Results 1 to 10 of about 57,672 (131)

Polyubiquitination and SUMOylation Sites Regulate the Stability of ZO-2 Protein and the Sealing of Tight Junctions [PDF]

Cells, 2022
Tight junctions (TJs) regulate the transit of ions and molecules through the paracellular pathway in epithelial cells. Zonula occludens 2 (ZO-2) is a cytoplasmic TJ protein.
Misael Cano-Cortina, Lourdes Alarcón, Jael Miranda, Otmar Huber, Lorenza González-Mariscal   +4 more
doaj   +4 more sources

Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice [PDF]

Cell Structure and Function
The liver is a complex organ with a highly organized structure in which tight junctions (TJs) play an important role in maintaining their function by regulating barrier properties and cellular polarity.
Masahiko Itoh, Kenji Watanabe, Yoichi Mizukami, Hiroyuki Sugimoto   +3 more
doaj   +4 more sources

Rotenone inhibited osteosarcoma metastasis by modulating ZO-2 expression and location via the ROS/Ca2+/AMPK pathway [PDF]

Redox Report
Background Pulmonary metastases in osteosarcoma (OS) are associated with a poor prognosis. Rotenone has shown anti-cancer activity. However, its effects on metastasis and the underlying mechanisms remain unknown. This study investigated the potential use
Xiang Ma, Zhen Li, Hengwei Ma, Kun Jiang, Bao Chen, Weiquan Wang, Ziqiang Zhu, Jianqiang Wang, Zuozhang Yang, Wang Yunqing, Suwei Dong   +10 more
doaj   +4 more sources

ZO-2 seals the deal for platelet tight junctions [PDF]

Research and Practice in Thrombosis and Haemostasis
Yiheng Zhang, Owen J.T. McCarty, Joseph E. Aslan   +2 more
doaj   +3 more sources

p120 RasGAP and ZO-2 are essential for Hippo signaling and tumor-suppressor function mediated by p190A RhoGAP [PDF]

Cell Reports, 2023
Summary: ARHGAP35, which encodes p190A RhoGAP (p190A), is a major cancer gene. p190A is a tumor suppressor that activates the Hippo pathway. p190A was originally cloned via direct binding to p120 RasGAP (RasGAP).
Hanyue Ouyang, Shuang Wu, Wangji Li, Michael J. Grey, Wenchao Wu, Steen H. Hansen   +5 more
doaj   +2 more sources

Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD. [PDF]

Mol Biol Cell, 2021
ZO-2 interaction with TEAD regulates TEAD movement in and out of the nucleus. nPKCδ blocks formation of ZO-2/TEAD complex. PKA blocks ZO-2 nuclear import. nPKCε activates a NES of ZO-2 and TEAD exportation in a complex with ZO-2 or alone.
Gallego-Gutiérrez H, González-González L, Ramírez-Martínez L, López-Bayghen E, González-Mariscal L.   +4 more
europepmc   +4 more sources

ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration [PDF]

iScience
Summary: Tight junction protein-1 and -2 (Tjp1/ZO-1 and Tjp2/ZO-2) function as scaffold proteins within the tight junction complexes of the blood-retinal barrier (BRB). Although the breakdown of the BRB is implicated in retinopathies, the contribution of
Safiah Mohamed Ali, Bhav Harshad Parikh, Queenie Shu Woon Tan, Barbara Hübner, Aleksandra N. Kozyrina, Animesh Banerjee, Jie Zhao, Debbie Goh, Hanumakumar Bogireddi, Sia Wey Yeo, Daniel Soo Lin Wong, Jianliang Xu, Kim Chi Tran, Zengping Liu, Yun-Zheng Le, Veluchamy Amutha Barathi, Kang Hao Cheong, Jacopo Di Russo, Alexander Ludwig, Walter Hunziker, Xinyi Su   +20 more
doaj   +2 more sources

SUMOylation regulates the intracellular fate of ZO-2. [PDF]

Cell Mol Life Sci, 2017
The zonula occludens (ZO)-2 protein links tight junctional transmembrane proteins to the actin cytoskeleton and associates with splicing and transcription factors in the nucleus. Multiple posttranslational modifications control the intracellular distribution of ZO-2.
Wetzel F, Mittag S, Cano-Cortina M, Wagner T, Krämer OH, Niedenthal R, Gonzalez-Mariscal L, Huber O.   +7 more
europepmc   +3 more sources

Contact and communication: ZO-2 and the Hippo pathway. [PDF]

FEBS J
The PDZ domain‐containing protein ZO‐2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the
Thomas M.
europepmc   +3 more sources

ZO-2 Is a Master Regulator of Gene Expression, Cell Proliferation, Cytoarchitecture, and Cell Size. [PDF]

Int J Mol Sci, 2019
ZO-2 is a cytoplasmic protein of tight junctions (TJs). Here, we describe ZO-2 involvement in the formation of the apical junctional complex during early development and in TJ biogenesis in epithelial cultured cells. ZO-2 acts as a scaffold for the polymerization of claudins at TJs and plays a unique role in the blood–testis barrier, as well as at TJs ...
González-Mariscal L, Gallego-Gutiérrez H, González-González L, Hernández-Guzmán C.   +3 more
europepmc   +4 more sources