Results 21 to 30 of about 490 (156)

The role of s-palmitoylation in neurological diseases: implication for zDHHC family. [PDF]

Front Pharmacol, 2023
S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain.
Liao D, Huang Y, Liu D, Zhang H, Shi X, Li X, Luo P.   +6 more
europepmc   +4 more sources

zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective. [PDF]

Int J Mol Sci
S-acylation, which includes S-palmitoylation, is the only known reversible lipid-based post-translational protein modification. S-palmitoylation is mediated by palmitoyl acyltransferases (PATs), a family of 23 enzymes commonly referred to as zDHHCs, which catalyze the addition of palmitate to cysteine residues on specific target proteins.
Abdulrahman FA, Benford KA, Lin GT, Maroun AJ, Sammons C, Shirzad DN, Tsai H, Van Brunt VL, Jones Z, Marquez JE, Ratkus EC, Shehadeh AK, Abasto Valle H, Fejzo D, Gilbert AE, McWee CA, Underwood LF, Indico E, Rork BB, Nanjundan M.   +19 more
europepmc   +3 more sources

ZDHHC2-Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation. [PDF]

Adv Sci (Weinh)
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shao S, Li W, Hong Y, Zeng R, Zhu L, Yi L, Li Y, Wang Y, Huang H, Jiang X, Jin X.   +10 more
europepmc   +2 more sources

Regulatory effects of post-translational modifications on zDHHC S-acyltransferases [PDF]

Journal of Biological Chemistry, 2020
The human zDHHC S-acyltransferase family comprises 23 enzymes that mediate the S-acylation of a multitude of cellular proteins, including channels, receptors, transporters, signaling molecules, scaffolds, and chaperones. This reversible post-transitional modification (PTM) involves the attachment of a fatty acyl chain, usually derived from palmitoyl ...
Filip Zmuda, Luke H. Chamberlain
openaire   +4 more sources

NS1‐mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells [PDF]

, 2021
Influenza A viruses contain two S-acylated proteins, the ion channel M2 and the glycoprotein hemagglutinin (HA). Acylation of the latter is essential for virus replication.
Freund, Christian, Gadalla, Mohamed Rasheed, Han, Xueijiao, Kordyukova, Larisa, Morrison, Eliot, Serebryakova, Marina V., Veit, Michael, Wolff, Thorsten   +7 more
core   +2 more sources

Accessory proteins of the zDHHC family of S-acylation enzymes [PDF]

Journal of Cell Science, 2020
ABSTRACT Almost two decades have passed since seminal work in Saccharomyces cerevisiae identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases. These enzymes are ubiquitous in the eukarya domain, with 23 distinct zDHHC-encoding genes in the human genome.
Christine Salaun, Carolina Locatelli, Filip Zmuda, Juan Cabrera González, Luke H. Chamberlain   +4 more
openaire   +4 more sources

Dysfunctional Decidual CD4⁺T Cells Induce Recurrent Pregnancy Loss via Palmitoylation-Dependent Tim-3 Lysosomal Sorting and Degradation. [PDF]

Adv Sci (Weinh)
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Cui L, Meng X, Luo Y, Qian J, Sun F, Qiu M, Wang S.   +6 more
europepmc   +2 more sources

Post-translational palmitoylation of metabolic proteins [PDF]

, 2023
Numerous cellular proteins are post-translationally modified by addition of a lipid group to their structure, which dynamically influences the proteome by increasing hydrophobicity of proteins often impacting protein conformation, localization, stability,
Dennis, Kaitlyn, Heather, Lisa C
core   +2 more sources

ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma

BMC Cancer, 2023
Background Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
Zhen-Yuan Liu, Tian Lan, Feng Tang, Yong-Ze He, Jin-Sheng Liu, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li   +8 more
doaj   +1 more source

Cytoplasmic tail determines the membrane trafficking and localization of SARS-CoV-2 spike protein

Frontiers in Molecular Biosciences, 2022
The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry through associating with ACE2 on host cells. Intracellular trafficking and palmitoylation of S protein are required for its function.
Qinlin Li, Qinlin Li, Qinlin Li, Yihan Liu, Yihan Liu, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +7 more
doaj   +1 more source