Results 21 to 30 of about 16,457 (321)

Assessment of pediatric asthma drug use in three European countries; a TEDDY study. [PDF]

, 2010
Asthma drugs are amongst the most frequently used drugs in childhood, but international comparisons on type and indication of use are lacking. The aim of this study was to describe asthma drug use in children with and without asthma in the Netherlands ...
A Clavenna, A Clavenna, A Clavenna, A Neubert, Adriana Ceci, AE Vlug, AG Kaditis, Alfredo Nicolosi, Antje Neubert, Carlo Giaquinto, DC Goodman, DR Taylor, Elif Fatma Sen, Eugenio Baraldi, G Menniti-Ippolito, Geert W. ‘t Jong, Gino Picelli, H Bisgaard, H Bisgaard, H Bisgaard, HT Sorensen, HWM Lamberts, I Wong, Ian C. Wong, J Lei van der, J Panickar, JJ Korelitz, JM Joesch, K Furu, Katia M. C. Verhamme, LA Khaled, LB Bacharier, LY Wang, M Bianchi, Macey Murray, Mariagrazia Felisi, MC Sturkenboom, ME Bollinger, MG Zuidgeest, Miriam C. J. M. Sturkenboom, PL Brand, R Buhl, S Sekhsaria, SF Lanes, SJ Szefler, SR Salpeter, T Gislason, TW Vries de, Yingfen Hsia   +48 more
core   +10 more sources

Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary ...
K. V. Aleksandrova, Ye. S. Pruhlo, Ye. K. Mykhalchenko, O. S. Shkoda, O. Yu. Cherchesova   +4 more
doaj   +1 more source

Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]

AGE, 1997
Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung, B S, Baek, S H, Song, M S, Kim, J I, Huh, K H, Shim, K W, Kim, K H, Lee   +7 more
openaire   +2 more sources

Towards Splicing Therapy for Lysosomal Storage Disorders: Methylxanthines and Luteolin Ameliorate Splicing Defects in Aspartylglucosaminuria and Classic Late Infantile Neuronal Ceroid Lipofuscinosis

Cells, 2021
Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
doaj   +1 more source

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Green Processing and Synthesis, 2021
A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.
Mekheimer Ramadan Ahmed, Hayallah Alaa M., Moustafa Moustafa Sherief, Al-Mousawi Saleh Mohammed, Abd-Elmonem Mohamed, Mostafa Sara M., Abo Elsoud Fatma A., Sadek Kamal Usef   +7 more
doaj   +1 more source

Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

Zaporožskij Medicinskij Žurnal, 2021
Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai, M. I. Romanenko, D. H. Ivanchenko   +2 more
doaj   +1 more source

Q-Tube®-Assisted Alkylation and Arylation of Xanthines and Other N-H-Containing Heterocycles in Water

Chemistry, 2021
In this paper, a simple and clean process for the alkylation and arylation of nitrogen-containing heterocycles is reported. The reactions were conducted using the Q-tube® as a non-conventional technology, in water as a green solvent, at overboiling ...
Cecilia Scimmi, Margherita Cardinali, Laura Abenante, Marina Amatista, Francesca Giulia Nacca, Eder J. Lenardao, Luca Sancineto, Claudio Santi   +7 more
doaj   +1 more source

Associations between purine metabolites and clinical symptoms in schizophrenia [PDF]

, 2012
Background: The antioxidant defense system, which is known to be dysregulated in schizophrenia, is closely linked to the dynamics of purine pathway. Thus, alterations in the homeostatic balance in the purine pathway may be involved in the pathophysiology
Debra M. Montrose, George G. Dougherty, Jeffrey K. Yao, Joseph McEvoy, Kenji Hashimoto, Matcheri S. Keshavan, Ravinder D. Reddy, Rima Kaddurah-Daouk, Ruth Condray, Wayne R. Matson   +9 more
core   +10 more sources

Effects of early aminophylline therapy on clinical outcomes in premature infants

Pediatrics and Neonatology, 2023
Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in ...
Yi-Ting Chu, Jin-Shuen Chen, Yao-Shen Chen, Chih-Chieh Yang, Chun-Hao Yin, Hsiao-Ping Wang, Yee-Hsuan Chiou   +6 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source