Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates [PDF]
, 2014 The synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles was achieved under photochemical conditions. This simple and mild one-step reaction provides regiospecific access to 2,4,5-substituted 1,2,3-triazoles via a nitrile imine ...
Harris, Robert +2 more
core +1 more source
Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]
The Ukrainian Biochemical Journal, 2020 Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo +3 more
doaj +1 more source
Triazole-Directed Pd-Catalyzed C(sp2)–H Oxygenation of Arenes and Alkenes [PDF]
, 2016 Selective Pd-catalyzed C(sp2)–H oxygenation of 4-substituted 1,2,3-triazoles is described. Unlike previous metal-catalyzed C–H functionalization events, which preferentially occur at the activated heterocyclic C–H bond, the regioselective oxygenation of ...
Aizpurua Iparraguirre, Jesús María +2 more
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Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]
Exploration of Drug ScienceAim: The development of selective and potent antitumor agents remains a significant challenge. This study aimed to synthesize and evaluate biaryl hydroxy-1,2,3-triazoles and 9H-fluorene-1,2,3-triazole hybrids, inspired by previously identified bioactive ...
David Chafi Zeitune +6 more
doaj +1 more source
The gas phase cyclization of deprotonated N-aryl-2-cyano-2-diazoacetamides [PDF]
, 2005 The document attached has been archived with permission from the publisher.1-Aryl-4-cyano-5-hydroxy-1,2,3-triazoles can be obtained in solution by base-catalysed cyclization of N-aryl-2-cyano-2-diazoacetamides.
Bilusich, D. +6 more
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Morpholine-mediated defluorinative cycloaddition of gem-difluoroalkenes and organic azides
Beilstein Journal of Organic Chemistry, 2023 Here, we report the first transition-metal-free defluorinative cycloaddition of gem-difluoroalkenes with organic azides in morpholine as a solvent to construct fully decorated morpholine-substituted 1,2,3-triazoles.
Tzu-Yu Huang +4 more
doaj +1 more source
Enantioselective synthesis of (+)-petromyroxol, enabled by rhodium-catalyzed denitrogenation and rearrangement of a 1-sulfonyl-1,2,3-triazole [PDF]
, 2015 Petromyroxol is a non-racemic mixture of enantiomeric oxylipids isolated from water conditioned with larval sea lamprey. The (+)-antipode exhibits interesting biological properties but only 1 mg was isolated from >100000 L of water.
Boyer, Alistair
core +2 more sources
Selective C(sp2)−H Halogenation of "click" 4-Aryl-1,2,3-triazoles [PDF]
, 2017 Selective bromination reactions of “click compounds” are described. Electron-neutral and electron-deficient arenes selectively undergo unprecedented Pd-catalyzed C–H ortho-halogenations assisted by simple triazoles as modular directing groups, whereas ...
Correa Navarro, Arkaitz +2 more
core +3 more sources
Pseudo-Four Component Synthesis of Mono- and Di-Benzylated-1,2,3-Triazoles Derived from Aniline
Molecules, 2013 The pseudo-four component click synthesis of dibenzylated 1,2,3-triazoles derived from aniline is reported. The cycloaddition of sodium azide to N-(prop-2-ynyl)-benzenamine (I) in the presence of equimolar amounts of p-substituted benzyl derivatives ...
Daniel Mendoza-Espinosa +4 more
doaj +1 more source
Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition [PDF]
, 2011 A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the ...
Engels, Joachim W. +2 more
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