Results 151 to 160 of about 25,536 (213)

It's Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals. [PDF]

Cancers (Basel), 2021
Kossatz S, Beer AJ, Notni J.
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, Volume 293, Issue 13, Page 3788-3813, July 2026.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study. [PDF]

Front Endocrinol (Lausanne), 2022
Tobi D, Krashin E, Davis PJ, Cody V, Ellis M, Ashur-Fabian O.   +5 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Beyond MIDAS: An <i>In Silico</i> Study of a Putative Noncanonical C16 Binding Site in αvβ3 Integrin. [PDF]

ACS Omega
de Andrade FDCP, Ferreira E Silva Y, Batista PR, Mendes AN.   +3 more
europepmc   +1 more source

The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro. [PDF]

Int J Mol Sci, 2022
Casali BC, Gozzer LT, Baptista MP, Altei WF, Selistre-de-Araújo HS.   +4 more
europepmc   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, Volume 293, Issue 13, Page 4064-4084, July 2026.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

MD Simulation of Vector-Receptor Pharmacologic Pairs for Tumor-Specific Drug Delivery: Transfer of Boron Atoms by RGD Peptide to αvβ3 Integrin Receptor. [PDF]

Curr Issues Mol Biol
Baigunov I, Kholmurodov K, Gafurzoda J, Husenzoda M, Gribova E, Gladyshev P, Slobodova D, Gorshkova R, Lipengolts A.   +8 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

A switch from α5β1 to αvβ3 integrin activity contributes to the development of a profibrotic mesenchymal phenotype in trabecular meshwork cells. [PDF]

Front Cell Dev Biol
Johns KL, Faralli JA, Filla MS, Shah N, Keller KE, Peters DM.   +5 more
europepmc   +1 more source