Results 31 to 40 of about 9,464 (261)

89Zr-leukocyte labelling for cell trafficking: in vitro and preclinical investigations

EJNMMI Radiopharmacy and Chemistry, 2023
Background The non-invasive imaging of leukocyte trafficking to assess inflammatory areas and monitor immunotherapy is currently generating great interest. There is a need to develop more robust cell labelling and imaging approaches to track living cells.
Maryke Kahts, Hua Guo, Harikrishna Kommidi, Yanping Yang, Haluk Burcak Sayman, Beverley Summers, Richard Ting, Jan Rijn Zeevaart, Mike Sathekge, Omer Aras   +9 more
doaj   +1 more source

Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques [PDF]

, 2013
Author Manuscript 2013 March 02.Rationale: Myeloid cell content in atherosclerotic plaques associates with rupture and thrombosis. Thus, imaging of lesional monocytes and macrophages could serve as a biomarker of disease progression and therapeutic ...
Anderson, Daniel Griffith, Borodovsky, Anna, Di Carli, M. F., Dutta, P., Fitzgerald, K., Iwamoto, Y., Keliher, Edmund J., Libby, Peter, Majmudar, Maulik D., Nahrendorf, Matthias, Sena, B., Swirski, F. K., Truelove, J. J., Weissleder, R., Yoo, J.   +14 more
core   +1 more source

Scaling-down antibody radiolabeling reactions with zirconium-89

Dalton Transactions, 2016
A 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale has been reported.
James C. Knight, Stephen J. Paisey, Adam M. Dabkowski, Cristina Marculescu, Anwen S. Williams, Christopher Marshall, Bart Cornelissen   +6 more
openaire   +3 more sources

Role of noninvasive molecular imaging in determining response [PDF]

, 2018
The intersection of immunotherapy and radiation oncology is a rapidly evolving area of preclinical and clinical investigation. The strategy of combining radiation and immunotherapy to enhance local and systemic antitumor immune responses is intriguing ...
Marciscano, Ariel E, Thorek, Daniel L.J.
core   +2 more sources

Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model

EJNMMI Research, 2018
Background Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury.
Kingsley O. Asiedu, Munira Ferdousi, Phuongnga T. Ton, Stephen S. Adler, Peter L. Choyke, Noriko Sato   +5 more
doaj   +1 more source

From Bench to Bedside: Patient-Oriented Radiopharmaceutical Development in Nuclear Medicine Based on the Example of [⁸⁹Zr]Zr-PSMA-DFO

Molecules, 2023
The interdisciplinary possibilities inherent in nuclear medicine offer an opportunity for the patient-centered development of radioactive pharmaceuticals based on specific research questions.
Klaus Schomäcker, Felix Dietlein, Sergio Muñoz Vázquez, Feodor Braun, Thomas Fischer, Philipp Krapf, Alexander Drzezga, Markus Dietlein   +7 more
doaj   +1 more source

Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Molecules, 2021
Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years.
Xu Zhou, Linlin Dong, Langtao Shen
doaj   +1 more source

Di-macrocyclic terephthalamide ligands as chelators for the PET radionuclide zirconium-89. [PDF]

Chem Commun (Camb), 2015
Octadentate terephthalamide ligands can be easily radiolabeled with 89Zr and are highly stable in vitro. They represent a novel class of bifunctional chelators for 89Zr.
Pandya DN, Pailloux S, Tatum D, Magda D, Wadas TJ.   +4 more
europepmc   +4 more sources

Immunoscintigraphy for therapy decision making and follow-up of biological therapies [PDF]

, 2016
With the availability of new biological therapies there is the need of more accurate diagnostic tools to noninvasively assess the presence of their targets.
Auletta, S., Carideo, Luciano, Galli, Filippo, Lauri, Chiara, Pacilio, Massimiliano, Signore, Alberto, Valabrega, Stefano   +6 more
core   +2 more sources

Standardized methods for the production of high specific-activity zirconium-89 [PDF]

Nuclear Medicine and Biology, 2009
Zirconium-89 is an attractive metallo-radionuclide for use in immuno-PET due to favorable decay characteristics. Standardized methods for the routine production and isolation of high-purity and high-specific-activity (89)Zr using a small cyclotron are reported.
Jason P, Holland, Yiauchung, Sheh, Jason S, Lewis   +2 more
openaire   +2 more sources