Results 21 to 30 of about 42,906 (302)

Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines

British Journal of Pharmacology, 2020
A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived autocrine/paracrine mediator that acts pharmacologically at four different ...
K. Jacobson, Zhang-Guo Gao, P. Matricon, M. Eddy, Jens Carlsson   +4 more
semanticscholar   +1 more source

Effects of early aminophylline therapy on clinical outcomes in premature infants

Pediatrics and Neonatology, 2023
Background: Aminophylline use and the association between clinical outcomes and therapy timing have been less investigated. The objective of this study was to determine the efficacy of early aminophylline use (within the first two days of life) in ...
Yi-Ting Chu, Jin-Shuen Chen, Yao-Shen Chen, Chih-Chieh Yang, Chun-Hao Yin, Hsiao-Ping Wang, Yee-Hsuan Chiou   +6 more
doaj   +1 more source

Facile N9-Alkylation of Xanthine Derivatives and Their Use as Precursors for N-Heterocyclic Carbene Complexes

Molecules, 2021
The xanthine-derivatives 1,3,7-trimethylxanthine, 1,3-dimethyl-7-benzylxanthine and 1,3-dimethyl-7-(4-chlorobenzyl)xanthine are readily ethylated at N9 using the cheap alkylating agents ethyl tosylate or diethyl sulfate. The resulting xanthinium tosylate
Moloud Mokfi, Jörg Rust, Christian W. Lehmann, Fabian Mohr   +3 more
doaj   +1 more source

Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]

AGE, 1997
Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
H Y, Chung, B S, Baek, S H, Song, M S, Kim, J I, Huh, K H, Shim, K W, Kim, K H, Lee   +7 more
openaire   +2 more sources

Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety with in vitro neuroprotective and MAO-B inhibitory activities

Biotechnology & Biotechnological Equipment, 2022
This study is focused on determination of the most appropriate synthetic approach for obtaining series of theophylline-7-acetyl semi- and thiosemicarbazide hybrids by using the molecular hybridization strategy with and without a catalyst.
Javor Mitkov, Magdalena Kondeva-Burdina, Lily Peikova, Maya Georgieva, Alexander Zlatkov   +4 more
doaj   +1 more source

Microwave-assisted reactions: Efficient and versatile one-step synthesis of 8-substituted xanthines and substituted pyrimidopteridine-2,4,6,8-tetraones under controlled microwave heating

Green Processing and Synthesis, 2021
A green, simple one-pot microwave-assisted synthesis of xanthines and pyrimidopetridines was developed with a high EcoScale and yields.
Mekheimer Ramadan Ahmed, Hayallah Alaa M., Moustafa Moustafa Sherief, Al-Mousawi Saleh Mohammed, Abd-Elmonem Mohamed, Mostafa Sara M., Abo Elsoud Fatma A., Sadek Kamal Usef   +7 more
doaj   +1 more source

Salification Controls the In-Vitro Release of Theophylline

Crystals, 2022
Sustained released formulation is the most used strategy to control the efficacy and the adverse reactions of an API (active pharmaceutical ingredient) with a narrow therapeutic index.
Laura Baraldi, Luca Fornasari, Irene Bassanetti, Francesco Amadei, Alessia Bacchi, Luciano Marchiò   +5 more
doaj   +1 more source

Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary ...
K. V. Aleksandrova, Ye. S. Pruhlo, Ye. K. Mykhalchenko, O. S. Shkoda, O. Yu. Cherchesova   +4 more
doaj   +1 more source

Towards Splicing Therapy for Lysosomal Storage Disorders: Methylxanthines and Luteolin Ameliorate Splicing Defects in Aspartylglucosaminuria and Classic Late Infantile Neuronal Ceroid Lipofuscinosis

Cells, 2021
Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
doaj   +1 more source

Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

Zaporožskij Medicinskij Žurnal, 2021
Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai, M. I. Romanenko, D. H. Ivanchenko   +2 more
doaj   +1 more source