Results 101 to 110 of about 25,536 (213)

Cyclic isoDGR peptidomimetics: biological evaluation as integrin antagonists and synthesis of tumor-homing conjugates [PDF]

, 2016
Integrins are a large family of cell adhesion receptors composed of two non-covalently bound α and β transmembrane glycoproteins and are involved in important physiological and pathological processes.[1] Several integrins, including αVβ3, αVβ5, α5β1, and
D. Arosio, M. Paolillo, L. Pignataro, L. Belvisi, S. Schinelli, C. Gennari, S. Panzeri, U. Piarulli, S. Zanella, S. Angerani, A. Dal Corso   +10 more
core  

Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells.

PLoS ONE, 2012
BackgroundIntegrins are a family of transmembrane adhesion proteins that mediate cell adhesion and intracellular signaling. Integrin-αvβ3 is expressed on the surface of human glioblastoma cells, and can be further induced by chemical stress.
Ming-Wei Chang, Jem-Mau Lo, Hsueh-Fen Juan, Hsin-Yi Chang, Chun-Yu Chuang   +4 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Abstract 3841: An integrin αvβ3/c-Src oncogenic unit promotes anchorage independence and tumor progression [PDF]

, 2010
Integrins regulate adhesion-dependent growth, survival and invasion of tumor cells. In particular, expression of integrin αvβ3 is associated with progression of a variety of human tumors.
Jay S. Desgrosellier, Sanford J. Shattil, Laetitia Seguin, Steven K. Lau, Miller Huang, David A. Cheresh, David J. Shields, Nicolas Prevost, Leo A. Barnes, David Tarin   +9 more
core   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis [PDF]

, 2019
Osteoarthritis (OA) is the leading cause of joint failure, yet the underlying mechanisms remain elusive, and no approved therapies that slow progression exist. Dysregulated integrin function was previously implicated in OA pathogenesis.
Jeremy Sokolove, Cecilia T. Cisar, Willingham, Stephen, Lepus, Christin, Sohn, Dong, Wong, Heidi, Raghu, Harini, Lingampalli, Nithya, Eileen E. Elliott, Heidi Wong, Kazuhiro Onuma, Robinson, William, Zhen Cheng, Bloom, Michelle, Cisar, Cecilia, Prohaska, Susan, Constance R. Chu, Rong Mao, Zhao, Xiaoyan, Irving L. Weissman, Dong Hyun Sohn, Richard R.L. Cao, Liu, Changhao, Nick Hu, Qian Wang, Xiaoyan Zhao, Sharpe, Orr, Weissman, Irving, Cao, Richard, Michelle S. Bloom, Changhao Liu, Sokolove, Jeremy, Nithya Lingampalli, Hu, Nick, Christin M. Lepus, Harini Raghu, Onuma, Kazuhiro, Nicholas J. Giori, Susan S. Prohaska, Cheng, Zhen, Chu, Constance, Orr Sharpe, William H. Robinson, Giori, Nicholas, Wang, Qian, Elliott, Eileen, Stephen B. Willingham, Mao, Rong   +47 more
core   +1 more source

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment

Immunology &Cell Biology, EarlyView.
Three interconnected processes in glioblastoma (GBM) biology: initiation, stratification, and immunosuppression. 1) Initiation: GBM initiation is proposed to occur through migration of TERT mutation‐bearing neural stem cells from the subventricular zone to the frontal and temporal cortices, where a subsequent oncogenic transformation drives their ...
Emerson Achari, Farah Ahmady‐Nield, Amit Sharma, Ingo G. H. Schmidt‐Wolf, Jarek Maciaczyk, Rodney B. Luwor, Adrian A. Achuthan   +6 more
wiley   +1 more source

Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity [PDF]

, 2016
The selective targeting of the αvβ3 integrin subtype without affecting the structurally closely related receptor α5β1 is crucial for understanding the details of their biological and pathological functions and thus of great relevance for diagnostic and ...
Francesco Saverio Di Leva (1745107), Carlos Mas-Moruno (1659775), Horst Kessler (71356), Margret Schottelius (1816879), Stefanie Neubauer (1816870), Luciana Marinelli (1264995), Ettore Novellino (333902), Richard Brimioulle (1614799), Alexander Bochen (1816873), Tariq R. Sobahi (1816876), Florian Rechenmacher (1816867)   +10 more
core   +1 more source

Emerging locally delivered antimicrobial and immunomodulatory approaches for the prevention/treatment of peri‐implant diseases

Periodontology 2000, EarlyView.
Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje, Ettore Amerio, Irene Mallor, Conrado Aparicio   +3 more
wiley   +1 more source

Additional file 2: of Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells [PDF]

, 2019
Figure S2. Colocalization of αvβ3 with DisBa-01; VEGFR2 and DisBa-01 + VEGFR2. (A) Integrin αvβ3 (green) and VEGFR2 (red) without DisBa-01 treatment. (B) Integrin αvβ3 (green) and DisBa-01 (red). Yellow regions in merged image = double colocalization. (C)
Taís Danilucci (6492674), Graziéle Pisani (6492683), Patty Santos (6492677), Bianca Pachane (6492680), Heloisa Selistre-de-Araujo (6492695), Wanessa Altei (6492692), Rafael Lino (6492686), Bruna Casali (6492689)   +7 more
core   +1 more source