Results 101 to 110 of about 7,624 (217)

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

Frontiers in Immunology, 2019
Granzyme A (GzmA), together with perforin, are well-known for their cytotoxic activity against tumor or virus-infected cells. In addition to this cytotoxic function, GzmA stimulates several immune cell types and induces inflammation in the absence of ...
Kanako Shimizu, Satoru Yamasaki, Maki Sakurai, Noriko Yumoto, Mariko Ikeda, Chiemi Mishima-Tsumagari, Mutsuko Kukimoto-Niino, Takashi Watanabe, Masami Kawamura, Mikako Shirouzu, Shin-ichiro Fujii   +10 more
doaj   +1 more source

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]

, 2014
Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain, Bain, Barclay, Barclay, Basu, Bimczok, Bogunovic, Cerovic, Cerovic, Coombes, del Rio, Fortin, Fukunaga, Goto, Inagaki, Iwamura, Kanazawa, Latour, Lewis, Lindberg, Liu, Lécuyer, Matozaki, Matteoli, Milling, Motegi, Naik, Okuzawa, Pabst, Persson, Persson, Raymond, Raymond, Saito, Satpathy, Schlitzer, Schraml, Schulz, Scott, Scott, Sun, Takai, Tamoutounour, Tomizawa, Varol, Waclavicek, Watchmaker, Welty, Westlund   +48 more
core   +2 more sources

Type 1 and CD103+ Type 2 Conventional Dendritic Cells Are Decreased in Active Patients with Ulcerative Colitis but Not with Crohn's Disease

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Human lamina propia mononuclear cells (LPMC) were isolated from intestinal biopsies and resections, as well as peripheral blood mononuclear cells (PBMC) from blood. Using flow cytometry approaches, we characterized cDC subsets and assessed their functional capacity through T‐cell coculture assays (after isolation of the different subsets of cDC using ...
Elisa Arribas‐Rodríguez, Carolina G. de Castro, Aida Fiz‐López, Ángel De Prado, Álvaro Martín‐Muñoz, Luis Fernández Salazar, Jesús Barrio, Sandra Izquierdo, Javier García Alonso, Beatriz de Andrés, José María García‐Abril, Alejandro Romero, Javier Sánchez González, Cecilio Santander, Eduardo Arranz, María Chaparro, José A. Garrote, Javier P. Gisbert, David Bernardo   +18 more
wiley   +1 more source

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity

Cell Reports, 2018
Summary: The ability to generate large numbers of distinct types of human dendritic cells (DCs) in vitro is critical for accelerating our understanding of DC biology and harnessing them clinically. We developed a DC differentiation method from human CD34+
Sreekumar Balan, Catharina Arnold-Schrauf, Abdenour Abbas, Norbert Couespel, Juliette Savoret, Francesco Imperatore, Alexandra-Chloé Villani, Thien-Phong Vu Manh, Nina Bhardwaj, Marc Dalod   +9 more
doaj   +1 more source

Transcriptional patterns associated with BDCA3 expression on BDCA1+ myeloid dendritic cells [PDF]

, 2018
Myeloid dendritic cells, including BDCA3hi DCs and BDCA1+ DCs (hereafter dubbed DC1 and DC2 for clarity), play a pivotal role in the induction and regulation of immune responses. Interestingly, a fraction of DC2 also express low to intermediate levels of
Aa, Aa, Bouchon, Cabec, Chen, Conway, Crozat, Crozat, Dzionek, Grajales-Reyes, Grey, Haniffa, Jaiswal, Li, Lindstedt, Lowell, Merad, Murphy, Poulin, Segura, Steinman, Subramanian, Tamura, Van De Wouwer, Williams, Worah, Yerkovich, Zhang   +27 more
core   +3 more sources

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Dendritic Cell Subtypes from Lymph Nodes and Blood Show Contrasted Gene Expression Programs upon Bluetongue Virus Infection [PDF]

, 2013
Chantier qualité GAHuman and animal hemorrhagic viruses initially target dendritic cells (DCs). It has been proposed, but not documented, that both plasmacytoid DCs (pDCs) and conventional DCs (cDCs) may participate in the cytokine storm encountered in ...
Baranek T, Barratt-Boyes SM, Barratt-Boyes SM, Benjamini Y, Cisse B, Conraths FJ, Contreras V, Crozat K, De Carvalho Bittencourt M, DeMaula CD, Diana J, Diana J, Drew CP, Duan XZ, Elbers AR, Geisbert TW, Gowen BB, Guillerey C, Hensley LE, Hensley LE, Kanto T, Karsunky H, Kyle JL, MacLachlan NJ, MacLachlan NJ, Mellor AL, Moulin V, Niessen F, Pacheco R, Pascale F, Perrin A, Pichyangkul S, Sauer AV, Schwartz-Cornil I, Swiecki M, Szatmari I, Takamatsu H, Top S, Umemoto E, Umeshappa CS, Veronesi E, Wahli W, Wilson AJ, Zucchini N   +43 more
core   +4 more sources

Traumatic brain injury in mice induces changes in the expression of the XCL1/XCR1 and XCL1/ITGA9 axes

Pharmacological Reports, 2020
Every year, millions of people suffer from various forms of traumatic brain injury (TBI), and new approaches with therapeutic potential are required.
Agata Ciechanowska, K. Popiołek-Barczyk, Katarzyna Ciapała, K. Pawlik, M. Oggioni, D. Mercurio, M. D. De Simoni, J. Mika   +7 more
semanticscholar   +1 more source

Endothelium‐Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Here, we reveal that pulmonary endothelium‐derived EVs aggravate lung inflammation via destabilizing Tregs during ALI/ARDS. Mechanistically, Tregs absorbs EV‐Med1, which promotes the secretion of IL‐21. This cytokine in turn induces hyper‐phosphorylation of STAT3 in Tregs thus induing loss of Foxp3, creating an hyperinflammatory ALI/ARDS ...
Xu Liu, Wei Huang, Xiwen Zhang, Shiming Li, Haofei Wang, Zongsheng Wu, Shuangfeng Zi, Lu Wang, Ling Liu, Yi Yang, Jianfeng Xie, Mingzhu Zheng, Jie Chao, Haibo Qiu   +13 more
wiley   +1 more source

Systematic pan-cancer analysis reveals XCR1 as a Prognostic and Immunological Biomarker

, 2023
Abstract Background Chemokines and their receptors play an important role in immune monitoring and immune defense during the tumor growth and metastasis. However, their prognostic roles in pan-cancer were not elucidated. In this work, we screened all chemokine receptors in pan-cancer and discovered XCR1 as a reliable immunological and ...
Likun Cui, Jie Chen, Chunzhen Li, Yizhi Yu, Sheng Xu   +4 more
openaire   +1 more source