Results 161 to 170 of about 37,330 (229)

Evaluating the Educational Value of Artificial Intelligence in Pharmacotherapy Education

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Final‐year medical students frequently make prescribing errors, partly because they have had insufficient training in therapeutic reasoning. Students need to understand the underlying rationale behind a drug choice in order to subsequently apply that knowledge critically and independently.
Mariëlle G. Hartjes, Michiel J. Bakkum, Milan C. Richir, Michiel A. van Agtmael, Jelle Tichelaar   +4 more
wiley   +1 more source

Polyphenols as Potential β-Lactamase Inhibitors: An Integrated Computational and Experimental Study. [PDF]

Molecules
Mourabiti F, Jouga F, Calvo LG, Villarino RA, Zouheir Y, Soukri A, de Miguel T, El Khalfi B.   +7 more
europepmc   +1 more source

A novel fusion tool to enable G protein‐coupled receptor structure determination

Acta Crystallographica Section D, Volume 82, Issue 6, Page 655-663, June 2026.
The development of a new fusion tool in which a β‐lactamase fusion tag and a binding partner enabled the structure determination of an antagonist‐bound G protein‐coupled receptor by cryo‐EM is reported.Structure determination of G protein‐coupled receptors (GPCRs) plays an important role in accelerating drug development against this medically important
Nita R. Shah, Mathieu Oosterlaken, Claudine Bisson, Mattia Bertinelli, Alicia M. Churchill-Angus, Andrew Hutchin, Jola Kopec, Vadim Kotov, Ciaran R. McFarlane, Erika Griss Pascualli, Ana Pavic, Matthias Zebisch, Cédric Fiez-Vandal, Edoardo Fabini, Stéphanie Duclos   +14 more
wiley   +1 more source

Repurposing insights: experimental and pharmacological approach on L-captopril and dimercaprol as metallo-β-lactamase inhibitors. [PDF]

FEMS Microbiol Lett
Rodríguez-Avial I, Torres S, Puglla Y, Pérez-Martín L, Sebastianes JL, Delgado-Iribarren A, Culebras E, Valderrama MJ.   +7 more
europepmc   +1 more source

Cefdinir binding to a class A β‐lactamase revealed by serial cryo‐crystallography

Acta Crystallographica Section D, Volume 82, Issue 6, Page 672-682, June 2026.
Serial cryo‐crystallography reveals the structure of the extended‐spectrum β‐lactamase CTX‐M‐14 in complex with the third‐generation cephalosporin antibiotic cefdinir.One of the most common resistance mechanisms against antibiotics employed by Gram‐negative bacteria involves the production of β‐lactamases, resulting in rapid hydrolysis of the ...
Gargi Gore, Andreas Prester, Kim Bartels, David von Stetten, Eike C. Schulz   +4 more
wiley   +1 more source

Comparative analysis of the effects of aztreonam combined with four β-lactamase inhibitors against carbapenem-resistant <i>Enterobacterales</i>. [PDF]

Microbiol Spectr
Meng Q, Xu C, Li W, Shen K, Huang X, Fu X, Zhou L, Chen Y, Hu F, Wang H.   +9 more
europepmc   +1 more source

Species‐Specific Optimisation and Environmental Regulation of Biofilm Formation in Enterobacter cloacae: Inhibitory Role of Glucose in Biofilm Development

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study demonstrates that mild salinity stress (1%–2% NaCl) significantly enhances biofilm formation in Enterobacter cloacae. Using a standardised 96‐well microtiter plate assay, we optimised in vitro biofilm quantification and classification, providing a reproducible framework for studying environmental and clinical biofilm development mechanisms ...
Srishti Singh, Virendra Bahadur Yadav, Alok Kumar Singh, Gopal Nath, Sasmita Chand, Nirmalendu Sekhar Mishra, Jagdeep Kumar Nayak   +6 more
wiley   +1 more source

In vitro and in vivo evaluation of two combined β-lactamase inhibitors against carbapenem-resistant Acinetobacter baumannii. [PDF]

Eur J Clin Microbiol Infect Dis, 2023
Domínguez AV, Panadero IM, Smani Y.
europepmc   +1 more source

Altered Pathogen Spectrum of Spontaneous Bacterial Peritonitis in Patients Treated With Proton Pump Inhibitors

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 11, Page 1487-1494, June 2026.
This multicenter, observational study reveals distinct alterations in the microbial spectrum of spontaneous bacterial peritonitis (SBP) associated with proton pump inhibitor use. These results are especially relevant for guiding empiric antibiotic therapy of SBP.
Philip Kitchen, Sarah L. Schütte, Tammo L. Tergast, Benjamin Maasoumy, Leonie Braun, Ulrich vor dem Esche, Georg Häcker, Marcus M. Mücke, Marlene Reincke, Michael Schultheiss, Robert Thimme, Siegbert Rieg, Dominik Bettinger, Lukas Sturm   +13 more
wiley   +1 more source

Carbapenems versus β-lactam and β-lactamase inhibitors for treatment of nosocomial pneumonia: A systematic review and meta-analysis. [PDF]

Heliyon, 2023
Cang HQ, Quan XH, Chu XH, Liang Y, Yang X, Li J.   +5 more
europepmc   +1 more source