Results 11 to 20 of about 4,400 (190)

A practical flow synthesis of 1,2,3-triazoles. [PDF]

RSC Adv, 2022
Copper-on-charcoal is an excellent heterogeneous catalyst for the alkyne–azide cycloaddition reaction performed under continuous flow conditions. 2-Ynoic acids undergo decarboxylation/cycloaddition cascade giving triazoles bearing small alkyl chains.
Drelinkiewicz D, Whitby RJ.
europepmc   +5 more sources

4-Sulfanyl-1,2,3-triazole as a Powerful Ligand in CuAAC to Synthesize 1,4-Substituted 1,2,3-Triazoles Under Solvent-Free and Low Catalyst Loading [PDF]

Molecules
4-Sulfanyl-1,2,3-triazole (L1) accelerated the solvent-free CuAAC efficiently with low catalyst loading (0.1 mol% for common azides and 1 mol% for sulfonyl azides). L1 exhibited higher catalytic activity compared to 1,4-substituted 1,2,3-triazole without
Jie Shen, Jinwei Li, Shitang Xu, Ting Wang, Zhiling Zou, Hui Li, Lifen Peng, Zilong Tang, Xinhua Xu   +8 more
doaj   +2 more sources

1,2,3-Triazoles as Biomimetics in Peptide Science. [PDF]

Molecules, 2021
Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptides is of great importance for the development of new ...
Agouram N, El Hadrami EM, Bentama A.
europepmc   +5 more sources

Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [PDF]

Chemistry - an Asian Journal, 2011
AbstractThe copper(I)‐catalyzed 1,2,3‐triazole‐forming reaction between azides and terminal alkynes has become the gold standard of ‘click chemistry’ due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial ...
Sandip G, Agalave, Suleman R, Maujan, Vandana S, Pore   +2 more
exaly   +3 more sources

Copper-Catalyzed Synthesis of 4-CF₃-1,2,3-Triazoles: An Efficient and Facile Approach via Click Reaction [PDF]

Molecules
Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored a click reaction approach for regioselective synthesis of 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU ...
Tinghong Tang, Cuiting Chen, Xin Fu, Huilan Xu, Luyong Wu, Wenhao Chen   +5 more
doaj   +2 more sources

4,5-Bis(arylethynyl)-1,2,3-triazoles—A New Class of Fluorescent Labels: Synthesis and Applications [PDF]

Molecules, 2022
Cu-catalyzed 1,3-dipolar cycloaddition of ethyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Sonogashira cross-coupling were used to synthesize a large series of new triazole-based push–pull chromophores: 4,5-bis(arylethynyl)-1H-1,2,3-triazoles ...
Anastasia I. Govdi, Polina V. Tokareva, Andrey M. Rumyantsev, Maxim S. Panov, Johannes Stellmacher, Ulrike Alexiev, Natalia A. Danilkina, Irina A. Balova   +7 more
doaj   +2 more sources

Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles [PDF]

Nature Communications
Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic ...
Ling-Feng Jiang, Shao-Hua Wu, Yu-Xuan Jiang, Hong-Xiang Ma, Jia-Jun He, Yang-Bo Bi, De-Yi Kong, Yi-Fei Cheng, Xuan Cheng, Qing-Hai Deng   +9 more
doaj   +2 more sources

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics

CHIMIA, 2013
1,2,3-Triazoles represent a class of heterocycles with interesting properties for application in peptide sciences since they closely resemble amide bonds while being stable to enzymatic degradation.
Ibai E. Valverde, Thomas L. Mindt
doaj   +5 more sources

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Overview of 1,5-Selective Click Reaction of Azides with Alkynes or Their Synthetic Equivalents

Molecules, 2023
Nowadays, the click reaction of azides with alkynes has evolved rapidly and become one of the most efficient methods to synthesize 1,2,3-triazoles, which are an important class of N-containing heterocycles.
Yaqi Zhao, Zhengqi Chai, Qingrui Zeng, Wen-Xiong Zhang   +3 more
doaj   +1 more source