Results 31 to 40 of about 89,598 (163)

Novel chalcone derivatives containing a 1,2,4-triazine moiety: design, synthesis, antibacterial and antiviral activities

RSC Advances, 2019
A series of novel chalcone derivatives containing the 1,2,4-triazine moiety were synthesized and their structures were confirmed by 1H NMR, 13C NMR and elemental analyses.
Xu Tang, Shijun Su, Meihang Chen, Jun He, Rongjiao Xia, Tao Guo, Ying Chen, Cheng Zhang, Jun Wang, Wei Xue   +9 more
semanticscholar   +1 more source

Synthesis and examination of 1,2,4‐triazine‐sulfonamide hybrids as potential inhibitory drugs: Inhibition effects on AChE and GST enzymes in silico and in vitro conditions

Archiv der Pharmazie
The crucial functions of acetylcholinesterase (AChE) in neurotransmission and glutathione S‐transferase (GST) in detoxification and cellular protection underscore their pivotal roles as key enzymes, essential for maintaining the integrity of neurological
Przemysław Rozbicki, E. Oğuz, Ewa Wolińska, F. Türkan, A. Çetin, D. Branowska   +5 more
semanticscholar   +1 more source

Fast and Efficient Synthesis of Racemic Baloxavir Catalyzed by Strong Solid Acid under Microwave Conditions

Crystals, 2022
The compound (±)-12aR-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione is the intermediate of baloxavir marboxil.
Yiyun Wang, Xiaofang Lv, Zihui Meng, Zhibin Xu, Zhonghui Zheng, Jiarong Li, Min Xue   +6 more
doaj   +1 more source

5,6-Dimethyl-1,2,4-triazin-3-amine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the crystal structure of the title compound, C(5)H(8)N(4), adjacent mol-ecules are connected through N-H⋯N hydrogen bonds, resulting in a zigzag chain along [100]. The amino groups and heterocyclic N atoms are involved in further N-H⋯N hydrogen bonds, forming R(2) (2)(8) motifs.
Man-Hua Wu, Qi-Ming Qiu, Sen Gao, Qiong-Hua Jin, Cun-Lin Zhang   +4 more
openaire   +3 more sources

2-(5,6-Diphenyl-1,2,4-triazin-3-yl)aniline

Acta Crystallographica Section E, 2012
The title compound, C21H16N4, obtained under standard Suzuki cross-coupling conditions, is a model compound in the synthesis and biological activity evaluation of new aza-analogues of sildenafil containing a pyrazolo[4,3-e][1,2,4]triazine system.
Mariusz Mojzych, Zbigniew Karczmarzyk, Andrzej Fruziński   +2 more
doaj   +1 more source

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

Journal of Medicinal Chemistry, 2012
Potent, ligand efficient, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structure based drug design approaches as antagonists of the adenosine A2A receptor.
M. Congreve, S. P. Andrews, A. S. Doré, K. Hollenstein, E. Hurrell, C. Langmead, J. Mason, I. Ng, B. Tehan, A. Zhukov, M. Weir, F. Marshall   +11 more
semanticscholar   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Structural Design of MOF‐Based and MOF‐Derived Composites for Oxygen Evolution Electrocatalysis: Materials Innovation for Energy and Environmental Sustainability

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This review provides an overview of recent developments in metal organic framework (MOF)‐based and MOF‐derived composites for efficient oxygen evolution reaction. This review also emphasizes the structural design of electrocatalyst, active site optimization, and emerging prospects of their use in practical electrolyzer systems.
Bhagyashri B. Kamble, Aditi De, Seung Joo Jang, Arun Karmkar, Venkatachalam Vinothkumar, Niyaz Mujawar, Subrata Kundu, Tae Hyun Kim   +7 more
wiley   +1 more source

Synthesis of Some New Barbituric and Thiobarbituric Acids Bearing 1,2,4-Triazine Moiety and Their Related Systems as Herbicidal Agents

Journal of Chemistry, 2019
In search for highly bioactive barbituric and thiobarbituric acid derivatives, some new barbituric and thiobarbituric acids bearing 1,2,4-triazine moiety and their related systems (5–13) have been obtained from the addition of isocyanate and ...
Abeer N. Al-Romaizan
doaj   +1 more source

Heteropolyacides as green and reusable catalysts for the synthesis of [3,4-b][1,3,4] thiadiazines

Bulletin of the Chemical Society of Ethiopia, 2014
Synthesis of [3,4-b][1,3,4]thiadiazines from the condensation of 4-amino-6-methyl-3-thioxo-1,2,4-triazine-5(2H)-one (AMTTO) or 4-amino-1,4-dihydro-5-methyle-1,2,4-triazole-5-thione (AMTT) with phenacyl bromide in the presence of a catalytic amount of ...
F. Hakimi, A. Hassanabadi, M. Tabatabaee, M. M. Heravi   +3 more
doaj   +1 more source