late Infantile Neuronal Ceroid Lipofuscinosis

Cells, 2021
Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
doaj   +1 more source

Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca 2+ release [PDF]

, 2015
Objective Caffeine reduces toxic Ca2+ signals in pancreatic acinar cells via inhibition of inositol 1,4,5-trisphosphate receptor (IP3R)-mediated signalling, but effects of other xanthines have not been evaluated, nor effects of xanthines on experimental ...
Booth, David M, Cane, Matthew C, Chvanov, Michael, Criddle, David N, Elliott, Victoria, Haynes, Andrea C, Huang, Wei, Latawiec, Diane, Mukherjee, Rajarshi, Ouyang, Yulin, Petersen, Ole H, Sutton, Robert, Szatmary, Peter, Tepikin, Alexei V, Wen, Li, Zhang, Xiaoying   +15 more
core   +2 more sources