Results 101 to 110 of about 89,598 (163)

Synthesis and Anti-Inflammatory Evaluation of 3-Methylthio-1,2,4-Triazines, 3-Alkoxy-1,2,4-Triazines, and 3-Aryloxy-1,2,4-Triazines

Journal of Pharmaceutical Sciences, 1980
To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice.
W P, Heilman, R D, Heilman, J A, Scozzie, R J, Wayner, J M, Gullo, Z S, Ariyan   +5 more
openaire   +2 more sources

Synthesis of 1,2,4-Triazines; XIII. Regioselective Synthesis of Trialkyl-1,2,4-triazines

HETEROCYCLES, 1992
Trialkyl-1,2,4-triazines (3) were prepared by heating α-oxoacylhydrazones (4) or N,N-dimethylaminomethylene hydrazones (19) with ammonium acetate at 100°C.
Hans Neunhoeffer, Tadashi Ohsumi
openaire   +1 more source

Uses of cyclohexane-1,3-dione for the synthesis of 1,2,4-triazine derivatives as anti-proliferative agents and tyrosine kinases inhibitors.

Bioorganic chemistry (Print), 2020
Tetrahydrobenzo[b]thiophene derivatives were well known to be biologically active compounds and many of them occupy a wide range as anticancer agent drugs.
N. Y. Megally Abdo, Rafat Milad Mohareb, Peter A. Halim   +2 more
semanticscholar   +1 more source

Chemistry of 1,2,4‐triazines, XV. First metalation of 1,2,4‐triazine derivatives

Liebigs Annalen der Chemie, 1993
Abstract5‐Methoxy‐1,2,4‐triazines 2 were lithiated with lithium 2,2,6,6‐tetramethylpiperidide and the formed 6‐lithio‐5‐methoxy‐1,2,4‐triazines 4 trapped with aldehydes or iodine.
Nelly Plé, Alain Turck, Guy Quéguiner, Bernd Glassl, Hans Neunhoeffer   +4 more
openaire   +1 more source

The Cytotoxic Effect on HepG2 Cell Line and In Vitro, In Silico Evaluation of 1,2,4‐Triazine Compounds as Inhibitors of Acetylcholinesterase and Glutathione S‐Transferase

Journal of biochemical and molecular toxicology
The inhibitory effects of several 1,2,4‐triazine compounds (Tr‐1, Tr‐2, Tr‐3) on acetylcholinesterase (AChE) and glutathione S‐transferase (GST) enzymes were explored. IC50 values for 1,2,4‐triazine compounds were determined, ranging from 2.45 to 9.91 µM
F. Türkan, A. Çetin, Semanur Kalkan, E. Oğuz   +3 more
semanticscholar   +1 more source

Multi-target inhibitors against Alzheimer disease derived from 3-hydrazinyl 1,2,4-triazine scaffold containing pendant phenoxy methyl-1,2,3-triazole: Design, synthesis and biological evaluation.

Bioorganic chemistry (Print), 2019
Alzheimer's disease (AD) is a complex neurological disorder with diverse underlying pathological processes. Several lines of evidence suggest that BACE1 is a key enzyme in the pathogenesis of AD and its inhibition is of particular importance in AD ...
Mahnaz Yazdani, Najmeh Edraki, R. Badri, M. Khoshneviszadeh, Aida Iraji, O. Firuzi   +5 more
semanticscholar   +1 more source

1,2,4-Triazine

2001
[290-38-0] C3H3N3 (MW 81.09) InChI = 1S/C3H3N3/c1-2-5-6-3-4-1/h1-3H InChIKey = FYADHXFMURLYQI-UHFFFAOYSA-N (electron-deficient heteroaromatic azadiene capable of participation in inverse electron demand Diels–Alder reactions with electron-rich dienophiles1) Alternate Names: as-triazine; α-triazine; isotriazine ...
Dale L. Boger, Minsheng Zhang
openaire   +1 more source

Visible-Light-Induced C-H Alkylation of 1,2,4-Triazine-3,5(2H,4H)-diones via Infrequent 1,2-Hydrogen-Atom Transfer.

Journal of Organic Chemistry
1,2,4-Triazine-3,5(2H,4H)-diones are widely present in various drug molecules and bioactive molecules. A visible-light-driven C-H alkylation of 1,2,4-triazine-3,5(2H,4H)-diones via 1,2-hydrogen-atom transfer (1,2-HAT) of amide radicals is first reported,
Mi Wang, Yangyang Wang, Jie Wang, Yafei Zhu, Penghua Zhang, Cuimei Zhang, Jian Chen, Li Guo, Guanghui Lv, Yong Wu   +9 more
semanticscholar   +1 more source

Condensed 1,2,4‐Triazines, III

Archiv der Pharmazie, 1980
AbstractAlkylation of 3‐mercaptophenanthreno[9,10‐e]‐1,2,4‐triazine (1b) yielded the S‐alkyl derivatives 2 a‐d. Amination of 1a afforded the 3‐amino derivatives 3a‐h. Reaction of 1a with hydrazine hydrate gave 3‐hydrazinophenanthreno[9,10‐e]‐1,2,4‐triazine (4) which underwent cyclisation with nitrous, formic or acetic acids giving the phenanthreno[9,10‐
Vishnu Ji Ram, Hrishi Kesh Pandey
openaire   +1 more source

Design and Synthesis, Antimicrobial Activities of 1,2,4-Triazine Derivatives as Representation of a New Hetrocyclic System

Polycyclic aromatic compounds (Print), 2020
Reaction of pyridine-2-(1H)-one derivatives (diamines) and 1,2-dicarbonyl compounds in the adjacency of acetic acid, a solvent, inexpensive and green catalyst, at 50 °C produced new 1,2,4-triazine derivatives in high yields, and reactions were completed ...
Maryam Shokoohian, N. Hazeri, M. Maghsoodlou, M. Lashkari   +3 more
semanticscholar   +1 more source