PARP‑1 may be involved in hydroquinone‑induced apoptosis by poly ADP‑ribosylation of ZO‑2. [PDF]
Mol Med Rep, 2017 Hydroquinone (HQ), a major reactive metabolite of benzene, contributes to benzene‑induced leukemia. The molecular mechanisms that underlie this activity remain to be elucidated. Poly ADP‑ribosylation (PARylation) is a type of reversible posttranslational modification that is performed by enzymes in the PAR polymerase (PARP) family and mediates ...
Liu J +10 more
europepmc +14 more sources
Beyond cell-cell adhesion [PDF]
Tissue Barriers, 2013 Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells. These multi-PDZ proteins exert crucial functions in the structural
Traweger, Andreas +10 more
openaire +4 more sources
ZO-2/Tjp2 suppresses Yap and Wwtr1/Taz-mediated hepatocyte to cholangiocyte transdifferentiation in the mouse liver. [PDF]
NPJ Regen Med, 2022 AbstractTJP2/ZO-2-inactivating mutations in humans cause progressive cholestatic liver disease. Liver-specific deletion of Tjp2 in the mouse (Tjp2 cKO mice) leads to mild progressive cholestasis without an overt degradation of the bile-blood barrier (BBB). These mice are more susceptible to cholic acid (CA) induced liver injury.
Xu J +5 more
europepmc +4 more sources
c-Abl Kinase Targets Tight Junction Protein ZO-2 in Regulation of Cell Migration and Morphology. [PDF]
FASEB JAbstractc-Abl is a non-receptor tyrosine kinase involved in the regulation of cell migration and morphogenesis, but underlying mechanism remains unclear. Here, we report the identification of tight junction protein ZO-2 as a bona fide substrate of c-Abl. We show that c-Abl directly binds to and phosphorylates the C-terminus of ZO-2.
Choi DE +5 more
europepmc +2 more sources
Context-dependent interactions among afadin, ZO-1, and actin filaments [PDF]
Cell Structure and FunctionAfadin and ZO-1 are actin-binding scaffold proteins localized at cell-cell junctions. Although these proteins contain multiple protein-binding motifs for various junctional proteins, their binding partners within cells are strictly regulated.
Yuji Nitta +10 more
doaj +2 more sources
Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]
PeerJ, 2022 Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah +4 more
doaj +2 more sources
Zonula occludens 2 and Cell-Cell Contacts Are Required for Normal Nuclear Shape in Epithelia
Cells, 2021 MAGUK protein ZO-2 is present at tight junctions (TJs) and nuclei. In MDCK ZO-2 knockdown (KD) cells, nuclei exhibit an irregular shape with lobules and indentations.
Christian Hernández-Guzmán +4 more
doaj +1 more source
Physicochemical properties and effect of bioceramic root canal filling for primary teeth on osteoblast biology [PDF]
Journal of Applied Oral Science, 2021 Bio-C Pulpecto (Bio-CP) was recently developed as the first bioceramic root filling material for primary teeth. Objective To evaluate the physicochemical properties of radiopacity, setting time, pH, cytocompatibility and potential of Bio-CP to induce ...
Victor Manuel OCHOA RODRÍGUEZ +5 more
doaj +1 more source
Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.
Nafiseh Pakravan +2 more
doaj +1 more source
Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells. [PDF]
PLoS ONE, 2017 Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined.To investigate the contributory role of TJ ...
Sua Kim, Gheun-Ho Kim
doaj +1 more source