Results 51 to 60 of about 490 (156)

Editorial: Protein lipidation in health and disease [PDF]

, 2023
No abstract ...
Fuller, William, Mejías, Rebeca
core   +1 more source

A fluorescence-based assay to monitor autopalmitoylation of zDHHC proteins applicable to high-throughput screening [PDF]

Analytical Biochemistry, 2014
Palmitoylation, the posttranslational thioester-linked modification of a 16-carbon saturated fatty acid onto the cysteine residue of a protein, has garnered considerable attention due to its implication in a multitude of disease states. The signature DHHC motif (Asp-His-His-Cys) identifies a family of protein acyltransferases (PATs) that catalyze the S-
Laura D, Hamel, Robert J, Deschenes, David A, Mitchell   +2 more
openaire   +2 more sources

Deconvoluting the biology and druggability of protein lipidation using chemical proteomics [PDF]

, 2020
Lipids are indispensable cellular building blocks, and their post-translational attachment to proteins makes them important regulators of many biological processes. Dysfunction of protein lipidation is also implicated in many pathological states, yet its
Hassan, S, Losada de la Lastra, A, Tate, EW   +2 more
core   +1 more source

S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19 [PDF]

, 2018
STX19 is an unusual Qa-SNARE as it lacks a C-terminal transmembrane domain. However, it is efficiently targeted to post-Golgi membranes. We have set out to determine the intracellular localisation of endogenous STX19 and elucidate the mechanism by which ...
Akimzhanov, Blanc, Bock, Boeing, Breusegem, Chamberlain, Cheeseman, Collins, Cox, Crooks, D'Orlando, Duncan, Fukasawa, Fukata, Gordon, Gordon, Greaves, Greaves, Greaves, Greaves, Grigoriev, Hellewell, Jahn, Jones, Kang, Kloepper, Kozik, Lee, Lin, Linder, Lu, Martin, Martin, Matsuda, Meijering, Melkonian, Misaki, Muszbek, Ohno, Ohno, Page, Peränen, Prekeris, Rahajeng, Resh, Robinson, Robinson, Rothbauer, Salaün, Schmick, Schneider, Sharma, Simpson, Smotrys, Tomatis, Vidal-Quadras, Wang, Wen, Yang, Yap, Yokoi, zur Stadt   +61 more
core   +4 more sources

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation

PLOS ONE
Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral membrane proteins.
Mingjie Bai, Emily Gallen, Sarah Memarzadeh, Jacqueline Howie, Xing Gao, Chien-Wen S. Kuo, Elaine Brown, Simon Swingler, Sam J. Wilson, Michael J. Shattock, David J. France, William Fuller   +11 more
openaire   +3 more sources

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a. [PDF]

, 2017
High-fat diet (HFD) and metabolic diseases cause detrimental effects on hippocampal synaptic plasticity, learning, and memory through molecular mechanisms still poorly understood.
D\u2019Ascenzo, M (ORCID:0000-0003-0073-412X), Fusco, S (ORCID:0000-0003-3294-0016), Grassi, A, Grassi, C. (ORCID:0000-0001-7253-1685), Lapenta, R, Li Puma, Domenica Donatella (ORCID:0000-0001-6729-6967), Mainardi, M, Mattera, A, Natale, F (ORCID:0000-0001-7856-930X), Rinaudo, M (ORCID:0000-0002-6130-7335), Ripoli, C (ORCID:0000-0002-5315-0163), Scala, F, Spinelli, M   +12 more
core   +1 more source

Aberrant Protein S‐Palmitoylation: A Novel Therapeutic Target in Alzheimer's Disease

Alzheimer's &Dementia, Volume 21, Issue S1, December 2025.
Abstract Background Protein post‐translational modifications are critical regulators of synaptic function, and their disruption is implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease (AD). Among these modifications, S‐palmitoylation, catalyzed by zinc finger DHHC domain‐containing (zDHHC) S‐acyltransferases, has ...
Claudio Grassi, Francesca Natale, Matteo Spinelli, Marco Rinaudo, Ida Nifo Sarrapochiello, Giuseppe Aceto, Daniela Puzzo, Salvatore Fusco   +7 more
wiley   +1 more source