Results 21 to 30 of about 4,620 (190)

Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1 [PDF]

ACS Infectious Diseases, 2020
Antimicrobial peptides (AMPs) are a class of molecules which generally kill pathogens via preferential cell membrane disruption. Chemokines are a family of signaling proteins that direct immune cell migration and share a conserved α–β tertiary structure.
Acacia F Dishman, Michelle W Lee, Jaime de Anda   +2 more
exaly   +5 more sources

A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells

Frontiers in Immunology, 2018
The chemokine receptor XCR1 is known to be selectively expressed by cross-presenting dendritic cells (DCs), while its ligand XCL1/lymphotactin is mainly produced by activated CD8+ T cells and natural killer cells.
Naoki Oiso, Osamu Yoshie
exaly   +4 more sources

Diepoxybutane induces the expression of a novel p53‐target gene XCL1 that mediates apoptosis in exposed human lymphoblasts

Journal of Biochemical and Molecular Toxicology, 2020
Diepoxybutane (DEB) is the most potent active metabolite of the environmental chemical 1,3‐butadiene (BD). BD is a human carcinogen that exhibits multiorgan systems toxicity.
Akamu J. Ewunkem, Maya Deve, Scott H. Harrison, Perpetua M. Muganda   +3 more
semanticscholar   +6 more sources

Engineering Metamorphic Chemokine Lymphotactin/XCL1 into the GAG-Binding, HIV-Inhibitory Dimer Conformation [PDF]

ACS Chemical Biology, 2015
Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, whereas the dimer binds extracellular matrix glycosaminoglycans and has been associated with anti-human immunodeficiency virus (HIV ...
Jamie Fox, Robert C. Tyler, Christina Guzzo, Robbyn L. Tuinstra, Francis C. Peterson, Paolo Lusso, Brian F. Volkman   +6 more
openalex   +4 more sources

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10 [PDF]

Journal for ImmunoTherapy of Cancer, 2020
Background Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8+ T and natural killer (NK) cells. Bioactive IL-15 is produced in the body as a heterodimeric cytokine, comprising the IL-15 and IL-15 receptor alpha chains (hetIL-15 ...
Cristina Bergamaschi, Hrishikesh Pandit, Bethany A. Nagy, Dimitris Stellas, Shawn M. Jensen, Jenifer Bear, Maggie Cam, Antonio Valentin, Bernard A. Fox, Barbara K. Felber, George N. Pavlakis   +10 more
openalex   +2 more sources

The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model [PDF]

International Journal of Molecular Sciences
With the advent of cancer immunotherapy, there is a growing interest in vaccine development as a means to activate the cellular immune system against cancer.
Ke Zhang, Qimuge Wuri, Zongyu Cai, Xueli Qu, Shiqi Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Xianghui Yu, Wei Kong, Haihong Zhang   +10 more
openalex   +2 more sources

Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression [PDF]

eLife
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions.
Tianhan Li, Liaoxun Lu, Juanjuan Qiu, Xin Dong, Le Yang, Kexin He, Yanrong Gu, Binhui Zhou, Tingting Jia, Toby Lawrence, Marie Malissen, Guixue Wang, Rong Huang, Hui Wang, Bernard Malissen, Yinming Liang, Lichen Zhang   +16 more
doaj   +2 more sources

XCL1 facilitates the interaction with CD8+ T-cells and XCR1+ DCs within the Cervical Lymph Nodes during WNV encephalitis [PDF]

Journal of Immunology, 2023
West Nile Virus (WNV), a neurotropic flavivirus, causes encephalitis, especially in elderly and immunocompromised individuals. Previous studies have demonstrated that CNS-localized dendritic cells (DCs) protect against WNV neuroinvasive disease by ...
Kristen De La Torre, Douglas M. Durrant
openalex   +2 more sources

Synergistic Enhancement of <i>Eimeria maxima</i> Vaccine Efficacy Through EF-1α Antigen and Chicken XCL1 Chemokine Adjuvant Combination. [PDF]

Animals (Basel)
Simple Summary Chicken coccidiosis is caused by Eimeria parasites; this disease can lead to reduced productivity and economic losses. The current primary strategies for controlling Eimeria parasites involve administering anticoccidial drugs or live ...
Chen R, Lin XF, Wu HY, Li LN, Wang L, Wang DF, Wu HY, Guo PP, Mohsin M, Yin GW.   +9 more
europepmc   +2 more sources

The Identification and Distribution of Cattle XCR1 and XCL1 among Peripheral Blood Cells: New Insights into the Design of Dendritic Cells Targeted Veterinary Vaccine. [PDF]

PLoS ONE, 2017
The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and XCL1 and their distribution among peripheral blood ...
Kun Li, Guoyan Wei, Yimei Cao, Dong Li, Pinghua Li, Jing Zhang, Huifang Bao, Yingli Chen, Yuanfang Fu, Pu Sun, Xingwen Bai, Xueqing Ma, Zengjun Lu, Zaixin Liu   +13 more
doaj   +3 more sources