Results 51 to 60 of about 4,620 (190)

Progress in research on C-chemokine XCL1

World Chinese Journal of Digestology, 2017
Lei Yu, Yang Guibo
openalex   +2 more sources

Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1 [PDF]

Molecular Therapy, 2016
Sang Eon Park, Min-jeong Kim, Na Kyung Lee   +2 more
exaly   +2 more sources

Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy [PDF]

Journal for ImmunoTherapy of Cancer
Background The interleukin (IL)-1-family receptor antagonist IL-38 has emerged as a negative regulator of auto-inflammation. Given the intricate interplay between antitumor immunity and auto-inflammation, we hypothesized that blocking IL-38 may enhance ...
Andreas Ernst, Andreas Weigert, Priscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Bernhard Bruene   +9 more
doaj   +2 more sources

IL-18-primed NK cells recruit dendritic cells and potentiate tumor therapy mediated by PD-1 blockade [PDF]

Frontiers in Oncology
The success of cancer immunotherapy depends on the effective coordination of innate and adaptive immunity. We previously reported that IL-18 potentiates the therapeutic effects of immune checkpoint inhibitors in mouse models.
Yoshiya Ohno, Haruki Okamura, Hideo Yagita, Toshiyuki Tanaka   +3 more
doaj   +2 more sources

XCL1 Gene

, 2020
National Cancer Institute
openalex   +2 more sources

Targeting Xcr1 on Dendritic Cells Rapidly Induce Th1-Associated Immune Responses That Contribute to Protection Against Influenza Infection

Frontiers in Immunology, 2022
Targeting antigen to conventional dendritic cells (cDCs) can improve antigen-specific immune responses and additionally be used to influence the polarization of the immune responses. However, the mechanisms by which this is achieved are less clear.
Demo Yemane Tesfaye, Demo Yemane Tesfaye, Sonja Bobic, Sonja Bobic, Anna Lysén, Anna Lysén, Peter Csaba Huszthy, Peter Csaba Huszthy, Arnar Gudjonsson, Arnar Gudjonsson, Ranveig Braathen, Ranveig Braathen, Bjarne Bogen, Bjarne Bogen, Bjarne Bogen, Even Fossum, Even Fossum   +16 more
doaj   +1 more source

Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer [PDF]

Biochemistry, 2016
Known for its distinct metamorphic behavior, XCL1 interconverts between a canonical chemokine folded monomer (XCL1mon) that interacts with the receptor, XCR1, and a unique dimer (XCL1dim) that interacts with glycosaminoglycans and inhibits HIV-1 activity. This study presents the first detailed analysis of the GAG binding properties of XCL1dim.
Fox, Jamie C, Tyler, Robert C, Peterson, Francis C, Dyer, Douglas P, Zhang, Fuming, Linhardt, Robert J, Handel, Tracy M, Volkman, Brian F   +7 more
openaire   +5 more sources

Production of biologically active human lymphotactin (XCL1) by Lactococcus lactis [PDF]

Biotechnology Letters, 2008
Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. We expressed human lymphotactin (LTN) by the lactic-acid bacterium Lactococcus lactis. Biological activity of LTN was confirmed by chemo-attraction of human T-cells by chemotaxis demonstrating, for
Zavala Flores, Laura Mireya, Villatoro Hernández, Julio, Gámez Escobedo, Idalia Analí, Franco Molina, Moisés Armides, Rangel Colmenero, Blanca Rocío, Villanueva Olivo, Arnulfo, Gutiérrez Puente, Yolanda, Montes de Oca Luna, Roberto, Valdés Flores, Jesús, Saucedo Cárdenas, Odila   +9 more
openaire   +2 more sources

Crowded environments tune the fold-switching in metamorphic proteins

Communications Chemistry, 2023
Metamorphic proteins such as circadian clock protein KaiB and human chemokine XCL1 play vital roles in regulating biological processes, including gene expression, circadian clock and innate immune responses, and perform distinct functions in living cell ...
Ning Zhang, Wenyan Guan, Shouqi Cui, Nana Ai   +3 more
doaj   +1 more source

Dendritic cell-targeting chemokines inhibit colorectal cancer progression

Exploration of Targeted Anti-tumor Therapy, 2022
Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating adaptive anti-tumor immunity ...
Pengkun Yuan, Yunyi Zhou, Zhixue Wang, Liming Gui, Bin Ma   +4 more
doaj   +1 more source