Results 21 to 30 of about 9,464 (261)
Zirconium-89 labelled rituximab PET-CT imaging of Graves' orbitopathy. [PDF]
Eur J Nucl Med Mol Imaging, 2020 de Keizer B, Laban KG, Kalmann R.
europepmc +5 more sources
A High-Denticity Chelator Based on Desferrioxamine for Enhanced Coordination of Zirconium-89. [PDF]
Inorg Chem, 2020 Herein we report a new high-denticity chelator based on the iron siderophore desferrioxamine (DFO). Our new chelator-DFO2-is acyclic and was designed and synthesized with the purpose of improving the coordination chemistry and radiolabeling performance with radioactive zirconium-89.
Sarbisheh EK +4 more
europepmc +4 more sources
PET tracers based on Zirconium-89. [PDF]
Curr Radiopharm, 2011 Positron emission tomography (PET) imaging with radiolabeled monoclonal antibodies has always been a dynamic area in molecular imaging. With decay half-life (3.3 d) well matched to the circulation half-lives of antibodies (usually on the order of days), (89)Zr has been extensively studied over the last decade.
Zhang Y, Hong H, Cai W.
europepmc +4 more sources
Molecules, 2020 The increased interest in 89Zr-labelled immunoPET imaging probes for use in preclinical and clinical studies has led to a rising demand for the isotope. The highly penetrating 511 and 909 keV photons emitted by 89Zr deliver an undesirably high radiation ...
Vijay Gaja +3 more
doaj +1 more source
Frontiers in Medicine, 2022 Anti-PDL1 is a monoclonal antibody targeting the programmed death-cell ligand (PD-L1) by blocking the programmed death-cell (PD-1)/PD-L1 axis. It restores the immune system response in several tumours, such as non-small cell lung cancer (NSCLC).
Anis Krache +14 more
doaj +1 more source
Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89. [PDF]
Chem Commun (Camb), 2017 The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO).
Allott L +6 more
europepmc +5 more sources
A Semi Rigid Novel Hydroxamate AMPED-Based Ligand for 89Zr PET Imaging
Molecules, 2021 In this work, we designed, developed, characterized, and investigated a new chelator and its bifunctional derivative for 89Zr labeling and PET-imaging. In a preliminary study, we synthesized two hexadentate chelators named AAZTHAS and AAZTHAG, based on ...
Lisa Russelli +6 more
doaj +1 more source
Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data. [PDF]
, 2020 Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours.
Abler, Daniel +13 more
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Cerebral rituximab uptake in multiple sclerosis: A (89)Zr-immunoPET pilot study [PDF]
, 2017 Previous studies have demonstrated that the chimeric monoclonal antibody rituximab significantly reduces clinical and radiological disease activity in relapsing-remitting multiple sclerosis as early as 4 weeks after the first administration.
Barkhof, F +6 more
core +1 more source
Radiolabeling human peripheral blood stem cells for positron emission tomography (PET) imaging in young rhesus monkeys. [PDF]
, 2013 These studies focused on a new radiolabeling technique with copper ((64)Cu) and zirconium ((89)Zr) for positron emission tomography (PET) imaging using a CD45 antibody.
Cherry, Simon R +3 more
core +2 more sources