Results 11 to 20 of about 4,620 (190)

The multifaceted role of XCL1 in health and disease. [PDF]

Protein Sci
The chemokine XC motif chemokine ligand 1 (XCL1) is an unusually specialized member of a conserved family of around 50 small, secreted proteins that are best known for their ability to stimulate the directional migration of cells.
Syed M, Dishman AF, Volkman BF, Walker TL.   +3 more
europepmc   +4 more sources

Resurrected Ancestors Reveal Origins of Metamorphism in XCL1 [PDF]

Trends in Biochemical Sciences, 2021
In a recent study, Dishman et al. resurrected ancestors of the metamorphic chemokine, XCL1, inferred through phylogenetics, and found that metamorphism arose in the XCL1 lineage ~150 million years ago.
Patricia J. LiWang, Lee‐Ping Wang, Andy LiWang   +2 more
semanticscholar   +7 more sources

Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer [PDF]

Cancer Immunology, Immunotherapy
Background Dendritic cells (DCs) derived extracellular vesicles represent a promising vehicle for the activation of adaptive immunity, demonstrating significant potential in the development of cancer nanovaccines.
Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu   +6 more
doaj   +3 more sources

Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants [PDF]

Vaccines
Background: Human papillomavirus (HPV) is a prevalent infection affecting both men and women, leading to various cytological lesions. Therapeutic vaccines mount a HPV-specific CD8+ cytotoxic T lymphocyte response, thus clearing HPV-infected cells ...
Zhongjie Sun, Zhongyan Wu, Xuncheng Su
doaj   +3 more sources

Immunogenicity of the Xcl1-SARS-CoV-2 Spike Fusion DNA Vaccine for COVID-19

Vaccines, 2022
SARS-CoV-2 spike (S) variants that may evade antibody-mediated immunity are emerging. Evidence shows that vaccines with a stronger immune response are still effective against mutant strains. Here, we report a targeted type 1 conventional dendritic (cDC1)
Hailong Qi, Zhongjie Sun, Yanling Yao, Ligong Chen, Xuncheng Su   +4 more
doaj   +4 more sources

Efficacy and immunomodulatory effect of Claudin18.2-specific IL-7/XCL1 armored CAR-T cells in digestive tract cancer: preclinical and clinical analysis. [PDF]

Signal Transduct Target Ther
Chimeric antigen receptor (CAR)-T cell therapy exerts limited therapeutic efficacy in solid tumors including digestive tract cancer (DTC), which is largely attributable to the suppressive tumor microenvironment (TME) and the functional deficits of CAR-T ...
Zhao X, Liu J, Zhang Z, Zhou Y, Jin S, Zong H, Wang F, Song M, Zhong Y, Li Q, Pei B, Yu Y, Gao M, Ge W, Han L, Ren J, Zhang Y.   +16 more
europepmc   +4 more sources

Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes [PDF]

Pharmacological Reports, 2020
Every year, millions of people suffer from various forms of traumatic brain injury (TBI), and new approaches with therapeutic potential are required.
Agata Ciechanowska, Katarzyna Popiolek-Barczyk, Katarzyna Ciapała   +2 more
exaly   +4 more sources

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy [PDF]

Advanced Science
Conventional type 1 dendritic cells (cDC1s) play a crucial role in initiating and regulating antitumor immunity. However, the insufficient infiltration and dysfunctional state of these cells within the tumor microenvironment hinder antitumor immune ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
doaj   +3 more sources

The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1. [PDF]

PLoS Pathogens, 2013
CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors.
Christina Guzzo, Jamie Fox, Yin Lin, Huiyi Miao, Raffaello Cimbro, Brian F Volkman, Anthony S Fauci, Paolo Lusso   +7 more
doaj   +5 more sources

Transcutaneous immunization with a highly active form of XCL1 as a vaccine adjuvant using a hydrophilic gel patch elicits long-term CD8+ T cell responses

Journal of Pharmacological Sciences, 2020
Memory CD8+ cytotoxic T-lymphocytes (CTLs) play a key role in protective immunity against infection and cancer. However, the induction of memory CTLs with currently available vaccines remains difficult.
Momo Kamei, Kazuhiko Matsuo, Haruka Imanishi, Yuta Hara, Ying-Shu Quen, Fumio Kamiyama, Naoki Oiso, Akira Kawada, Naoki Okada, Takashi Nakayama   +9 more
doaj   +3 more sources