Results 241 to 250 of about 9,464 (261)

The chemistry of PET imaging with zirconium-89

Chemical Society Reviews, 2018
This review describes the coordination chemistry that underpins PET imaging with zirconium-89 and discusses the biological data obtainable from the radiolabelled complexes.
Jonathan R. Dilworth, Sofia I. Pascu
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Modeling and experimental data of zirconium-89 production yield

Applied Radiation and Isotopes, 2017
The radionuclide zirconium-89 can be employed for the positron emission tomography (PET). In this study 89Zr excitation function via 89Y(p,n)89Zr reaction was calculated by the TALYS-1.8 code based on microscopic level density model. The formation of 89Zr was simulated using the Monte Carlo simulation code MCNPX to calculate the integral yield in the ...
Mozhgan, Sharifian, Mahdi, Sadeghi, Behrouz, Alirezapour, Mohammad, Yarmohammadi, Khosro, Ardaneh   +4 more
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Accelerator production of the positron emitter zirconium-89

Annals of Nuclear Energy, 2012
We here presented a method for zirconium-89 production using a low-energy cyclotron. The half-life of 89Zr (T1/2 = 78.4 h) is suitable for immunoPET. 89Zr was produced via the 89Y(p, n)89Zr nuclear process at 20 μA current and 15 → 5 MeV protons beam (20 min). Yield of about 60.77 MBq 89Zr per μAh was experimentally obtained. Also, excitation functions
Mahdi Sadeghi, Milad Enferadi, Mahdi Bakhtiari   +2 more
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The Radiopharmaceutical Chemistry of Zirconium-89

2019
Over the past decade, the increasing availability of zirconium-89 has fueled a rise in the development and use of targeted positron emission tomography (PET) probes with relatively long serum half-lives, particularly radiolabeled antibodies. The stable coordination of 89Zr in radiopharmaceuticals is of critical importance to prevent its in vivo release
Bernadette V. Marquez-Nostra, Nerissa Viola   +1 more
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Production, applications and status of zirconium-89 immunoPET agents

Journal of Radioanalytical and Nuclear Chemistry, 2017
Zirconium-89 has attracted huge interests and is used in tracing and quantification of slow biological processes and labeling of long half-live biomolecules such as monoclonal antibodies for pharmacokinetic studies and clinical trials. In this review, a concise introduction to targetry, irradiation data, separation and coordination chemistry of ...
Amir R. Jalilian, Joao Alberto Osso
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Turn-over of Carrier-free Zirconium-89 in Man

Nature, 1957
IN the course of a survey of positron-emitting radioactive isotopes for potential use in external localization of human brain tumours1, zirconium-89 (half-life, 79 hr.) was studied. Positrons with a maximum energy of about 0.9 MeV. and gamma rays of 0.9 MeV. energy are emitted.
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Two bifunctional desferrioxamine chelators for bioorthogonal labeling of biovectors with zirconium-89

Organic & Biomolecular Chemistry, 2018
We report two bifunctional chelators, DFO-Cys and DFO-CBT, to label biovectors with zirconium-89 according to the 2-cyanobenzothiazole/1,2-aminothiol cycloaddition.
F. Gao, C. Ieritano, K.-T. Chen, G. M. Dias, J. Rousseau, F. Bénard, Y. Seimbille   +6 more
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Highlighting New Research Trends on Zirconium-89 Radiopharmaceuticals Beyond Antibodies

Seminars in Nuclear Medicine
Zirconium-89 (89Zr) is a cyclotron-produced positron-emitting radioisotope with a half-life of 3.27 days, which makes delayed or longitudinal imaging possible. It is a superior isotope for tracking particles over several days at a high sensitivity, resolution, and specificity.
Janie Duvenhage, Maryke Kahts, Beverley Summers, Jan Rijn Zeevaart, Thomas Ebenhan   +4 more
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A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

Chemical Communications, 2016
A squaramide ester derivative of desferrioxamine B is used to attach zirconium-89 to the antibody trastuzumab and the new conjugate is used for positron emission tomography imaging in mouse models of breast cancer.
Stacey E, Rudd, Peter, Roselt, Carleen, Cullinane, Rodney J, Hicks, Paul S, Donnelly   +4 more
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Light‐Driven Radiochemistry with Fluorine‐18, Carbon‐11 and Zirconium‐89

Angewandte Chemie International Edition
AbstractThis review discusses recent advances in light‐driven radiochemistry for three key isotopes: fluorine‐18, carbon‐11, and zirconium‐89, and their applications in positron emission tomography (PET). In the case of fluorine‐18, the predominant approach involves the use of cyclotron‐produced [18F]fluoride or reagents derived thereof.
Daniel Lin, Laura M. Lechermann, Malcolm P. Huestis, Jan Marik, Jeroen B. I. Sap   +4 more
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