Results 141 to 150 of about 25,536 (213)

Current Landscape and Future Perspectives of Diabetic Retinopathy Therapy: Pharmacological Targets, Precision Laser Technology, and Clinical Evidence

MedComm, Volume 7, Issue 7, July 2026.
Targeted biological agents targeting VEGF, integrin, dopamine D2 receptor, ROCK, and BCL‐XL have entered the clinical trial phase and deserve particular attention. The treatment paradigm has shifted toward personalized and precision medicine, positioning optimized SML as a promising adjunctive therapy.
Xinying Hu, Zhe Cha, Ao Lu, Wuping Xu, Xiaoqing Zhang, Sheng Miao, Haiwei Xu, Xuedong Xu   +7 more
wiley   +1 more source

Integrin αvβ3-dependent pathogenic effect and therapeutic effects of DL-N2 combined with EGFR inhibitors in pancreatic adenocarcinoma

Journal of Translational Medicine
Background Pancreatic adenocarcinoma (PDAC) remains one of the most lethal malignancies, characterized by aggressive progression, pronounced stromal desmoplasia, and a limited response to targeted therapies.
Zi-Lin Li, Sachin Kumar, San-Nan Yang, Tung-Cheng Chang, Lin-Yi Huang, Ching-Chung Ko, Yung-Ning Yang, Chih-Jung Yao, Dana R. Crawford, Fabio Gionfra, Dahlak Daniel Solomon, Yung-Kuo Lee, Do Thi Minh Xuan, Hui-Ru Lin, Chih-Yang Wang, Amruta Aher, Nandana Bayu Abhista, Ya-Jung Shih, Sheng-Yang Lee, Haw-Ming Huang, Hung-Yun Lin, Kuan Wang, Jaqueline Whang-Peng   +22 more
doaj   +1 more source

Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management

MedComm, Volume 7, Issue 7, July 2026.
Global epidemiology, integrated determinants, and disease burden of endometriosis. This circular schematic comprehensively illustrates the global prevalence and demographic variation of endometriosis, its multifactorial integrated determinants, the multifaceted disease burden and economic impact, and recent epidemiological trends, providing a holistic ...
Kun Wang, Dongyun He, Yang Wang, Xiaojun Liu, Li Liu   +4 more
wiley   +1 more source

Cyclic isoDGR peptidomimetics as low-nanomolar αvβ3 integrin ligands [PDF]

, 2013
Integrins are a large family of heterodimeric transmembrane glycoprotein receptors, composed of two noncovalently associated subunits (α and β). Integrins αVβ3 and αVβ5 have been found to be overexpressed on blood vessels in human tumors, but not on ...
D. Arosio, I. Guzzetti, M. Civera, L. Pignataro, M. Mingozzi, L. Belvisi, C. Gennari, U. Piarulli, M. Marchini, D. Potenza, A. Dal Corso   +10 more
core  

An αvβ3 integrin checkpoint is critical for efficient T_H2 cell cytokine polarization and potentiation of antigen-specific immunity. [PDF]

Nat Immunol, 2023
Szeto ACH, Ferreira ACF, Mannion J, Clark PA, Sivasubramaniam M, Heycock MWD, Crisp A, Jolin HE, Kozik P, Knolle MD, McKenzie ANJ.   +10 more
europepmc   +1 more source

Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025

Molecular Genetics &Genomic Medicine, Volume 14, Issue 7, July 2026.
This bibliometric analysis outlines global research trends, collaborations, and hotspots of Alport syndrome, offering references for future basic research and clinical management. ABSTRACT Background Alport syndrome (AS) is a multisystem hereditary disorder characterized by persistent hematuria, progressive renal insufficiency, sensorineural hearing ...
Xiujuan Cao, Wei Zhou, Yong Wang, Lvxian Wu, Jianhua Mao   +4 more
wiley   +1 more source

αvβ3 integrin-specific exosomes engineered with cyclopeptide for targeted delivery of triptolide against malignant melanoma. [PDF]

J Nanobiotechnology, 2022
Gu Y, Du Y, Jiang L, Tang X, Li A, Zhao Y, Lang Y, Liu X, Liu J.   +8 more
europepmc   +1 more source

Single Cell Mechanics in Disease Progression

Small Science, Volume 6, Issue 7, July 2026.
Cells transmit distinct mechanical forces through ECM adhesion and cell–cell junctions and actomyosin‐generated traction forces are transmitted to the substrate through integrin‐based focal adhesions. Mechanical signals are further transmitted to the nucleus via the LINC complex, connecting the cytoskeleton to the nuclear lamina. These forces integrate
Sabin Kim, Jongmin Lee, Kyungtae Lim, Dong‐Hwee Kim   +3 more
wiley   +1 more source

RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes. [PDF]

Biochim Biophys Acta Mol Basis Dis, 2021
Kim EY, Dryer SE.
europepmc   +1 more source

Engineering Extracellular Vesicles for Anti‐Aging Therapy: Mechanisms, Applications, and Perspectives

Aging Cell, Volume 25, Issue 7, July 2026.
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang, Qiujie Li, Guofang Tao, Xulin Gan, Jiangjie Lu, Sergei Krasny, Liyun Shi   +6 more
wiley   +1 more source