Results 111 to 120 of about 18,176 (269)
Biochemistry of opioid (morphine) receptors : binding, structure and molecular modelling [PDF]
, 2015 Morphine is the most widely used compound among narcotic analgesics and remains the gold standard when the effects of other analgetic drugs are compared.
Benyhe, Sándor +2 more
core
Molecules, 2020 Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi +2 more
doaj +1 more source
HIV Medicine, EarlyView.Abstract Introduction HIV viral load (VL) is a key predictor of long‐term health for women living with HIV. Here, we investigate how HIV VL self‐reported by women living with HIV enrolled in the British Columbia CARMA‐CHIWOS Collaboration Study relates to clinically measured HIV VL.
Tetiana Povshedna +10 more
wiley +1 more source
A Novel Gβγ-Subunit Inhibitor Selectively Modulates μ-Opioid- Dependent Antinociception and Attenuates Acute Morphine-Induced Antinociceptive Tolerance and Dependence [PDF]
, 2008 The Gβγ subunit has been implicated in many downstream signaling events associated with opioids. We previously demonstrated that a small molecule inhibitor of Gβγ-subunit-dependent phospholipase (PLC) activation potentiated morphine-induced analgesia ...
Bidlack, Jean M +2 more
core +2 more sources
Dynamics of cooperativity in chemical sensing among cell-surface receptors [PDF]
, 2011 Cooperative interactions among sensory receptors provide a general mechanism to increase the sensitivity of signal transduction. In particular, bacterial chemotaxis receptors interact cooperatively to produce an ultrasensitive response to chemoeffector concentrations.
arxiv +1 more source
International Journal of Dental Hygiene, EarlyView.ABSTRACT Objective To investigate oral status in relation to demographic, socioeconomic, medical and psychosocial risk factors among outpatients receiving treatment for Substance Use Disorder (SUD). Methods This cross‐sectional study included 91 outpatients from Stockholm, Sweden. Oral status was assessed using the Decayed, Missing, Filled Teeth (DMFT)
Sonja Rafat +4 more
wiley +1 more source
In vivo trafficking of endogenous opioid receptors [PDF]
, 2008 Studies on trafficking of endogenous opioid receptors in vivo are subject of the present review. In many of the in vivo studies, the use of semi-quantitative immuno-electron microscopy is the approach of choice.
Liu-Chen, Lee-Yuan +2 more
core +2 more sources
Receptor arrays optimized for natural odor statistics [PDF]
, 2016 Natural odors typically consist of many molecules at different concentrations. It is unclear how the numerous odorant molecules and their possible mixtures are discriminated by relatively few olfactory receptors. Using an information-theoretic model, we show that a receptor array is optimal for this task if it achieves two possibly conflicting goals ...
arxiv +1 more source
Multivalent "Attacker & Guard" Strategy for Targeting Surfaces with Low Receptor Density [PDF]
, 2018 Multivalent particles, i.e. microscopic constructs having multiple ligands, can be used to target surfaces selectively depending on their receptor density. Typically, there is a sharp onset of multivalent binding as the receptor density exceeds a given threshold.
arxiv +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT A randomized, blinded, placebo‐controlled crossover study was performed with eight professional working dogs to evaluate the pharmacokinetics and pharmacodynamics of three opioid reversal agents. Following sedation with 1 mg kg−1 methadone HCl IV, dogs were randomly assigned to receive naloxone, naltrexone, or nalmefene at 0.1 mg kg−1 IM, or ...
Travis Mills +8 more
wiley +1 more source