Results 121 to 130 of about 25,536 (213)
Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence
Communications ChemistryBicyclic peptides, which integrate the advantageous properties of small molecules and antibodies, have emerged as a promising class of therapeutic candidates.
Haijian Yang +9 more
doaj +1 more source
Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues
Advanced Materials Interfaces, Volume 13, Issue 13, 7 July 2026.ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike +3 more
wiley +1 more source
Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy
Advanced Science, Volume 13, Issue 39, 13 July 2026.Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee +11 more
wiley +1 more source
αvβ3 integrin mediated drug resistance in human tongue squamous cell carcinoma [PDF]
, 2009 Otpornost posredovana integrinom temelji se na prihvaćanju stanica za proteine izvanstaničnog matriksa putem integrina. Na modelu ljudskih stanica karcinoma grkljana opisan je mehanizam otpornosti na citostatike posredovan αvβ3 integrinom.
Stojanović, Nikolina
core
Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
Advanced Science, Volume 13, Issue 39, 13 July 2026.A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 38, 9 July 2026.A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 40, 17 July 2026.Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim +2 more
wiley +1 more source
Aggregate, Volume 7, Issue 7, July 2026.A systematic preclinical workflow demonstrates the utility of an integrin‐targeted NIR‐II fluorescent probe for gastric cancer resection. This zwitterionic molecular tracer minimizes nonspecific background signals to achieve high contrast imaging.
Xiaolong Liu +10 more
wiley +1 more source
αvβ3 Integrin as a Link between the Development of Fibrosis and Thyroid Hormones in Systemic Sclerosis. [PDF]
Int J Mol Sci, 2023 Kohon MY +7 more
europepmc +1 more source
Cancer Medicine, Volume 15, Issue 7, July 2026.ABSTRACT Background Epithelial‐mesenchymal transition (EMT) is a cellular process involved in the invasion and metastasis of cancer cells. Deregulated cellular cholesterol is associated with treatment resistance and metastatic potential in cancer cells; however, the link between EMT and cholesterol is unclear.
Shanen Perumal +3 more
wiley +1 more source