Results 191 to 200 of about 67,145 (262)

Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation

Small, EarlyView.
A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul, Cédric Bergerbit, Iulia Scarlat, Teodora Piskova, Vasudha Turuvekere Krishnamurthy, Aleksandra N. Kozyrina, Stacy Lok Sze Yam, Laura De Laporte, Jacopo Di Russo   +8 more
wiley   +1 more source

Inulin‐Butyrate Nanogel for Modulation of Gut Microbiome, Intestinal Barrier, and Regulatory T‐Cells in Colitis

Small, EarlyView.
IBD is driven by a vicious cycle of dysbiosis, barrier dysfunction, and immune dysregulation. We developed an inulin–butyrate conjugate nanogel (IBN) that accumulates in inflamed colon and releases butyrate via microbial inulinase/esterase. The inulin shell remodels the microbiome, while localized butyrate strengthens barrier integrity and promotes ...
Nayoon Park, Bom Lee, Hyeon‐Jeong Jeon, Ji Yeon Kim, Suyeon Park, Seong‐Eun Kim, Dong‐Kyu Lee, Yonghyun Lee   +7 more
wiley   +1 more source

Oxytocin supports the barrier integrity of brain endothelial cells via oxytocin receptors. [PDF]

J Neuroendocrinol
Paolini C, Piacentini F, Amato S, Busnelli M, Chini B.   +4 more
europepmc   +1 more source

Mesoporous Silica Nanoparticles‐Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin

Small, EarlyView.
This work explores the tailored functionalization of mesoporous silica nanoparticles (MSN) to improve the oral delivery of insulin, as a case study. Insulin confinement within silica mesopores increased drug solubility, and co‐formulation with succinylated β‐lactoglobulin yielded pH‐responsive tablets that limited gastric release and proteolysis, while
Claudia Iriarte‐Mesa, Estelle Juère, Andrea Bileck, Thomas Kremsmayr, Michael L. Goodson, Allison Ehrlich, Adnan Hodžić, Martin Kunert, Christopher Gerner, Hanspeter Kählig, Doris Marko, Markus Muttenthaler, David Berry, Giorgia Del Favero, Freddy Kleitz   +14 more
wiley   +1 more source

UNH: LESI Remains Flat as Lodging Executives Sentiment Continues to Slip [PDF]

, 2014
Mantz, Erika
core   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Protective Effects of Gallic Acid in LPS-Induced Lung Injury via Modulation of Oxidative Stress: AKT1/NRF2 and IL-10 Signaling. [PDF]

J Biochem Mol Toxicol
Unal O, Asci H, Selcuk E, Milletsever A, Tepebasi MY, Asci Y, Gulal A, Ozmen O.   +7 more
europepmc   +1 more source

Space biomedicine‐oriented bioink and biomimetic blood‒brain barrier

VIEW, EarlyView.
Bioinks and bioprinting play a pivotal role in the successful delivery of cell models and the fabrication of tissue models for space biomedicine research. This study investigated the effects of hypergravity and vibration on two‐dimensional adherent cells and three‐dimensional embedded cells and provided methods for storing hybrid bioink and high ...
Ranran Yan, Ge Gao, YuJuan Li, YuLin Deng   +3 more
wiley   +1 more source

Roles of Tight Junction Proteins in Intestinal Barrier Function and Health of Weaned Piglets: A Review. [PDF]

Vet Sci
Zhang S, Zhang G, Xu J, Chen D, Yin C, Wang J, Jiang X, Wang C.   +7 more
europepmc   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source