Results 31 to 40 of about 43,142 (242)
Morpholine-mediated defluorinative cycloaddition of gem-difluoroalkenes and organic azides
Beilstein Journal of Organic Chemistry, 2023 Here, we report the first transition-metal-free defluorinative cycloaddition of gem-difluoroalkenes with organic azides in morpholine as a solvent to construct fully decorated morpholine-substituted 1,2,3-triazoles.
Tzu-Yu Huang +4 more
doaj +1 more source
Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]
The Ukrainian Biochemical Journal, 2020 Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo +3 more
doaj +1 more source
Pseudo-Four Component Synthesis of Mono- and Di-Benzylated-1,2,3-Triazoles Derived from Aniline
Molecules, 2013 The pseudo-four component click synthesis of dibenzylated 1,2,3-triazoles derived from aniline is reported. The cycloaddition of sodium azide to N-(prop-2-ynyl)-benzenamine (I) in the presence of equimolar amounts of p-substituted benzyl derivatives ...
Daniel Mendoza-Espinosa +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang +6 more
wiley +2 more sources
4,5-Bis(arylethynyl)-1,2,3-triazoles—A New Class of Fluorescent Labels: Synthesis and Applications
Molecules, 2022 Cu-catalyzed 1,3-dipolar cycloaddition of ethyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Sonogashira cross-coupling were used to synthesize a large series of new triazole-based push–pull chromophores: 4,5-bis(arylethynyl)-1H-1,2,3-triazoles ...
Anastasia I. Govdi +7 more
doaj +1 more source
Coordinatively unsaturated ruthenium complexes as efficient alkyne-azide cycloaddition catalysts [PDF]
, 2012 The performance of 16-electron ruthenium complexes with the general formula Cp*Ru(L)X (in which L = phosphine or N-heterocyclic carbene ligand; X = Cl or OCH2CF3) was explored in azide−alkyne cycloaddition reactions that afford the 1,2,3- triazole ...
Slawin, Alexandra MZ +15 more
core +1 more source
Three-Component Reactions of CF3 Carbonyls, NaN3, and Amines for the Synthesis of NH-1,2,3-Triazoles
, 2021 The development of methods for the assembly of 1,2,3-triazoles is an important topic due to the broad applications of this motif in various scientific fields.
Ge Gao (5909) +9 more
core +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [PDF]
Chemistry – An Asian Journal, 2011 AbstractThe copper(I)‐catalyzed 1,2,3‐triazole‐forming reaction between azides and terminal alkynes has become the gold standard of ‘click chemistry’ due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial ...
Sandip G, Agalave +2 more
openaire +2 more sources
, 2022 The straightforward synthesis of copper(I) salicylate from salicylic acid and copper(I) oxide is described for the first time and its identity confirmed by XPS and XRDP techniques.
Uvaldo Hernández-Balderas (12697926) +6 more
core +1 more source