Results 111 to 120 of about 62,533 (281)

Methadone ameliorates multiple-low-dose streptozotocin-induced type 1 diabetes in mice [PDF]

Type 1 diabetes is an autoimmune disease characterized by inflammation of pancreatic islets and destruction of β cells by the immune system. Opioids have been shown to modulate a number of immune functions, including T helper 1 (Th1) and T helper 2 ...
امیرشاهرخی, کیوان, حاجتی, جمشيد, دهپور, احمدرضا, ستوده, مسعود, قاضی خوانساری, محمود   +4 more
core   +1 more source

Opioids, sex and gender [PDF]

, 2011
JUSTIFICATIVA E OBJETIVOS: Sexo é um fator importante na modulação da experiência dolorosa. Evidências significativas têm demonstrado que a experiência à dor difere entre homens e mulheres, bem como na resposta à ativação do sistema opioide e seus ...
ASHMAWI, Hazem A., OLIVEIRA JUNIOR, José Oswaldo de, PALMEIRA, Cláudia C. de A., POSSO, Irimar de Paula   +3 more
core   +1 more source

Association Between Herpes Zoster and Risk of Incident Fragility Fractures in US Veterans: A Matched Cohort Study

Journal of the American Geriatrics Society, EarlyView.
Association between herpes zoster and risk of incident fragility fractures in US veterans: a matched cohort study. ABSTRACT Background Herpes zoster (HZ) and fragility fractures typically affect older adults and present major burdens to healthcare systems.
Calif A. A. Yousuf, Julie A. Womack, Roger J. Bedimo, Christopher T. Rentsch, Charlotte Warren‐Gash   +4 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Kappa Opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons [PDF]

, 2015
The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular and neural circuit mechanisms are not understood.
Bruchas, Michael R, Chavkin, Charles, Ehrich, Jonathan M, Kieffer, Brigitte L, Knakal, Cerise R, Kuhar, Jamie R, Messinger, Daniel I, Phillips, Paul E M, Schatteuer, Selena S, Zweifel, Larry S   +9 more
core   +3 more sources

The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a chronic metabolic disease characterized by disturbances in energy homeostasis, leading to excessive fat accumulation. The pathogenesis of the disease is shaped by a complex interplay of genetic, epigenetic, biological, psychological, and environmental factors.
Gašper Tonin, Stjepan Eržen, Zala Mlinarič, Dubravka Jurišić Eržen, Simon Horvat, Tanja Kunej, Jasna Klen   +6 more
wiley   +1 more source

Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides [PDF]

, 2015
Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ...
Beaudry, Francis, Saidi, Mouna
core   +1 more source

A Review of Antioxidant Activity, Anti‐Inflammatory Properties, Apoptosis‐Regulatory Effects, and Immune System Modulation of Juglans regia L. (Walnut)

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
J. regia L. represents a valuable natural source of antioxidants, anti‐inflammatory agents, apoptosis‐regulatory agents, and immunomodulators. The walnut‐rich phytochemical profile contributes to its therapeutic potential in combating oxidative stress and inflammation, regulating apoptosis and immune responses.
Mahboobeh Ghasemzadeh Rahbardar, Mostafa Rashki, Mohammad Hossein Boskabady   +2 more
wiley   +1 more source

A receptor-based analysis of local ecosystems in the human brain. [PDF]

, 2017
BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core   +1 more source

Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction‐related phenomena. Addiction‐related memories, like strong aversive memories, are often highly resistant to extinction and can continue to drive relapse ...
M. Cutler, A. Thati, S. L. Grella
wiley   +1 more source