Results 11 to 20 of about 43,142 (242)
A practical flow synthesis of 1,2,3-triazoles. [PDF]
RSC Adv, 2022 Copper-on-charcoal is an excellent heterogeneous catalyst for the alkyne–azide cycloaddition reaction performed under continuous flow conditions. 2-Ynoic acids undergo decarboxylation/cycloaddition cascade giving triazoles bearing small alkyl chains.
Drelinkiewicz D, Whitby RJ.
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“Click” Synthesis of Nonsymmetrical Bis(1,2,3-triazoles)
Organic Letters, 2010 Unsymmetrically 1,1'-disubstituted 4,4'-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole intermediates 5: (a) the stepwise Swern oxidation/Ohira-Bestman alkynylation of readily ...
Aizpurua, Jesús M. +5 more
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Transformations of 1-(Oxiranylmethyl)-1,2,3-triazoles into 2-(Oxiranylmethyl)-1,2,3-triazoles and Alkanenitriles [PDF]
Synlett, 2012 New reactions for the transformation of 1-(oxiranylmethyl)-1,2,3-triazoles into 2-(oxiranylmethyl)-1,2,3-triazoles or alkanenitriles were established. Successive treatment of the substrate with triflic acid and t-BuOH afforded 4,6-dihydro-5-hydroxy-1,3a,6a-triazapentalene derivative.
Osawa, Ayumi +3 more
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1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics
CHIMIA, 2013 1,2,3-Triazoles represent a class of heterocycles with interesting properties for application in peptide sciences since they closely resemble amide bonds while being stable to enzymatic degradation.
Ibai E. Valverde, Thomas L. Mindt
doaj +5 more sources
1,2,3‐Triazoles in Peptidomimetic Chemistry
European Journal of Organic Chemistry, 2011 AbstractThe ability to synthesise small peptidomimetics that mimic the secondary structure of proteins is an ever expanding area of research directed at sourcing new medicinal agents and biological probes. A significant current challenge is to mimic protein epitopes under physiological conditions using small peptidomimetics that are easy to prepare ...
Pedersen, D., Abell, A.
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1,2,3-TRIAZOLES AS POTENT INSECTICIDES
A class of heterocyclic compounds known as 1,2,3-triazoles has a five-membered cycle with two carbons and three nitrogens. 1,2,3-triazoles have attracted a lot of attention in both organic and medicinal chemistry due to their numerous pharmacological and biological characteristics as well as their straightforward synthesis via a click reaction ...
null Dr Sarasija. M +1 more
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1,2,3-Triazoles as Biomimetics in Peptide Science [PDF]
Molecules, 2021 Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptides is of great importance for the development of new ...
Naima Agouram +2 more
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Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
Molecules, 2022 Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or ...
Gavin R. Hoffman, Allen M. Schoffstall
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N-Acyl-1,2,3-triazoles - key intermediates in denitrogenative transformations [PDF]
, 2023 Direct N-acylation of 1,2,3-NH-triazoles aimed at obtaining elusive N-acyl-1,2,3-triazoles was investigated. A preference for the formation of thermodynamically favoured N2 isomers was established and an influence of the hard/soft character of the ...
Vladimir, Motornov +3 more
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Synthesis of Deuterated 1,2,3-Triazoles [PDF]
The Journal of Organic Chemistry, 2012 The copper-catalyzed azide-alkyne cycloaddition (CuAAC) is a highly effective method for the selective incorporation of deuterium atom into the C-5 position of the 1,2,3-triazole structure. Reactions of alkynes and azides can be conveniently carried out in a biphasic medium of CH(2)Cl(2)/D(2)O, using the CuSO(4)/Na ascorbate system. The mildness of the
Hari K, Akula, Mahesh K, Lakshman
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