Дизајн на физибилити студија за воспоставување на производство на zirconium-89 радиоизотоп и имплементација на 89Zr-радиофармацевтици во клиничката пракса во Република Северна Македонија [PDF]
, 2023 In the last decade, the application of radiopharmaceuticals based on zirconium-89 (89Zr) radiometal has increased in both preclinical and clinical studies.
Angelovska, Bistra +8 more
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EJNMMI Research, 2020 Purpose Tracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t 1/2 = 78.4 h) has recently been used to synthesize [89Zr]Zr(oxinate)4 for cell
Laura M. Lechermann +13 more
doaj +1 more source
89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors [PDF]
, 2012 The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20-30% of breast cancers and is associated with tumor growth, angiogenesis, and development of distant metastases.
Chang, Albert J. +5 more
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Human Absorbed Dose Estimation of 89Zr-Anti-HER2 Complex Based on Animal Data [PDF]
Iranian Journal of Medical PhysicsIntroduction: This study aimed to estimate the radiation absorbed dose of human organs after injection of a high-potential PET radioimmunoconjugate of HER2+ breast cancers using the medical internal radiation dose (MIRD) method and the radiation dose ...
Hassan Yousefnia +2 more
doaj +1 more source
Molecules, 2020 Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous system. Due to the lack of effective treatment options, the prognosis for patients remains bleak.
Darpan N. Pandya +6 more
doaj +1 more source
PET Imaging of Acidic Tumor Environment With 89Zr-labeled pHLIP Probes
Frontiers in Oncology, 2022 Acidosis of the tumor microenvironment is a hallmark of tumor progression and has emerged as an essential biomarker for cancer diagnosis, prognosis, and evaluation of treatment response.
David Bauer +10 more
doaj +1 more source
InstrumentsZirconium-89 (89Zr) is a widely used radionuclide in immune-PET imaging due to its physical decay characteristics. Despite its importance, the production of 89Zr radiopharmaceuticals remains largely manual, with limited cost-effective automation ...
Abdulaziz Yahya M. Hussain +11 more
doaj +1 more source
Application of Immuno-PET in Antibody–Drug Conjugate Development
Molecular Imaging, 2018 Targeted therapies hold great promise for cancer treatment and may exhibit even greater efficacy when combined with patient selection tools. The clinical impact of identifying likely responders includes reducing the number of unnecessary and ineffective ...
Kendra S. Carmon PhD, Ali Azhdarinia PhD
doaj +1 more source
Cyclotron production of high–specific activity 55Co and in vivo evaluation of the stability of 55Co metal-chelate-peptide complexes [PDF]
, 2015 This work describes the production of high–specific activity 55 Co and the evaluation of the stability of 55 Co-metal-chelate-peptide complexes in vivo. 55 Co was produced via the 58 Ni(p,α) 55 Co reaction and purified using anion exchange chromatography
Bollinger, Elizabeth +6 more
core +3 more sources
Why are we failing to implement imaging studies with radiolabelled new molecular entities in early oncology drug development? [PDF]
, 2014 In early drug development advanced imaging techniques can help with progressing new molecular entities (NME) to subsequent phases of drug development and thus reduce attrition.
Lahn, M +3 more
core +3 more sources