Results 201 to 210 of about 7,941 (215)

Pyrrolidinium Fullerenes as YTHDF1 Inhibitors for Targeted Tumor Therapy

Advanced Healthcare Materials
Abstract Cancer remains a leading cause of global morbidity and mortality, necessitating the development of novel targeted therapies. This study explores the therapeutic potential of pyrrolidinium fullerenes as YTH N 6 ‐methyladenosine RNA binding protein 1 (YTHDF1 ...
Xin Wang, Weixin Zhang, Jiawei Huo, Zehu Wang, Yating Liu, Libin Yang, Shu Zhang, Shiliang Chen, Yuan Xu, Hedong Qi, Jiacheng Sun, Yiwen Pan, Yicheng Lu, Bowen Li, Yijun Wang, Meihan Liu, Jiao Li, Shumu Li, Chong Zhao, Yamin Li, Feng Yu, Zhanfeng Wang, Qingqing Guo, Jie Li, Chunru Wang   +24 more
openaire   +2 more sources

RNA m6A reader YTHDF1 facilitates inflammation via enhancing NLRP3 translation

Biochemical and Biophysical Research Communications, 2022
N6-methyladenosine (m6A) modification of mRNAs is involved in multiple essential biological processes, dynamically regulated by m6A "writers", "erasers", and "readers". Yet, the detailed functional roles of RNA m6A reader proteins, such as YTHDFs, are largely unknown.
Wei-Yuan, Hao, Yan, Lou, Guo-Ying, Hu, Chao-Yi, Qian, Wei-Ren, Liang, Jun, Zhao, Xiao-Hong, Wang   +6 more
exaly   +3 more sources

Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1

Phytomedicine
Curdione, an active sesquiterpene found in Curcumae Rhizoma, exhibits strong anti-inflammatory and antitumor properties, but its mechanism of action against uterine leiomyomas (ULMs) is not yet clear.This study aims to clarify the anti-proliferative effects of curdione on ULMs and explore the molecular mechanisms, with specific focus on the role of the
Xuan Yang, Jiheng Zuo, Tiantian Qiu, Hui Ren, Ruiya Qian, Wenting Luo, Zongshun Chen, Donghua Li   +7 more
openaire   +2 more sources

O-GlcNAc regulates YTHDF1 and YTHDF3 activity

Nature Cell Biology, 2023
Mary W. N. Burns, Jennifer J. Kohler
openaire   +2 more sources

m6A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

Frontiers of Medicine
Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction (MI) can lead to heart failure. RNA N6-methyladenosine (m6A) methylation has been shown to play a pivotal role in the occurrence and development of many illnesses.
Han, Wu, Weitao, Jiang, Ping, Pang, Wei, Si, Xue, Kong, Xinyue, Zhang, Yuting, Xiong, Chunlei, Wang, Feng, Zhang, Jinglun, Song, Yang, Yang, Linghua, Zeng, Kuiwu, Liu, Yingqiong, Jia, Zhuo, Wang, Jiaming, Ju, Hongtao, Diao, Yu, Bian, Baofeng, Yang   +18 more
openaire   +2 more sources

The m6A-Binding Protein YTHDF1 Mediates Immune Evasion

Cancer Discovery, 2019
Abstract Loss of the mRNA m6A-binding protein YTHDF1 in dendritic cells enhances antitumor immunity.
openaire   +1 more source

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation

Cell Proliferation, 2022
Jiong Li, Ke Chen, Honghong Wang
exaly  

The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

Molecular Therapy - Nucleic Acids, 2021
Xiaolin Zhong, Jing Zhong
exaly  

Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis

Journal of Hepatology, 2023
Chi Chun Wong, Jun Yu
exaly  

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation

Journal of Gastroenterology and Hepatology (Australia), 2022
Xiang Huang, Tianhong Su, Ming Kuang
exaly