Results 11 to 20 of about 490 (156)

Research progress on S-palmitoylation modification mediated by the ZDHHC family in glioblastoma. [PDF]

Front Cell Dev Biol
S-Palmitoylation has been widely noticed and studied in a variety of diseases. Increasing evidence suggests that S-palmitoylation modification also plays a key role in Glioblastoma (GBM).
Tang B, Kang W, Dong Q, Qin Z, Duan L, Zhao X, Yuan G, Pan Y.   +7 more
europepmc   +6 more sources

Substrate recruitment by zDHHC protein acyltransferases [PDF]

Open Biology, 2021
Protein palmitoylation is the post-translational attachment of fatty acids, most commonly palmitate (C16 : 0), onto a cysteine residue of a protein. This reaction is catalysed by a family of integral membrane proteins, the zDHHC protein acyltransferases (
Martin Ian P. Malgapo, Maurine E. Linder
doaj   +3 more sources

The zDHHC family of S-acyltransferases [PDF]

Biochemical Society Transactions, 2015
The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes
Chamberlain, Luke H., Diez Ardanuy, Cinta, Greaves, Jennifer, Lemonidis, Kimon, Salaun, Christine, Sanchez Perez, Maria C., Thomson, David M., Werno, Martin W.   +7 more
core   +5 more sources

Substrate selectivity in the zDHHC family of S-acyltransferases [PDF]

Biochemical Society Transactions, 2017
S-acylation is a reversible lipid modification occurring on cysteine residues mediated by a family of membrane-bound 'zDHHC' enzymes. S-acylation predominantly results in anchoring of soluble proteins to membrane compartments or in the trafficking of ...
Chamberlain, Luke H., Diez-Ardanuy, Cinta, Greaves, Jennifer, Kouskou, Marianna, Lemonidis, Kimon, Salaun, Christine   +5 more
core   +5 more sources

ZDHHC9 and spermine metabolism: a palmitoylation-driven pathway to prostate carcinogenesis [PDF]

Journal of Translational Medicine
Background Spermine is a natural metabolite that has been shown to hinder the progression of prostate cancer. Protein palmitoylation, a recently identified post-translational lipid modification, is catalyzed by a family of 23 enzymes known as zinc finger
Chunli Chen, Yiqun Zhang, Gaofa Wang, Yang Liu, Bin Ye, Shengqiang Zhou, Kelong Wang, Haojie Zheng, Xiaoxia Dong, Chao Luo, Junshuo Zhou, Kangkang Zeng, Caiyun Fang, Li Shen   +13 more
doaj   +2 more sources

Bioinformatics Analysis of the Prognostic and Biological Significance of ZDHHC-Protein Acyltransferases in Kidney Renal Clear Cell Carcinoma [PDF]

Frontiers in Oncology, 2020
ZDHHC-protein acyltransferases (ZDHHCs) are a family of 23 signature Asp-His-His-Cys (DHHC) domain-containing enzymes that mediate palmitoylation by covalent attachment of the 16-carbon fatty acid palmitate to thiol groups of specific cysteine residues ...
Zhuang Liu, Chang Liu, Mingming Xiao, Yamei Han, Siyue Zhang, Bo Xu, Bo Xu   +6 more
doaj   +3 more sources

Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A
Protein post-translational modifications (PTM) play a crucial role in the modulation of synaptic function and their alterations are involved in the onset and progression of neurodegenerative disorders.
Natale F, Spinelli M, Rinaudo M, Gulisano W, Nifo Sarrapochiello I, Aceto G, Puzzo D, Fusco S, Grassi C.   +8 more
europepmc   +3 more sources

RETRACTED ARTICLE: Palmitoyl transferases act as novel drug targets for pancreatic cancer

Journal of Translational Medicine, 2023
Background Pancreatic adenocarcinoma (PAAD) is one of the most leading causes of cancer-related death across the world with the limited efficiency and response rate of immunotherapy.
Zhiqing Lin, Ziru Lv, Xin Liu, Keke Huang   +3 more
doaj   +2 more sources

Comprehensive analysis of key palmitoylation-modifying enzymes in clear cell renal cell carcinoma: implications for prognosis and therapy [PDF]

Cancer Cell International
Background Palmitoylation, a key post-translational modification, plays a crucial role in tumor progression, yet its landscape in clear cell renal cell carcinoma (ccRCC) remains poorly characterized.
Guandu Li, Yiduo Zhuge, Xinrui Xu, Jianhua Wang, Zunwen Zheng, Xiangyu Che, Xu Zheng, Xiaochen Qi, Guangzhen Wu   +8 more
doaj   +2 more sources

Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release. [PDF]

Proc Natl Acad Sci U S A
Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the
Liu Z, Li S, Wang C, Vidmar KJ, Bracey S, Li L, Willard B, Miyagi M, Lan T, Dickinson BC, Osme A, Pizarro TT, Xiao TS.   +12 more
europepmc   +3 more sources