Results 191 to 200 of about 7,941 (215)

YTHDF1 facilitates PRC1‐mediated H2AK119ub in human ES cells

Journal of Cellular Physiology, 2023
AbstractPolycomb repressive complexes (PRCs) play critical roles in cell fate decisions during normal development as well as disease progression through mediating histone modifications such as H3K27me3 and H2AK119ub. How exactly PRCs recruited to chromatin remains to be fully illuminated.
Jingyuan Zhang, Tianyu Wang, Ruona Shi, Yuan Zhao, Yanqi Zhang, Cong Zhang, Qi Xing, Tiancheng Zhou, Yongli Shan, Hongjie Yao, Xiaofei Zhang, Guangjin Pan   +11 more
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YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7

Cancer Research, 2020
Abstract N6-methyladenosine (m6A) is the most prevalent internal RNA modification in mammals that regulates homeostasis and function of modified RNA transcripts. Here, we aimed to investigate the role of YTH m6A RNA-binding protein 1 (YTHDF1), a key regulator of m6A methylation in gastric ...
Jingnan Pi, Wen Wang, Ming Ji, Xiaoshuang Wang, Xueju Wei, Jing Jin, Tao Liu, Jiaqi Qiang, Zhihong Qi, Feng Li, Yue Liu, Yanni Ma, Yanmin Si, Yue Huo, Yufeng Gao, Yiying Chen, Lei Dong, Rui Su, Jianjun Chen, Shuan Rao, Ping Yi, Shuyang Yu, Fang Wang, Jia Yu   +23 more
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Involvement of YTHDF1 in renal fibrosis progression via up‐regulating YAP

The FASEB Journal, 2022
Abstract Renal fibrosis is a progressive, fatal renal disease characterized by the aberrant accumulation of myofibroblasts that produce excess extracellular matrix (ECM) in the renal interstitium and glomeruli. Yes‐associated protein (YAP) has been regarded as a crucial modulator in myofibroblast transformation, but its upstream ...
Jia Xing, Yu‐Chen He, Kai‐Yue Wang, Peng‐Zhi Wan, Xiao‐Yue Zhai   +4 more
openaire   +2 more sources

YTHDF1 differentiates the contributing roles of mTORC1 in aging

Molecular Cell
The mechanistic target of rapamycin (mTOR) serves as an essential hub in sensing metabolic stress and regulating aging, although the differential contributions of mTOR-regulated protein and cholesterol synthesis are unclear. Post-transcriptional modifications of mRNAs, such as N6-methyladenosine (m6A), occur rapidly in response to acute environmental ...
Chenzhong, Xu, Cong, Yu, Jie, Zhang, Zhen, Zhang, Jin, Zhang, Yuan, Meng, Ming, Wang, Minting, Wen, Junhao, Chen, Yuping, Ning, Xinchun, Chen, Jinke, Gu, Wen, Su, Baohua, Liu   +13 more
exaly   +3 more sources

YTHDF1 is pivotal for maintenance of cardiac homeostasis

Journal of Molecular and Cellular Cardiology
The YTH-domain family (YTHDF) of RNA binding proteins can control gene expression at the post-transcriptional level by regulating mRNAs with N6-methyladenosine (m6A) modifications. Despite the established importance of m6A in the heart, the cardiac role of specific m6A-binding proteins remains unclear.
Federica Accornero, Volha A Golubeva, Lisa E Dorn   +2 more
exaly   +3 more sources

YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells

Biochemical and Biophysical Research Communications, 2021
N6-methyladenosine (m6A) mRNA modification has been defined as a crucial regulator in various biological processes. Recent studies indicated an essential role of YTHDF1, an m6A reader, in the maintenance of intestinal stem cells (ISCs), while the detailed mechanism remains to be explored.
Dan, Jiang, Jingyu, Hou, Yu, Qian, Yunyi, Gao, Xiangwei, Gao, Saisai, Wei   +5 more
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m6A modification associated with YTHDF1 is involved in Japanese encephalitis virus infection

Veterinary Microbiology, 2023
N6-methyladenosine (m6A), the most common modification in mammalian mRNA and viral RNA, regulates mRNA structure, stability, translation, and nuclear export. The Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus causing severe neurologic disease in humans. To date, the role of m6A modification in JEV infection remains unclear. Herein, we
Xiao-han Li, Jing Chen, Yu-da Ou, Xiang Zhong, Jia-huan Hu, Rui-cong Sun, Ying-jun Lv, Jian-chao Wei, Yun Young Go, Bin Zhou   +9 more
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FMRP phosphorylation modulates neuronal translation through YTHDF1

2022
Abstract Translation activation of local synaptic mRNAs is critical to learning and memory 1 -3 . Despite extensive studies on how phosphorylation of ribosomal proteins and translation factors enables timely response to exogenous stimuli 4,
Zhongyu Zou, Jiangbo Wei, Yantao Chen, Yunhee Kang, Hailing Shi, Fan Yang, Shijie Chen, Ying Zhou, Caraline Sepich-Poore, Xiaoxi Zhuang, Xiaoming Zhou, Hualiang Jiang, Zhexing Wen, Peng Jin, Cheng Luo, Chuan He   +15 more
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Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma

Cancer Biomarkers, 2018
In China, hepatocellular carcinoma (HCC) is the most commonly diagnosed cancer and the leading cause of cancer death in men, followed by lung and stomach cancer. There was an urgent need to identify novel prognostic biomarkers for HCC. We explored the expression pattern of m6A related proteins in HCC tissues by using TCGA in this study.
Xianguang, Zhao, Yang, Chen, Qiqi, Mao, Xiaoyun, Jiang, Weiru, Jiang, Jiajie, Chen, Weijia, Xu, Liang, Zhong, Xu, Sun   +8 more
openaire   +2 more sources

The RNA m6A Reader YTHDF1 Is Required for Acute Myeloid Leukemia Progression

Cancer Research, 2023
Abstract N6-methyladenosine (m6A), the most abundant modification in mRNAs, has been defined as a crucial modulator in the progression of acute myelogenous leukemia (AML). Identification of the key regulators of m6A modifications in AML could provide further insights into AML biology and ...
Yun-Guang Hong, Zhigang Yang, Yan Chen, Tian Liu, Yuyuan Zheng, Chun Zhou, Guo-Cai Wu, Yinhui Chen, Juan Xia, Ruiting Wen, Wenxin Liu, Yi Zhao, Jin Chen, Xiangwei Gao, Zhanghui Chen   +14 more
openaire   +2 more sources