Results 31 to 40 of about 4,620 (190)
Advanced ScienceTrophoblast–immune cell communication is crucial during pregnancy, with impairments linked to adverse outcomes. The accumulation of decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) in the third trimester is vital for fetal ...
Meiqi Chen +12 more
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Chlorine-Rich Na6−xPS5−xCl1+x: A Promising Sodium Solid Electrolyte for All-Solid-State Sodium Batteries [PDF]
MaterialsDeveloping argyrodite-type, chlorine-rich, sodium-ion, solid-state electrolytes with high conductivity is a long-term challenge that is crucial for the advancement of all-solid-state batteries (ASSBs).
Yi Zhang +6 more
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A Requirement for Metamorphic Interconversion in the Antimicrobial Activity of Chemokine XCL1 [PDF]
Biochemistry, 2016 Chemokines make up a superfamily of ∼50 small secreted proteins (8-12 kDa) involved in a host of physiological processes and disease states, with several previously shown to have direct antimicrobial activity comparable to that of defensins in efficacy.
Amanda M. Nevins +7 more
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Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets [PDF]
Frontiers in PediatricsPediatric sepsis is a serious condition causing organ failure owing to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment.
Yue-chuan Shen +4 more
doaj +2 more sources
Biochimica et biophysica acta. Molecular cell researchXC Motif Chemokine Ligand 1 (XCL1, known as lymphotactin), acting via XCR1, is a member of the chemokine family which includes molecules with chemotactic functions.
A Ciechanowska, Joanna Mika
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Expression and Function of the C-Class Chemokine Lymphotactin (XCL1) in Wegener’s Granulomatosis [PDF]
The Journal of Rheumatology, 2009 Objective.In Wegener’s granulomatosis (WG), vasculitic lesions are characterized by prominent infiltration of polymorphonuclear neutrophils (PMN) and T cells, but underlying pathogenic mechanisms remain to be defined. We analyzed the expression and functional role of the C-class chemokine lymphotactin, XCL1, in WG.Methods.Sera and peripheral blood ...
Sabine Blaschke +3 more
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Specific binding‐induced modulation of the
Biopolymers, 2020 AbstractThe metamorphic protein XCL1 switches between two distinct native structures with different functions in the human immune system. This structural interconversion requires complete rearrangement of all hydrogen bonding networks, yet fold‐switching occurs spontaneously and reversibly in solution. One structure occupies the canonical α‐β chemokine
Acacia F. Dishman +2 more
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Inflammatory response in traumatic brain and spinal cord injury: The role of XCL1-XCR1 axis and T cells. [PDF]
CNS Neurosci TherTraumatic brain injury (TBI) and spinal cord injury (SCI) are acquired injuries to the central nervous system (CNS) caused by external forces that cause temporary or permanent sensory and motor impairments and the potential for long‐term disability or ...
Zhang M +10 more
europepmc +2 more sources
XCL1 Enhances Regulatory Activities of CD4+CD25highCD127low/− T Cells in Human Allergic Asthma [PDF]
The Journal of Immunology, 2008 Abstract Chemokine-mediated recruitment of regulatory cell subsets to the airway during inflammation and enhancement of their activities are potential strategies for therapeutic development in allergic asthma (AA). In this study, we aim to explore the role of XCL1, a chemokine associated with immune suppression and allergy, on CD4 ...
Khoa D. Nguyen +5 more
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γδ T Cell–Secreted XCL1 Mediates Anti-CD3–Induced Oral Tolerance [PDF]
The Journal of Immunology, 2019 Key Points Oral anti-CD3 induces gut lamina propria γδ T cells to produce XCL1. XCL1-activated CCR7+XCR1+ cDCs migrate to the mLN. In the mLN, Treg cells are induced and oral tolerance is established.
R. Rezende +11 more
semanticscholar +3 more sources