Results 41 to 50 of about 4,620 (190)

A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability [PDF]

Neuroscience, 2018
Chemokines are known to have a role in the nervous system, influencing a range of processes including the development of chronic pain. To date there are very few studies describing the functions of the chemokine lymphotactin (XCL1) or its receptor (XCR1) in the nervous system.
Emma V. Bird, Tommaso Iannitti, Claire R. Christmas, Ilona Obara, Veselin I. Andreev, Anne E. King, Fiona M. Boissonade   +6 more
openalex   +4 more sources

Single-Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease. [PDF]

Adv Sci (Weinh)
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Zhou X, Cong J, Peng R, Yang D, Dong C, Xie J, Yan J, Kuang J, Li F, Yeap LS, Xie X, Yin H, Han R, Shen L, Zhou Y, Ning G, Wang S, Wang W, Ye L.   +18 more
europepmc   +2 more sources

A functional variant near XCL1 gene improves breast cancer survival via promoting cancer immunity [PDF]

International Journal of Cancer, 2020
Most genome‐wide association studies (GWASs) identify genetic variants for breast cancer occurrence. In contrast, few are for recurrence and mortality. We conducted a GWAS on breast cancer survival after diagnosis in estrogen receptor‐positive patients ...
Wen-Cheng Chou, Chia-Ni Hsiung, Wei-Ting Chen, L. Tseng, Hui-Chun Wang, Hou-Wei Chu, M. Hou, Jyh-Cherng Yu, Chen-Yang Shen   +8 more
semanticscholar   +3 more sources

Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance [PDF]

Journal of Inflammation Research
Yiyu Hong,* Qiutong Chen,* Hua Xie, Mingliu Ma, Siting Gan, Yuqi Zhang, Zhaozhong Xu Department of Emergency, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China*These authors contributed equally ...
Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z   +6 more
doaj   +2 more sources

Macrophages in tertiary lymphoid structures promote apoptosis of ATF4-positive gastric cancer cells via IL18 [PDF]

Journal of Translational Medicine
Background Gastric cancer (GC) is a globally prevalent and highly fatal malignancy of the digestive system. Despite its transformative role in gastric cancer, immunotherapy’s efficacy is limited by the complexity and incomplete understanding of the ...
Lu Zhou, Xuelong Li, Junming Wu, Tianqing Zheng, Manru Lin, Yangjian Ou, Hong Zhou, Steven Mo, Xueqiong Han, Jinyu Xiang, Wenjing Gong   +10 more
doaj   +2 more sources

XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary [PDF]

Oncogene, 2020
Molecular characteristics of carcinoma arising from mature cystic teratoma of the ovary (MCT) remain unclear due to its rarity. We analyzed RNA-sequencing data of 2322 pan-cancer [1378 squamous cell carcinomas (SCC), 6 adenosquamous carcinomas (ASC), and
Ryo Tamura, Kosuke Yoshihara, Hirofumi Nakaoka, Nozomi Yachida, Manako Yamaguchi, Kazuaki Suda, Tatsuya Ishiguro, Koji Nishino, Hiroshi Ichikawa, Keiichi Homma, Akira Kikuchi, Yutaka Ueda, Yuji Takei, Hiroyuki Fujiwara, Teiichi Motoyama, Shujiro Okuda, Toshifumi Wakai, Ituro Inoue, Takayuki Enomoto   +18 more
openalex   +2 more sources

The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells

Frontiers in Immunology, 2012
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation.
Richard A. Kroczek, Volker eHenn
exaly   +3 more sources

The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma [PDF]

Nature Communications
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies.
Guozhong Jiang, Zhizhong Wang, Zhenguo Cheng, Weiwei Wang, Shuangshuang Lu, Zifang Zhang, Chinedu A. Anene, Faraz Khan, Yue Chen, Emma Bailey, Huisha Xu, Yunshu Dong, Peinan Chen, Zhongxian Zhang, Dongling Gao, Zhimin Wang, Jinxin Miao, Xia Xue, Pengju Wang, Lirong Zhang, Rathi Gangeswaran, Peng Liu, Louisa S. Chard Dunmall, Junkuo Li, Yongjun Guo, Jianzeng Dong, Nicholas R. Lemoine, Wencai Li, Jun Wang, Yaohe Wang   +29 more
doaj   +2 more sources

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1 [PDF]

Science Signaling, 2019
Key amino acids in the chemokine XCL1 mediate its specificity for and activation of its receptor XCR1. Modeling ligand-receptor specificity Ligand-receptor interactions trigger many cellular behaviors and changes that underlie various physiologic ...
Jamie C. Fox, Monica A. Thomas, Acacia F. Dishman, Olav Larsen, T. Nakayama, O. Yoshie, M. Rosenkilde, B. Volkman   +7 more
semanticscholar   +5 more sources

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity [PDF]

Signal Transduction and Targeted Therapy
Severe cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease
Lele Sun, Pengcheng Huai, Zhenzhen Wang, Qing Zhao, Yingjie Lin, Tingting Liu, Xiaotong Xue, Suiting Ao, Jiabao You, Yonghu Sun, Zihao Mi, Joshua Gardner, Paul J. Thomson, Dean J. Naisbitt, Xiaoli Meng, Jianjun Liu, Hong Liu, Furen Zhang   +17 more
doaj   +2 more sources