Results 61 to 70 of about 4,620 (190)

Depot-specific inflammation with decreased expression of ATM2 in white adipose tissues induced by high-margarine/lard intake. [PDF]

open access: yesPLoS ONE, 2017
A high-fat diet has been recognized as an important risk factor of obesity, with variable impacts of different fatty acid compositions on the physiological process. To understand the effects of a high-margarine/lard diet, which is a major source of trans
Nannan Wang   +8 more
doaj   +1 more source

Struktur-Funktionsanalyse des Chemokins XCL1

open access: yes, 2021
Einleitung Chemokine vermitteln die Interaktion von Immunzellen. Das Chemokin XCL1 wird von aktivierten CD8+ T-Zellen und NK-Zellen sezerniert und besitzt die für Chemokine typische Tertiärstruktur, bestehend aus einem N-Terminus, einem antiparallelen β-Faltblatt, einer α Helix und einem freien C-Terminus von etwa 20 Aminosäuren.
openaire   +2 more sources

A novel predictive model for the recurrence of pediatric alopecia areata by bioinformatics analysis and a single-center prospective study

open access: yesFrontiers in Medicine, 2023
BackgroundAlopecia areata (AA) is a disease featured by recurrent, non-scarring hair loss with a variety of clinical manifestations. The outcome of AA patients varies greatly.
Yuanquan Zheng   +4 more
doaj   +1 more source

Rat cytomegalovirus efficiently replicates in dendritic cells and induces changes in their transcriptional profile

open access: yesFrontiers in Immunology, 2023
Dendritic cells (DC) play a crucial role in generating and maintaining antiviral immunity. While DC are implicated in the antiviral defense by inducing T cell responses, they can also become infected by Cytomegalovirus (CMV).
Julia Cecilia Madela-Mönchinger   +9 more
doaj   +1 more source

Aberrant Tissue Positioning of Metallophilic Macrophages in the Thymus of XCL1‐Deficient Mice [PDF]

open access: yesThe Anatomical Record, 2014
ABSTRACTMetallophilic macrophages hold a strategic position within the thymic tissue and play a considerable function in thymic physiology. The development and positioning of these cells within thymic tissue are regulated by complex molecular mechanisms involving different cytokine/chemokine axes.
Novica M. Milićević   +6 more
openaire   +2 more sources

Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection

open access: yesCell Reports, 2023
Summary: Bordetella spp. are respiratory pathogens equipped with immune evasion mechanisms. We previously characterized a Bordetella bronchiseptica mutant (RB50ΔbtrS) that fails to suppress host responses, leading to rapid clearance and long-lasting ...
Nicholas J. First   +9 more
doaj   +1 more source

Enhanced ion conduction by enforcing structural disorder in Li-deficient argyrodites Li6−xPS5−xCl1+x

open access: yes, 2020
Solid electrolytes with high ionic conductivity and good stability are advantageous over the current liquid electrolytes in rechargeable Li-ion batteries.
Xuyong Feng   +7 more
semanticscholar   +1 more source

Comprehensive identification of onco-exaptation events in bladder cancer cell lines revealed L1PA2-SYT1 as a prognosis-relevant event

open access: yesiScience, 2023
Summary: Transposable elements (TEs) can provide ectopic promoters to drive the expression of oncogenes in cancer, a mechanism known as onco-exaptation.
Ziwei Wang   +9 more
doaj   +1 more source

Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

open access: yesClinical and Translational Medicine, 2021
Profiling heterologous cell types within tumors is essential to decipher tumor microenvironment that shapes tumor progress and determines the outcome of therapeutic response.
Yan Mei   +17 more
doaj   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto   +20 more
wiley   +1 more source

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