Results 21 to 30 of about 27,066 (205)
Metallo-β-Lactamases and Aptamer-Based Inhibition
Pharmaceuticals, 2011 An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the ...
Sung-Kun Kim +3 more
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Journal of Contemporary Medical Sciences, 2021 Objectives: This study aimed to determine the Enterobacteriaceae strains among patients who suffering diarrhea, phenotypic and genotypic characterization of ESBL-producing isolates in Jeddah, Saudi Arabia. Methods: Stool samples were collected and cultured to determine the different Enterobacteriaceae strains, PCR was done for the isolates to detect ...
Wafa A. Alshehri, Tarek A. A. Moussa
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β-Lactamase is encoded on plasmid pACK3 inStaphylococcus simulansbiovarstaphylolyticus [PDF]
FEMS Microbiology Letters, 1991 Abstract Staphylococcus simulans biovar staphylolyticus , the lysostaphin-producing organism, contains five plasmids designated pACK1 through pACK5. Hybridization analysis using cloned β-lactamase gene ( bla ) as probe and characterization of cured strains revealed that bla resides on pACK3 rather than on the lysostaphin endopeptidase plasmid ...
Harry E. Heath +3 more
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Antibiotics, 2014 The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae.
Nuno T. Antunes, Jed F. Fisher
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mBio, 2019 Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillinases (OXA), as ...
Melissa D. Barnes +16 more
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SUSCEPTIBILITY AND DETECTION OF EXTENDED SPECTRUM β-LACTAMASE ENZYMES FROM OTITIS MEDIA PATHOGENS [PDF]
American Journal of Infectious Diseases, 2013 Otitis media is the bacterial infection of the middle ear usually accompanied with inflammation, effusions and pain. It can present clinically in two major forms: Acute Otitis Media (AOM) and Otitis Media with Effusion (OME) and it is one of the leading cause of hospital visits and antibiotic prescriptions amongst children and even adults.
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F1000Research, 2020 Background: Pseudomonas aeruginosa is a pathogenic bacterium, causing nosocomial infections with intrinsic and acquired resistance mechanisms to a large group of antibiotics, including β-lactams.
Dina N. Abdelrahman +7 more
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Genomic analysis of bifunctional Class C-Class D β-lactamases in environmental bacteria
Memorias do Instituto Oswaldo Cruz, 2018 β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was
Melise Chaves Silveira +2 more
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Could β-Lactam Antibiotics Block Humoral Immunity?
Frontiers in Immunology, 2021 It has been reported that treatment with β-lactam antibiotics induces leukopenia and candidemia, worsens the clinical response to anticancer immunotherapy and decreases immune response to vaccination.
Cléa Melenotte +13 more
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Mutation of serine residue 318 in the class C β-lactamase ofEnterobacter cloacae908R [PDF]
FEMS Microbiology Letters, 1992 The involvement of the serine residue 318 in the specificity of a class C β-lactamase was investigated. Multiple site-directed mutants at this position were generated using a polymerase chain reaction technique. These mutants were then probed for their activity towards various β-lactam compounds.
Christine Jacobs +4 more
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