Results 21 to 30 of about 44,980 (368)

Xanthine scaffold: available synthesis routes to deliver diversity by derivatization [PDF]

, 2021
The functionalization of the skeletal systems of heterocycles represents a significant goal for the development of new compounds. The heterocyclic molecule xanthine (3,7-dihydro-1Hpurine- 2,6-dione) is a purine base with a bicyclic ring skeleton and ...
Isabella Chiarotto, Leonardo Mattiello, Marta Feroci, Rita Petrucci   +3 more
core   +1 more source

Design, synthesis and evaluation of semi- and thiosemicarbazides containing a methylxanthine moiety with in vitro neuroprotective and MAO-B inhibitory activities

Biotechnology & Biotechnological Equipment, 2022
This study is focused on determination of the most appropriate synthetic approach for obtaining series of theophylline-7-acetyl semi- and thiosemicarbazide hybrids by using the molecular hybridization strategy with and without a catalyst.
Javor Mitkov, Magdalena Kondeva-Burdina, Lily Peikova, Maya Georgieva, Alexander Zlatkov   +4 more
doaj   +1 more source

Q-Tube®-Assisted Alkylation and Arylation of Xanthines and Other N-H-Containing Heterocycles in Water

Chemistry, 2021
In this paper, a simple and clean process for the alkylation and arylation of nitrogen-containing heterocycles is reported. The reactions were conducted using the Q-tube® as a non-conventional technology, in water as a green solvent, at overboiling ...
Cecilia Scimmi, Margherita Cardinali, Laura Abenante, Marina Amatista, Francesca Giulia Nacca, Eder J. Lenardao, Luca Sancineto, Claudio Santi   +7 more
doaj   +1 more source

Facile N9-Alkylation of Xanthine Derivatives and Their Use as Precursors for N-Heterocyclic Carbene Complexes

Molecules, 2021
The xanthine-derivatives 1,3,7-trimethylxanthine, 1,3-dimethyl-7-benzylxanthine and 1,3-dimethyl-7-(4-chlorobenzyl)xanthine are readily ethylated at N9 using the cheap alkylating agents ethyl tosylate or diethyl sulfate. The resulting xanthinium tosylate
Moloud Mokfi, Jörg Rust, Christian W. Lehmann, Fabian Mohr   +3 more
doaj   +1 more source

Towards Splicing Therapy for Lysosomal Storage Disorders: Methylxanthines and Luteolin Ameliorate Splicing Defects in Aspartylglucosaminuria and Classic Late Infantile Neuronal Ceroid Lipofuscinosis

Cells, 2021
Splicing defects caused by mutations in the consensus sequences at the borders of introns and exons are common in human diseases. Such defects frequently result in a complete loss of function of the protein in question.
Antje Banning, Ritva Tikkanen
doaj   +1 more source

Salification Controls the In-Vitro Release of Theophylline

Crystals, 2022
Sustained released formulation is the most used strategy to control the efficacy and the adverse reactions of an API (active pharmaceutical ingredient) with a narrow therapeutic index.
Laura Baraldi, Luca Fornasari, Irene Bassanetti, Francesco Amadei, Alessia Bacchi, Luciano Marchiò   +5 more
doaj   +1 more source

Xanthine dehydrogenase/xanthine oxidase and oxidative stress [PDF]

AGE, 1997
Xanthine dehydrogenase (XDH) and xanthine oxidase (XOD) are single-gene products that exist in separate but interconvertible forms. XOD utilizes hypoxanthine or xanthine as a substrate and O2 as a cofactor to produce superoxide (·O2 (-)) and uric acid.
Hae Young Chung, Myoung Sook Kim, Jung Im Huh, Kyung Hee Shim, Kyu-Won Kim, Kyung Hee Lee, Sang Ho Song, Bong Sook Baek   +7 more
openaire   +2 more sources

Study on the influence of 7-β-hydroxy-γ-aryloxypropylxanthinyl-8-thioalkanic acid derivatives on the lipid metabolism in experiment

Zaporožskij Medicinskij Žurnal, 2021
Statin side effects are not a rare occurrence, in particular dyspeptic disorders, insomnia, headache, skin erythema, rash are often noted. All of this determines scientists to find new effective and low-toxic hypolipidemic agents.
I. M. Bilai, M. I. Romanenko, D. H. Ivanchenko   +2 more
doaj   +1 more source

Xanthine urolithiasis: Inhibitors of xanthine crystallization

PLOS ONE, 2018
AbstractOBJECTIVETo identify in vitro inhibitors of xanthine crystallization that have potential for inhibiting the formation of xanthine crystals in urine and preventing the development of the renal calculi in patients with xanthinuria.METHODSThe formation of xanthine crystals in synthetic urine and the effects of 10 potential crystallization ...
Grases, Felix, Costa-Bauza, Antonia, Roig, Joan, Rodriguez, Adrian   +3 more
openaire   +7 more sources

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source