Results 111 to 120 of about 31,457 (207)

Inhibition of MicroRNA‐155 Supports Endothelial Tight Junction Integrity Following Oxygen‐Glucose Deprivation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Brain microvascular endothelial cells form a highly selective blood brain barrier regulated by the endothelial tight junctions. Cerebral ischemia selectively targets tight junction protein complexes, which leads to significant damage to ...
Juan Carlos Pena‐Philippides, Amy Sabrina Gardiner, Ernesto Caballero‐Garrido, Rong Pan, Yiliang Zhu, Tamara Roitbak   +5 more
doaj   +1 more source

Heat‐Not‐Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes

Allergy, EarlyView.
Comparative analysis between cigarette smokers and HnB users revealed similar inflammatory lung function parameters and immunophenotypic patterns. Cigarette smoke and HnB aerosol had an impact on ECM through divergent downstream pathways. Exposed to Cigarette smoke and HnB aerosol caused comparative TJ weakening in the epithelial barrier.
Dilara Karaguzel, Alicja Walewska, Basak Ezgi Sarac, Marlena Tynecka, Kinga Bondarczuk, Agnieszka Tarasik, Dariusz Kisiel, Karolina Partyk, Damian Pogodziński, Bartosz Hanczaruk, Alicja Toczydlowska, Cagla Bicakci, Doga Oztabak, Magdalena Niemira, Adam Kretowski, Marlena Dubatowka, Natalia Ogrodnik, Malgorzata Chlabicz, Pawel Sowa, Karol Kaminski, Marcin Moniuszko, Andrzej Eljaszewicz, Cagatay Karaaslan   +22 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction

AIDS Research and Therapy, 2009
Background HIV-infected individuals are at increased risk for acute and chronic airway disease even though there is no evidence that the virus can infect the lung epithelium.
Jacob Barbara A, Joshi Pratibha C, Fan Xian, Lassiter Coy, Sutliff Roy L, Jones Dean P, Koval Michael, Guidot David M   +7 more
doaj   +1 more source

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling [PDF]

, 2010
he Hippo pathway regulates the size of organs by controlling two opposing processes: proliferation and apoptosis. YAP2 (Yes kinase-associated protein 2), one of the three isoforms of YAP, is a WW domain-containing transcriptional co-activator that acts ...
Bader, Gary D, Boucherie, Ciska, Gettemans, Jan, Gfeller, David, Meerschaert, Kris, Oka, Tsutomu, Remue, Eline, Sidhu, Sachdev S, Sudol, Marius, Vandekerckhove, Joël, Vanloo, Berlinda   +10 more
core   +2 more sources

Zonula Occludens‐1 and ‐2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions

Annals of the New York Academy of Sciences, 2009
The integrity of the tight junction barrier in epithelial and endothelial cells is critical to human health, but we still lack a detailed mechanistic knowledge of how the barrier is formed during development or responds to pathological and pharmacological insults. This limits our understanding of barrier dysfunction in disease and slows the development
Alan S, Fanning, James M, Anderson
openaire   +3 more sources

EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier

The FEBS Journal, EarlyView.
Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto, Gergő Porkoláb, Natalie Hudson, Jeffrey O'Callaghan, Nicole Hanley, Conor Delaney, Mária A. Deli, Peter Westenskow, Matthew Campbell   +8 more
wiley   +1 more source

A proper protocol for isolation of retinal pigment epithelium from rabbit eyes

Advanced Biomedical Research, 2014
Background: Retinal pigment epithelium (RPE) is a hexagonal monolayer of pigmented cells located between the neural retina and the choroid with an essential role for visual function.
Noushin Amirpour, Fereshteh Karamali, Shahnaz Razavi, Ebrahim Esfandiari, Mohammad Hossein Nasr-Esfahani   +4 more
doaj   +1 more source

Molecular And Immunological Characteristics Of Vibrio Cholerae And Vibrio Alginolyticus [PDF]

, 2000
Twenty isolates of Vibrio cholerae and four isolates of Vibrio alginolyticus used in this study were identified using the conventional biochemical tests.
Neela, Vasanthakumari
core