Results 11 to 20 of about 1,672,197 (320)

Novel monoclonal antibodies for immunodetection of AmpC β-lactamases [PDF]

PeerJ
Background Accurate and easy-to-perform assays for the detection of antibiotic-resistant bacterial isolates producing AmpC β-lactamases are epidemiologically relevant, leading to more effective use of antibiotics and a comprehensive understanding of β ...
Karolina Bielskė, Martynas Simanavičius, Julie Nuttens, Julija Armalytė, Justas Dapkūnas, Lukas Valančauskas, Aurelija Žvirblienė   +6 more
doaj   +3 more sources

OXA β-lactamases [PDF]

Clinical Microbiology Reviews, 2014
The OXA β-lactamases were among the earliest β-lactamases detected; however, these molecular class D β-lactamases were originally relatively rare and always plasmid mediated.
Brink AJ, Espinal P, Goncalves D, Lyon JA, Potron A, Summers DK   +5 more
core   +3 more sources

Cooperative resistance varies among β-lactamases in E. coli, with some enabling cross-protection and sustained extracellular activity [PDF]

Communications Biology
β-lactamases confer bacteria resistance to β-lactam antibiotics, and interestingly, this protective effect can extend to neighboring susceptible cells. However, knowledge of this cooperative resistance remains limited.
Qinqin Wang, Shaodong Wei, Jonas Stenløkke Madsen   +2 more
doaj   +2 more sources

Characterization of acquired β-lactamases in Pseudomonas aeruginosa and quantification of their contributions to resistance [PDF]

Microbiology Spectrum
Pseudomonas aeruginosa is a highly problematic opportunistic pathogen that causes a range of different infections. Infections are commonly treated with β-lactam antibiotics, including cephalosporins, monobactams, penicillins, and carbapenems, with ...
Karl A. Glen, Iain L. Lamont
doaj   +2 more sources

Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data

Microbiome, 2017
Background Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics. These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and ...
Fanny Berglund, Nachiket P. Marathe, Tobias Österlund, Johan Bengtsson-Palme, Stathis Kotsakis, Carl-Fredrik Flach, D G Joakim Larsson, Erik Kristiansson   +7 more
doaj   +2 more sources

Enzyme graphene oxide interaction: the case system of β-lactamases. [PDF]

RSC Adv
This paper proves that graphene oxide is a potent non-competitive inhibitor for both serine- and metallo-β-lactamases. Its inhibitory effect is significantly diminished when preincubated with a substrate, indicating an oxidation-mediated mechanism.
Piccirilli A, Perilli M, Brisdelli F, Mastrippolito D, D'Olimpio G, Ershadrad S, Sanyal B, Ottaviano L.   +7 more
europepmc   +3 more sources

Antifungal agent tavaborole as a potential broad-spectrum serine and metallo-β-lactamases inhibitorResearch in context [PDF]

EBioMedicine
Summary: Background: The global emergence and spread of carbapenem-resistant Enterobacteriaceae in clinical settings have driven the search for inhibitors that can counteract carbapenemases.
Yan Zhang, Siyuan Yang, Zhaoju Deng, Huangwei Song, Ning Xie, Yunrui Tian, Shangshang Qin, Jifeng Liu, Yong Guo, Dongli Wang, Junfeng Liu, Congming Wu, Jianzhong Shen, Shizhen Ma, Yang Wang, Dejun Liu   +15 more
doaj   +2 more sources

OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles [PDF]

mBio
β-lactamases from Gram-negative bacteria are generally regarded as soluble, periplasmic enzymes. NDMs have been exceptionally characterized as lipoproteins anchored to the outer membrane. A bioinformatics study on all sequenced β-lactamases was performed
Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila   +6 more
doaj   +2 more sources

A review of SHV extended-spectrum β-lactamases: neglected yet ubiquitous

Frontiers in Microbiology, 2016
β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the 20st century, and they are now ...
Apostolos Liakopoulos, Dik Mevius, Dik Mevius, Daniela Ceccarelli   +3 more
doaj   +2 more sources

Prevalence of Extended Spectrum β-Lactamase, Metallo β-Lactamase, and AmpC β-Lactamase among Gram Negative Bacilli Recovered from Burn Wound Infection

RUHS Journal of Health Sciences, 2023
Introduction: Infections are the major cause of morbidity and mortality in burn patients. The ESBL, MBL and AmpC are the major mediators of antimicrobial resistance in gram negative bacteria. Early detection of ESBL, MBL and AmpC β -lactamases is crucial
Kusum Lata Lodha, Seema Surana
doaj   +1 more source