Results 51 to 60 of about 34,901 (267)

Resistance to carbapenems in non-typhoidal Salmonella enterica serovars from humans, animals and food [PDF]

, 2018
Non-typhoidal serovars of Salmonella enterica (NTS) are a leading cause of food-borne disease in animals and humans worldwide. Like other zoonotic bacteria, NTS have the potential to act as reservoirs and vehicles for the transmission of antimicrobial ...
Fernández, J., Guerra, B., Rodicio Rodicio, María del Rosario   +2 more
core   +3 more sources

Expression of ESBL, MBL and AmpC β lactamases by extra intestinal Escherichia coli isolates: correlation with treatment and clinical outcome [PDF]

Journal of Microbiology and Infectious Diseases, 2013
Objective:We investigated the expression of Extended Spectrum β-Lactamases (ESBLs), AmpC β lactamases and Carbapenemases in extraintestinal pathogenic Escherichia coli (ExPEC) isolates and correlated with treatment and outcome of the patients. Methods:
Arindam Chakraborty , Prabha Adhikari , Shalini Shenoy , Shrikala Baliga , Satish Rao , Dhanashree Biranthabail , Vishwas Saralaya   +6 more
doaj   +1 more source

Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases [PDF]

, 2015
The breakdown of antibiotics by β-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors
A Bloor, A Brooun, A Ross-Gillespie, A Ross-Gillespie, AS Hackman, B Raymond, B Raymond, Ben Raymond, BR Levin, C Dahlberg, D Clark, DA Mitchison, DM Livermore, E Tuomanen, EA Yurtsev, Frances Medaney, G Rolinson, GL Hobby, HC Neu, I Brook, I Brook, JJ Harrison, JL Cottell, JW Bigger, K Datsenko, K Lewis, K Lewis, K Lewis, K Sandoz, L Dugatkin, L Zhou, M Doebeli, M Ghoul, MH Perlin, NQ Balaban, O Ciofu, PS Stewart, R Ellis, R Lenski, R Lenski, R Tacking, Richard J Ellis, RJ Worthington, RM Cozens, RN Jones, S Brown, SA West, SA West, SP Brown, SP Diggle, Tatiana Dimitriu, X-X Zhang, XX Zhang   +52 more
core   +1 more source

Biochemical characterization of CTX-M-15 from Enterobacter cloacae and designing a novel non-β-lactam-β-lactamase inhibitor. [PDF]

PLoS ONE, 2013
The worldwide dissemination of CTX-M type β-lactamases is a threat to human health. Previously, we have reported the spread of bla(CTX-M-15) gene in different clinical strains of Enterobacteriaceae from the hospital settings of Aligarh in north India. In
Mohammad Faheem, Md Tabish Rehman, Mohd Danishuddin, Asad U Khan   +3 more
doaj   +1 more source

Cyclic Boronates Inhibit All Classes of β-Lactamase [PDF]

, 2017
β-Lactamase-mediated resistance is a growing threat to the continued use of β-lactam antibiotics. The use of the β-lactam-based serine-β-lactamase (SBL) inhibitors clavulanic acid, sulbactam, tazobactam, and, more recently, the non-β-lactam inhibitor ...
Brem, J, Cahill, ST, Cain, R, Fishwick, CWG, Lohans, CT, McDonough, MA, Mohammed, J, Oswin, HP, Schofield, CJ, Spencer, J, Wang, DY, Wareham, DW   +11 more
core   +5 more sources

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model

Antimicrobial Resistance and Infection Control, 2018
Treating M. abscessus infection is challenging due to the potent β-lactamase BlaMab (Beta-lactamase of M. abscessus ). Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit BlaMab.
Michal Meir, Pablo Bifani, Daniel Barkan
doaj   +1 more source

Creation and assessment of a clinical predictive calculator and mortality associated with Candida krusei bloodstream infections [PDF]

, 2018
Background Candida krusei bloodstream infection (CK BSI) is associated with high mortality, but whether this is due to underlying comorbidities in affected patients or the organism itself is unknown.
Hsueh, Kevin, Kronen, Ryan, Lin, Charlotte, Powderly, William G, Spec, Andrej   +4 more
core   +2 more sources

DOTA‐grafted Cationic Polymers Behaving as Powerful Macromolecular Resistance‐reversal Agents (MRRAs) Combating Against New Delhi Metallo‐β‐lactamase (NDM)‐producing Bacteria

Advanced Science, EarlyView.
Two macromolecular resistance‐reversal agents (MRRAs)—linear (MRRAL) and nanostructured (MRRAN) polymers were fabricated by integrating DOTA motifs into tunable polycationic scaffolds. MRRAs exhibit superior antibacterial potency once combined with meropenem (MEM) through (i) bacterial membrane disruption via localized cationic charge and ...
Ruixue Wang, Jian Zhang, Yun li, Liping Qiao, Zhuorui Dong, Dandan Cui, Peirong Bai, Liping Li, Bing Cao, Ruiping Zhang   +9 more
wiley   +1 more source

Paradoxical Hypersusceptibility of Drug-resistant Mycobacterium tuberculosis to β-lactam Antibiotics

EBioMedicine, 2016
Mycobacterium tuberculosis (M. tuberculosis) is considered innately resistant to β-lactam antibiotics. However, there is evidence that susceptibility to β-lactam antibiotics in combination with β–lactamase inhibitors is variable among clinical isolates ...
Keira A. Cohen, Tal El-Hay, Kelly L. Wyres, Omer Weissbrod, Vanisha Munsamy, Chen Yanover, Ranit Aharonov, Oded Shaham, Thomas C. Conway, Yaara Goldschmidt, William R. Bishai, Alexander S. Pym   +11 more
doaj   +1 more source