Results 81 to 90 of about 1,809,550 (296)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Thermomyces lanuginosus CBS 395.62/b Strain as Rich Source of
α-Galactosidase Enzyme

Food Technology and Biotechnology, 2003
Seventeen Thermomyces lanuginosus strains, cultivated on raffinose and sucrose, were ranked on the basis of
α-galactosidase activities. T. lanuginosus CBS 395.62/b strain showed the highest
α-galactosidase activity on both investigated carbohydrates ...
Quang D. Nguyen, Erika Bujna, Krisztina Takács, Magdolna Kovács, Ágoston Hoschke, Judit M. Rezessy-Szabó   +5 more
doaj  

Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. [PDF]

, 2019
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotemporal dementia. Most pathogenic GRN mutations result in progranulin haploinsufficiency, which is thought to cause frontotemporal dementia in GRN mutation ...
Arrant, Andrew E, Boyle, Nicholas R, Grinberg, Lea T, Hoffmann, Madelyn Q, Kashyap, Shreya N, Miller, Bruce L, Murchison, Charles F, Nana, Alissa L, Ramos, Eliana Marisa, Roberson, Erik D, Roth, Jonathan R, Seeley, William W, Spina, Salvatore   +12 more
core  

A classical phenotype of Anderson-Fabry disease in a female patient with intronic mutations of the GLA gene: a case report [PDF]

, 2012
Background: Fabry disease (FD) is a hereditary metabolic disorder caused by the partial or total inactivation of a lysosomal hydrolase, the enzyme α-galactosidase A (GLA). This inactivation is responsible for the storage of undegraded glycosphingolipids
Albeggiani, G, ALESSANDRO, Riccardo, COLOMBA, Paolo, Duro, G., Iemolo, F, Imbraco, M, Pisani, A, Zizzo, Carmela   +7 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Inter-familial and intra-familial phenotypic variability in three Sicilian families with Anderson-Fabry disease. [PDF]

, 2017
BACKGROUND: Anderson-Fabry disease (AFD) is an inborn lysosomal enzymopathy resulting from the deficient or absent activity of the lysosomal exogalactohydrolase, α-galactosidase A.
Colomba P, Corpora F, DAIDONE, Mario, Della Corte V, Di Chiara T, Duro G, Miceli S, Nucera A, Pecoraro R, Pinto A., Scaglione R, Simonetta I, Tuttolomondo A, VOGIATZIS, Danai, Zizzo C   +14 more
core   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Inhibition of β-galactosidase and α-glucosidase synthesis in petroleum refinery effluent bacteria by phenolic compounds

Revista Ambiente & Água, 2011
Inhibition of α-glucosidase (EC 3.2.1.20) and β-galactosidase (EC 3.2.1.23) biosynthesis by phenolic compounds (phenol, 2-chlorophenol, 4-chlorophenol, 4-bromophenol and 3,5-dimethylphenol) in Escherichia coli, Bacillus and Pseudomonas species isolated ...
Gideon C. Okpokwasili, Christian O. Nweke   +1 more
doaj   +1 more source

Multiplexed detection and differentiation of bacterial enzymes and bacteria by color-encoded sensor hydrogels

Bioactive Materials, 2021
We report on the fabrication and characterization of color-encoded chitosan hydrogels for the rapid, sensitive and specific detection of bacterial enzymes as well as the selective detection of a set of tested bacteria through characteristic enzyme ...
Zhiyuan Jia, Mareike Müller, Tony Le Gall, Martijn Riool, Max Müller, Sebastian A.J. Zaat, Tristan Montier, Holger Schönherr   +7 more
doaj   +1 more source

Production of Mannan-Degrading Enzymes by Aspergillus Niger in Shake Flasks and Stirred Tank Fermenter [PDF]

, 2005
Optimization of medium composition and culture conditions for mannan-degrading enzymes production by Aspergillus niger was carried out in shake flasks and 2 L stirred tank fermenter.
Mohamad, Siti Norita
core