A facile assay for zDHHC palmitoyl transferase activation elucidates effects of mutation and modification [PDF]
Journal of Lipid ResearchAt least 10% of proteins constituting the human proteome are subject to S-acylation by a long-chain fatty acid, thioesterified to a Cys thiol side chain.
Naoko Adachi +2 more
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A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation. [PDF]
Nat Biotechnol, 2023 The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here
Ocasio CA +15 more
europepmc +7 more sources
Construction and validation of prognostic risk model for hepatocellular carcinoma based on biological analysis of palmitoyl-associated enzyme long-chain non-coding RNA [PDF]
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To explore the effect of screening the expression of long non-coding RNA (lncRNA) related to palmitoylation on prognosis of liver cancer based on The Cancer Genome Atlas (TCGA) database and construct a risk prediction model in liver cancer ...
YU Li +4 more
doaj +3 more sources
Protein S-Palmitoylation as Potential Therapeutic Target for Dermatoses [PDF]
BiomoleculesProtein S-palmitoylation is a pivotal yet poorly integrated research field in dermatology. This reversible post-translational lipid modification primarily occurs on cysteine residues and is principally catalyzed by zinc finger and Asp-His-His-Cys DHHC ...
Yanhai Feng +9 more
doaj +2 more sources
Diverse Roles of Protein Palmitoylation in Cancer Progression, Immunity, Stemness, and Beyond [PDF]
Cells, 2023 Protein S-palmitoylation, a type of post-translational modification, refers to the reversible process of attachment of a fatty acyl chain—a 16-carbon palmitate acid—to the specific cysteine residues on target proteins.
Mingli Li, Leisi Zhang, Chun-Wei Chen
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STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity [PDF]
Advanced Science, 2023 STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis.
Zhichuan Zhu +13 more
doaj +6 more sources
Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression [PDF]
Molecular Therapy: Nucleic Acids, 2022 High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang +6 more
doaj +2 more sources
Recent advances in S-palmitoylation and its emerging roles in human diseases [PDF]
Journal of Hematology & OncologyS-palmitoylation, one reversible post-translational modification (PTM) involving the binding of palmitate to proteins, influences protein stability, localization and interactions.
Juanjuan Shang +2 more
doaj +2 more sources
S-acylation dependent post-translational cross-talk regulates large conductance calcium- and voltage- activated potassium (BK) channels [PDF]
Frontiers in Physiology, 2014 Mechanisms that control surface expression and/or activity of large conductance calcium-activated potassium (BK) channels are important determinants of their (patho)physiological function.
Michael J Shipston
doaj +5 more sources
Role of S-palmitoylation in digestive system diseases [PDF]
Cell Death DiscoveryDigestive system diseases, including liver diseases, gastrointestinal cancers, and inflammatory bowel diseases, pose major health challenges worldwide.
Hanqing Li +4 more
doaj +2 more sources