Results 101 to 110 of about 62,533 (281)

Synergistic Interaction Between Fentanyl and a Tramadol:Paracetamol Combination on the Inhibition of Nociception in Mice

Journal of Pharmacological Sciences, 2012
Multimodal analgesic approaches to manage acute and chronic pain are commonly used in humans. Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral
Víctor Fernández-Dueñas, Raquel Poveda, Sílvia Sánchez, Francisco Ciruela   +3 more
doaj   +1 more source

Emergence of Medetomidine in the Unregulated Drug Supply and Its Association With Hallucinogenic Effects

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction The unregulated drug supply in the United States is rapidly evolving, and veterinary tranquillisers have emerged as adulterants of concern, especially in illicitly‐manufactured fentanyl. Following the proliferation of xylazine, medetomidine, a more potent sedative, has recently appeared in multiple US states.
Adams L. Sibley, Madigan L. Bedard, Samuel Tobias, Brooke A. Chidgey, Irina G. Phillips, Alice Bell, Nabarun Dasgupta   +6 more
wiley   +1 more source

Effect of acute and repeated administration of paracetamol on opioidergic and serotonergic systems in rats. [PDF]

, 2007
Objective and design: We investigated the antinociceptiveeffect of paracetamol or morphine after repeatedadministration and the changes in the characteristics of centralμ-, κ- and 5-HT2 receptors.Treatment: Male rats were injected twice a day for ...
PINI, Luigi Alberto, RUGGIERI, Valentina, SANDRINI, Maurizio, VITALE, Giovanni   +3 more
core   +1 more source

Urgent Need for Pairing Training and Education With Fentanyl Test Strip Distribution

Drug and Alcohol Review, EarlyView.
ABSTRACT Introduction Fentanyl test strips (FTS) are increasingly recommended for non‐heroin drugs to detect potential fentanyl adulteration. The aim of this study was to better understand how people are using FTS. Methods In simulation exercises between September and October 2023, 40 people who used drugs participated in a mock use of FTS on a ...
Megan K. Reed, Tracy Esteves Camacho, Kristin L. Rising, Rose Laurano, Danielle Albaciete, Stephen E. Lankenau   +5 more
wiley   +1 more source

Secondary metabolites isolated from Pinus roxburghii and interpretation of their cannabinoid and opioid binding properties by virtual screening and in vitro studies

Saudi Pharmaceutical Journal, 2018
Pinus roxburghii is highly popular as a potent analgesic and anti-inflammatory agent; however its exact mechanism of action was not fully elucidated. We aimed to interpret the analgesic and anti-inflammatory activity of the total ethanol extract of Pinus
Rola M. Labib, Radhakrishnan Srivedavyasasri, Fadia S. Youssef, Samir A. Ross   +3 more
doaj   +1 more source

Biased Opioid Ligands

Molecules, 2020
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi, Balazs R. Varga, Susruta Majumdar   +2 more
doaj   +1 more source

Ingestion of amniotic fluid enhances the facilitative effect of VTA morphine on the onset of maternal behavior in virgin rats [PDF]

, 2009
Previous research has shown that injection of morphine into the ventral tegmental area(VTA) facilitates the onset of maternal behavior in virgin female rats, and injection of the opioid antagonist naltrexone into the VTA disrupts the onset of maternal ...
Daigler, Lindsey B., Hoey, Robert F., Kristal, Dr. Mark B., Neumann, Anne, Thompson, Dr. Alexis C.   +4 more
core  

Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers [PDF]

, 2014
The chemokine prokineticin 2 (PK2) activates its cognate G protein-coupled receptor (GPCR) PKR2 to elicit various downstream signaling pathways involved in diverse biological processes.
Caltabiano, G, Hanyaloglu, AC, Miele, R, Sposini, S   +3 more
core   +1 more source

Electroacupuncture as a treatment for suspected trigeminal nerve‐mediated head‐shaking in 42 horses

Equine Veterinary Education, EarlyView.
Summary Background Electroacupuncture (EA) has been used successfully as a treatment for trigeminal nerve‐mediated head‐shaking (TMHS) in a small case series, but results from a larger number of cases are lacking. Objectives To retrospectively investigate the effectiveness of EA as a treatment for horses with TMHS.
B. Dunkel, G. L. Hildon, K. M. Coumbe, E. Busuttil, D. von Schweinitz, S. Devereux   +5 more
wiley   +1 more source

Oral Status in Relation to Demographic, Socioeconomic, Medical and Psychosocial Risk Factors Among Outpatients in Addiction Treatment Centers, Stockholm, Sweden

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To investigate oral status in relation to demographic, socioeconomic, medical and psychosocial risk factors among outpatients receiving treatment for Substance Use Disorder (SUD). Methods This cross‐sectional study included 91 outpatients from Stockholm, Sweden. Oral status was assessed using the Decayed, Missing, Filled Teeth (DMFT)
Sonja Rafat, Stefan Borg, Gunnar Edman, Anders Hammarberg, Patricia De Palma   +4 more
wiley   +1 more source