Evaluation of macrocyclic hydroxyisophthalamide ligands as chelators for zirconium-89. [PDF]
PLoS ONE, 2017 The development of bifunctional chelators (BFCs) for zirconium-89 immuno-PET applications is an area of active research. Herein we report the synthesis and evaluation of octadentate hydroxyisophthalamide ligands (1 and 2) as zirconium-89 chelators. While
Nikunj B Bhatt +5 more
doaj +5 more sources
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Positron emission tomography (PET) is a highly sensitive method that provides fine resolution images, useful in the field of clinical diagnostics.
Valentina Albanese +11 more
doaj +6 more sources
Promising Performance of 4HMS, a New Zirconium-89 Octadendate Chelator [PDF]
ACS Omega, 2020 Over the last decade, the interest in zirconium-89 (89Zr) as a positron-emitting radionuclide increased considerably because of its standardized production and its physical half-life (78.41 h), which matches the biological half-life of antibodies and its successful use in preclinical and clinical applications.
Aiman H. Alnahwi +4 more
doaj +5 more sources
Optimization of cyclotron production for radiometal of Zirconium 89 [PDF]
Acta Physica Polonica A, 2015 Zirconium 89 (89Zr) is a promising radionuclide for development of new PET agents due to its convenient half life of 78.4 h, β+ emission rate of 23%, low maximum energy of 0.9 MeV resulting in good spatial resolution, a stable daughter isotope of yttrium-
Dabkowski, Adam M. +3 more
core +4 more sources
Phantom-based investigation of block sequential regularised expectation maximisation (BSREM) reconstruction for zirconium-89 PET-CT for varied count levels [PDF]
EJNMMI PhysicsBackground Zirconium-89 (Zr-89) PET tracers have become increasingly significant in the field of nuclear medicine due to their 3-day physical half-life, allowing for the study of dynamic biological processes over relatively long timeframes. To date there
Lara M. Bonney +2 more
doaj +2 more sources
Zirconium 89 and Copper 64 for ImmunoPET: From Antibody Bioconjugation and Radiolabeling to Molecular Imaging [PDF]
PharmaceuticsImmunotherapy has transformed cancer treatment. Nevertheless, given the heterogeneity of clinical efficacy, the multiplicity of treatment options available and the possibility of serious adverse effects, selecting the most effective treatment has become ...
Laure Badier, Isabelle Quelven
doaj +2 more sources
The Race for Hydroxamate-Based Zirconium-89 Chelators. [PDF]
Cancers (Basel), 2021 Metallic radionuclides conjugated to biological vectors via an appropriate chelator are employed in nuclear medicine for the diagnosis (imaging) and radiotherapy of diseases. For the application of radiolabeled antibodies using positron emission tomography (immunoPET), zirconium-89 has gained increasing interest over the last decades as its physical ...
Feiner IVJ +6 more
europepmc +10 more sources
Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89 [PDF]
Biomolecules, 2019 Fusarinine C (FSC) has recently been shown to be a promising and novel chelator for 89Zr. Here, FSC has been further derivatized to optimize the complexation properties of FSC-based chelators for 89Zr-labeling by introducing additional carboxylic groups.
Chuangyan Zhai +11 more
doaj +2 more sources
Synthesis and preclinical development of a novel 68Ga/89Zr-Labelled ανβ6-integrin targeting trimer [PDF]
EJNMMI Radiopharmacy and ChemistryBackground The αvβ6 integrin has emerged as a valuable target for theranostic applications in nuclear medicine with high applicability across a variety of cancers, including head-and-neck, lung, breast, and pancreatic carcinomas. [⁶⁸Ga]Ga-Trivehexin is a
Giacomo Gariglio +7 more
doaj +2 more sources
Zirconium-89 Complexes for Cell Tracking with Positron Emission Tomography [PDF]
, 2015 Tracking cell migration in vivo by scintigraphy using cells labelled with gamma-emitting radionuclides (especially indium-111) is a well-established clinical and research tool.
Ferris, Trevor John
core +1 more source