Results 121 to 130 of about 35,992 (209)
An update on the landscape of collagen bioactive fragments
The FEBS Journal, EarlyView.The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley +1 more source
A Role for Integrin avß3 in Invasion Activity of Highly Metastatic Syrian Hamster Fibroblasts [PDF]
, 2004 The expression of extracellular matrix (ECM) specific receptors, integrins, was investigated in two closely related strains of oncogenically transformed fibroblasts drastically differing in spontaneous metastasizing. The highly metastatic cells (HM) were
Berman, A. E. +2 more
core
The FEBS Journal, EarlyView.The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka +3 more
wiley +1 more source
Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, EarlyView.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
Periodontology 2000, EarlyView.Abstract Peri‐implant diseases are dysbiosis‐mediated inflammatory disorders that occur in susceptible hosts. Antimicrobials and immunomodulatory agents therefore might be pertinent as adjunctive measures in the treatment of such disorders. The aim of this narrative review was to examine the existing evidence and assess the effectiveness of emerging ...
Alberto Monje +3 more
wiley +1 more source
Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence
Communications ChemistryBicyclic peptides, which integrate the advantageous properties of small molecules and antibodies, have emerged as a promising class of therapeutic candidates.
Haijian Yang +9 more
doaj +1 more source
RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling
Glia, Volume 74, Issue 6, June 2026.Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro +4 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.MFAP4 deficiency exacerbates heatstroke outcomes, accelerating hyperthermia, delaying recovery, reducing survival, and worsening cardiac injury. Conversely, MFAP4 overexpression enhances cellular thermoresistance. MFAP4 orchestrates transcriptional reprogramming in response to HS.
LiJun Fan +8 more
wiley +1 more source
Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Daniela Enriquez‐Ochoa +12 more
wiley +1 more source