Results 1 to 10 of about 29,338 (190)

Activated complement protein C5a does not affect brain-derived endothelial cell viability and zonula occludens-1 levels following oxygen-glucose deprivation [PDF]

Brain Circulation, 2017
BACKGROUND AND PURPOSE: Ischemic brain injury induces both functional and structural disarray affecting the blood–brain barrier (BBB) which in return aggravates stroke outcomes.
Aren Khoyetsyan, Rachid Kacimi, Gohar Tsakanova, Anna Boyajyan, Arsen Arakelyan, Midori A Yenari   +5 more
doaj   +5 more sources

Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution

Journal of Pharmacological Sciences, 2008
Aspirin and nonsteroidal anti-inflammatory agents are known to induce gastroduodenal complications such as ulcer, bleeding, and dyspepsia. In this study, we examined the prophylactic effect of rebamipide, an anti-ulcer agent with free-radical scavenging ...
Takahiro Suzuki, Norimasa Yoshida, Nami Nakabe, Yutaka Isozaki, Hirokazu Kajikawa, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Hiroshi Ichikawa, Yuji Naito, Hirofumi Matsui, Toshikazu Yoshikawa   +11 more
doaj   +4 more sources

Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation

Infection and Immunity
Rickettsia spp. cause life-threatening diseases in humans. The fundamental pathophysiological changes in fatal rickettsial diseases are disrupted endothelial barrier and increased microvascular permeability.
Loka Reddy Velatooru, Esteban Arroyave, Meagan D. Rippee-Brooks, Megan Burch, Ethan Yang, Bing Zhu, David H. Walker, Yang Zhang, Rong Fang   +8 more
doaj   +3 more sources

Role of Rab13, Protein Kinase A, and Zonula Occludens-1 in Hepatitis E Virus Entry and Cell-to-Cell Spread: Comparative Analysis of Quasi-Enveloped and Non-Enveloped Forms

Pathogens
Hepatitis E virus (HEV) exists in two distinct forms: a non-enveloped form (neHEV), which is present in feces and bile, and a quasi-enveloped form (eHEV), found in circulating blood and culture supernatants. This study aimed to elucidate the roles of Ras-
Shigeo Nagashima, Putu Prathiwi Primadharsini, Masaharu Takahashi, Takashi Nishiyama, Kazumoto Murata, Hiroaki Okamoto   +5 more
doaj   +3 more sources

Effects of acute and chronic disease on cell junctions in mouse liver

EXCLI Journal : Experimental and Clinical Sciences, 2023
Cell junctions, including anchoring, occluding and communicating junctions, play an indispensable role in tissue architecture and homeostasis. Consequently, malfunctioning of cell junctions is linked with a wide range of disorders, including in liver ...
Raf Van Campenhout, Bruno Cogliati, Mathieu Vinken   +2 more
doaj   +1 more source

Effects of dietary Clostridium butyricum on the growth performance and intestinal health of hybrid groupers (Epinephelus lanceolatus♂ × E. fuscoguttatus♀)

Aquaculture Reports, 2023
s: This trial was performed to investigate the effects of Clostridium butyricum on growth and intestinal health of hybrid groupers (Epinephelus lanceolatus♂ × E. fuscoguttatus♀). 300 hybrid groupers were fed five diets containing C.
Keng Yang, Pengwei Xun, Jianbin Huang, Kui Jiang, Xiaolin Huang, Wei Yu, Chuangwen Xu, Heizhao Lin   +7 more
doaj   +1 more source

Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina [PDF]

Neuroscience, 2006
Most gap junctions between neurons in mammalian retina contain abundant connexin36, often in association with the scaffolding protein zonula occludens-1. We now investigate co-association of connexin36, zonula occludens-1, zonula occludens-2 and Y-box transcription factor 3 (zonula occludens-1-associated nucleic acid-binding protein) in mouse and rat ...
C, Ciolofan, X-B, Li, C, Olson, N, Kamasawa, B R, Gebhardt, T, Yasumura, M, Morita, J E, Rash, J I, Nagy   +8 more
openaire   +2 more sources

The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner

Biomolecules, 2021
The Cx43 carboxyl-terminus (CT) mimetic peptide, αCT1, originally designed to bind to Zonula Occludens 1 (ZO1) and thereby inhibit Cx43/ZO1 interaction, was used as a tool to probe the role of Cx43/ZO1 association in regulation of epithelial/endothelial ...
Randy E. Strauss, Louisa Mezache, Rengasayee Veeraraghavan, Robert G. Gourdie   +3 more
doaj   +1 more source

INVESTİGATİON OF ZONULA OCCLUDENS-1 PROTEİN LEVEL İN RECTUM TİSSUE AFTER RADİOTHERAPY

International Journal of Research -GRANTHAALAYAH, 2020
The transmembrane protein zonula occludens of rectal tissue has function to prevents the spread of bacterial toxins into the intestinal mucosa and to systemic circulation. But radiotherapy causes ablation of crypt cell proliferation, mitotic catastrophe, and apoptosis leading to gastrointestinal mucositis.
Cengiz Kurtman, Esra Gümüştepe, Serdağ Demirören, Fatma Firat, Şaban Çakır Gökçe, Kemal Özbilgin   +5 more
openaire   +2 more sources

The Carboxyl Terminus of Neph Family Members Binds to the PDZ Domain Protein Zonula Occludens-1 [PDF]

Journal of Biological Chemistry, 2003
The PSD95/Dlg/ZO-1 (PDZ) domain-containing protein zonula occludens-1 (ZO-1) selectively localizes to the cytoplasmic basis of the slit diaphragm, a specialized cell-cell contact in between glomerular podocytes necessary to prevent the loss of protein in the urine. However, the function of ZO-1 at the slit diaphragm has remained elusive.
Huber, Tobias B., Schmidts, Miriam, Gerke, Peter, Schermer, Bernhard, Zahn, Anne Katharina, Hartleben, Björn, Sellin, Lorenz, Walz, Gerd, Benzing, Thomas   +8 more
openaire   +3 more sources